Pathologic and Clinical Characteristics of Elderly Patients With Breast Cancer: A Retrospective Analysis of a Multicenter Study (Anatolian Society of Medical Oncology)

There is very little information about breast cancer characteristics, treatment choices, and survival among elderly patients. The purpose of this multicenter retrospective study was to examine the clinical, pathologic, and biologic characteristics of 620 breast cancer patients age 70 years or older. Between June 1991 and May 2012, 620 patients with breast cancer, recruited from 16 institutions, were enrolled in the retrospective study. Patients had smaller tumors at diagnosis; only 15% of patients had tumors larger than 5 cm. The number of patients who had no axillary lymph node involvement was 203 (32.7%). Ninety-three patients (15.0%) had metastatic disease at diagnosis. Patients were characterized by a higher fraction of pure lobular carcinomas (75.3%). The tumors of the elderly patients were also more frequently estrogen receptor (ER) positive (75.2%) and progesterone receptor (PR) positive (67.3%). The local and systemic therapies for breast cancer differed according to age. An association between age and overall survival has not been demonstrated in elderly patients with breast cancer. In conclusion, the biologic behavior of older patients with breast cancer differs from younger patients, and older patients receive different treatments.

Yazar Inal, Ali
Akman, Tulay
Yaman, Sebnem
Ozturk, Selcuk Cemil
Geredeli, Caglayan
Bilici, Mehmet
Inanc, Mevlude
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3071
Tek Biçim Adres 10.9738/INTSURG-D-13-00010
Konu Başlıkları Breast cancer
Elderly patients
Clinical characteristics
Pathologic characteristics
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı INTERNATIONAL SURGERY
Dergi Cilt Bilgisi 99
Dergi Sayısı 1
Sayfalar 2 - 7
Yayın Yılı 2014
Eser Adı
[dc.title]
Pathologic and Clinical Characteristics of Elderly Patients With Breast Cancer: A Retrospective Analysis of a Multicenter Study (Anatolian Society of Medical Oncology)
Yazar
[dc.contributor.author]
Inal, Ali
Yazar
[dc.contributor.author]
Akman, Tulay
Yazar
[dc.contributor.author]
Yaman, Sebnem
Yazar
[dc.contributor.author]
Ozturk, Selcuk Cemil
Yazar
[dc.contributor.author]
Geredeli, Caglayan
Yazar
[dc.contributor.author]
Bilici, Mehmet
Yazar
[dc.contributor.author]
Inanc, Mevlude
Yayın Yılı
[dc.date.issued]
2014
Yayıncı
[dc.publisher]
INT COLLEGE OF SURGEONS
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
There is very little information about breast cancer characteristics, treatment choices, and survival among elderly patients. The purpose of this multicenter retrospective study was to examine the clinical, pathologic, and biologic characteristics of 620 breast cancer patients age 70 years or older. Between June 1991 and May 2012, 620 patients with breast cancer, recruited from 16 institutions, were enrolled in the retrospective study. Patients had smaller tumors at diagnosis; only 15% of patients had tumors larger than 5 cm. The number of patients who had no axillary lymph node involvement was 203 (32.7%). Ninety-three patients (15.0%) had metastatic disease at diagnosis. Patients were characterized by a higher fraction of pure lobular carcinomas (75.3%). The tumors of the elderly patients were also more frequently estrogen receptor (ER) positive (75.2%) and progesterone receptor (PR) positive (67.3%). The local and systemic therapies for breast cancer differed according to age. An association between age and overall survival has not been demonstrated in elderly patients with breast cancer. In conclusion, the biologic behavior of older patients with breast cancer differs from younger patients, and older patients receive different treatments.
Açıklama
[dc.description]
WOS: 000330382700002
Açıklama
[dc.description]
PubMed: 24444261
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Breast cancer
Konu Başlıkları
[dc.subject]
Elderly patients
Konu Başlıkları
[dc.subject]
Clinical characteristics
Konu Başlıkları
[dc.subject]
Pathologic characteristics
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0020-8868
İlk Sayfa Sayısı
[dc.identifier.startpage]
2
Son Sayfa Sayısı
[dc.identifier.endpage]
7
Dergi Adı
[dc.relation.journal]
INTERNATIONAL SURGERY
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
99
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.9738/INTSURG-D-13-00010
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3071
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
13
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
18 Şubat 2024 18:01
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Tıklayınız
patients breast cancer elderly tumors positive diagnosis receptor Patients biologic retrospective characteristics survival fraction characterized higher lobular carcinomas estrogen frequently according progesterone treatments different receive younger differs behavior conclusion demonstrated overall between association metastatic differed
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