Acetaminophen Mitigates Myocardial Injury Induced by Lower Extremity Ischemia-Reperfusion in Rat Model

Objective: The injury-reducing effect of acetaminophen, an effective analgesic and antipyretic on ischemia-reperfusion continues to attract great attention. This study analyzed the protective effect of acetaminophen on myocardial injury induced by ischemia-reperfusion in an experimental animal model from lower extremity ischemia-reperfusion. Methods: Twenty-four Sprague-Dawley female rats were randomized into three groups (n=8) as (i) control group (only laparotomy), (ii) aortic ischemia-reperfusion group (60 min of ischemia and 120 min of reperfusion) and (iii) ischemia-reperfusion + acetaminophen group (15 mg/kg/h intravenous acetaminophen infusion starting 15 minutes before the end of the ischemic period and lasting till the end of the reperfusion period). Sternotomy was performed in all groups at the end of the reperfusion period and the heart was removed for histopathological examination. The removed hearts were histopathologically investigated for myocytolysis, polymorphonuclear leukocyte (PMNL) infiltration, myofibrillar edema and focal hemorrhage. Results: The results of histopathological examination showed that acetaminophen was detected to particularly diminish focal hemorrhage and myofibrillar edema in the ischemia-reperfusion + acetaminophen group (P<0.001, P=0.011), while there were no effects on myocytolysis and PMNL infiltration between the groups (P=1.000, P=0.124). Conclusion: Acetaminophen is considered to have cardioprotective effect in rats, by reducing myocardial injury induced by abdominal aortic ischemia-reperfusion.

Yazar Geldi, Onur
Kubat, Emre
Unal, Celal Selcuk
Canbaz, Suat
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2014
Tek Biçim Adres 10.21470/1678-9741-2017-0218
Konu Başlıkları Aorta, Abdominal
Acetaminophen
Reperfusion Injury
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı BRAZILIAN JOURNAL OF CARDIOVASCULAR SURGERY
Dergi Cilt Bilgisi 33
Dergi Sayısı 3
Sayfalar 258 - 264
Yayın Yılı 2018
Eser Adı
[dc.title]
Acetaminophen Mitigates Myocardial Injury Induced by Lower Extremity Ischemia-Reperfusion in Rat Model
Yazar
[dc.contributor.author]
Geldi, Onur
Yazar
[dc.contributor.author]
Kubat, Emre
Yazar
[dc.contributor.author]
Unal, Celal Selcuk
Yazar
[dc.contributor.author]
Canbaz, Suat
Yayın Yılı
[dc.date.issued]
2018
Yayıncı
[dc.publisher]
SOC BRASIL CIRURGIA CARDIOVASC
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective: The injury-reducing effect of acetaminophen, an effective analgesic and antipyretic on ischemia-reperfusion continues to attract great attention. This study analyzed the protective effect of acetaminophen on myocardial injury induced by ischemia-reperfusion in an experimental animal model from lower extremity ischemia-reperfusion. Methods: Twenty-four Sprague-Dawley female rats were randomized into three groups (n=8) as (i) control group (only laparotomy), (ii) aortic ischemia-reperfusion group (60 min of ischemia and 120 min of reperfusion) and (iii) ischemia-reperfusion + acetaminophen group (15 mg/kg/h intravenous acetaminophen infusion starting 15 minutes before the end of the ischemic period and lasting till the end of the reperfusion period). Sternotomy was performed in all groups at the end of the reperfusion period and the heart was removed for histopathological examination. The removed hearts were histopathologically investigated for myocytolysis, polymorphonuclear leukocyte (PMNL) infiltration, myofibrillar edema and focal hemorrhage. Results: The results of histopathological examination showed that acetaminophen was detected to particularly diminish focal hemorrhage and myofibrillar edema in the ischemia-reperfusion + acetaminophen group (P<0.001, P=0.011), while there were no effects on myocytolysis and PMNL infiltration between the groups (P=1.000, P=0.124). Conclusion: Acetaminophen is considered to have cardioprotective effect in rats, by reducing myocardial injury induced by abdominal aortic ischemia-reperfusion.
Açıklama
[dc.description]
WOS: 000441342700009
Açıklama
[dc.description]
PubMed: 30043918
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Aorta, Abdominal
Konu Başlıkları
[dc.subject]
Acetaminophen
Konu Başlıkları
[dc.subject]
Reperfusion Injury
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0102-7638
ISSN
[dc.identifier.issn]
1678-9741
İlk Sayfa Sayısı
[dc.identifier.startpage]
258
Son Sayfa Sayısı
[dc.identifier.endpage]
264
Dergi Adı
[dc.relation.journal]
BRAZILIAN JOURNAL OF CARDIOVASCULAR SURGERY
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
33
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.21470/1678-9741-2017-0218
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2014
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
10
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
18 Şubat 2024 09:03
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Tıklayınız
ischemia-reperfusion acetaminophen groups effect infiltration aortic myofibrillar myocytolysis myocardial induced examination reperfusion period removed histopathological hemorrhage injury (PMNL) hearts histopathologically leukocyte polymorphonuclear investigated Objective diminish Results between abdominal reducing cardioprotective considered Acetaminophen Conclusion results effects
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