Lipid peroxidation and homocysteine levels in Behcet's disease

Background: The aim of this study was to investigate serum paraoxonase (PON1) activity in relation to homocysteine, malondialdehyde (MDA) and lipid parameters in active and inactive Behcet's disease, (BD). Methods: A total of 46 consecutive BD patients and 25 healthy control subjects were included in the present study. Results: Serum PON1 activity in both active and inactive BD was significantly lower compared with healthy subjects (p < 0.05). When compared to the control group, serum MDA levels were significantly higher in both active and inactive BD (p < 0.05). Serum C-reactive protein (CRP) and homocysteine concentrations were significantly higher in active BD than those in inactive BD and control subjects (p < 0.05). In addition, there was significant negative correlation between serum PON1 and MDA levels (r= -0.697, p < 0.05) and serum PON1 activity was also negatively correlated with homocysteine levels (r= -0.428, p < 0.05) in BD patients. Conclusions: Decreased PON1 could explain the increased lipid peroxidation and oxidative stress observed in BD. Also, according to our results, we suggest that homocysteine may contribute to decreased serum PON1 activity.

Yazar Mungan, A. Gorkem
Can, Murat
Acikgoz, Serefden
Esturk, Emel
Altinyazar, Cevdet
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2881
Tek Biçim Adres 10.1515/CCLM.2006.191
Konu Başlıkları Behcet's disease
homocysteine
lipid peroxidation
paraoxonase
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı CLINICAL CHEMISTRY AND LABORATORY MEDICINE
Dergi Cilt Bilgisi 44
Dergi Sayısı 9
Sayfalar 1115 - 1118
Yayın Yılı 2006
Eser Adı
[dc.title]
Lipid peroxidation and homocysteine levels in Behcet's disease
Yazar
[dc.contributor.author]
Mungan, A. Gorkem
Yazar
[dc.contributor.author]
Can, Murat
Yazar
[dc.contributor.author]
Acikgoz, Serefden
Yazar
[dc.contributor.author]
Esturk, Emel
Yazar
[dc.contributor.author]
Altinyazar, Cevdet
Yayın Yılı
[dc.date.issued]
2006
Yayıncı
[dc.publisher]
WALTER DE GRUYTER & CO
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background: The aim of this study was to investigate serum paraoxonase (PON1) activity in relation to homocysteine, malondialdehyde (MDA) and lipid parameters in active and inactive Behcet's disease, (BD). Methods: A total of 46 consecutive BD patients and 25 healthy control subjects were included in the present study. Results: Serum PON1 activity in both active and inactive BD was significantly lower compared with healthy subjects (p < 0.05). When compared to the control group, serum MDA levels were significantly higher in both active and inactive BD (p < 0.05). Serum C-reactive protein (CRP) and homocysteine concentrations were significantly higher in active BD than those in inactive BD and control subjects (p < 0.05). In addition, there was significant negative correlation between serum PON1 and MDA levels (r= -0.697, p < 0.05) and serum PON1 activity was also negatively correlated with homocysteine levels (r= -0.428, p < 0.05) in BD patients. Conclusions: Decreased PON1 could explain the increased lipid peroxidation and oxidative stress observed in BD. Also, according to our results, we suggest that homocysteine may contribute to decreased serum PON1 activity.
Açıklama
[dc.description]
WOS: 000241193800014
Açıklama
[dc.description]
PubMed: 16958606
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Behcet's disease
Konu Başlıkları
[dc.subject]
homocysteine
Konu Başlıkları
[dc.subject]
lipid peroxidation
Konu Başlıkları
[dc.subject]
paraoxonase
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1434-6621
İlk Sayfa Sayısı
[dc.identifier.startpage]
1115
Son Sayfa Sayısı
[dc.identifier.endpage]
1118
Dergi Adı
[dc.relation.journal]
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
Dergi Sayısı
[dc.identifier.issue]
9
Dergi Cilt Bilgisi
[dc.identifier.volume]
44
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1515/CCLM.2006.191
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2881
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
23
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 10:23
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Tıklayınız
inactive active homocysteine activity significantly control subjects levels higher compared patients healthy addition results significant negative correlation between decreased contribute suggest according Conclusions observed stress oxidative negatively peroxidation correlated increased explain Decreased Background Methods investigate
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