Helicobacter pylori Infection: Protective Against Increased Interdialytic Weight Gain in Asymptomatic Hemodialysis Patients?

Objective: Infection with Helicobacter pylori, which induces persistent and uncontrolled gastric inflammation leading to decreased appetite, might be protective against obesity. There is a close relationship between interdialytic weight gain (IDWG) and nutritional parameters, confirming the role of IDWG as a marker of calorie and protein intake in hemodialysis (HD) patients. Hypothesis of the present study was that infection with H pylori in subjects with uremia might cause inflammation, diminished appetite, anorexia, and decreased IDWG. Design: A cross-sectional study was conducted. Settings: This trial involved HD patients from a state hospital. Methods: Demographic, laboratory, and clinical parameters were collected. All patients were clinically stable and euvolemic and their average IDWG percent was calculated. Malnutrition inflammation score, spKt/V, and normalized protein equivalent of total nitrogen appearance were determined. Patients were asked to rate their appetite status from 1 to 5 on a Likert scale (very good, good, fair, poor, and very poor appetite, respectively). An H pylori infection was detected by the H pylori stool antigen (HpSA) in all the patients. Results: HpSA was positive in 18 (30%) patients. None of the demographic and laboratory parameters differed between patients infected with HpSA and the noninfected patients. Stepwise linear regression analysis of independent factors related with IDWG% revealed that daily urine output (beta = -0.432, P< .0001), serum phosphorus (beta = +0.343, P = .004), and hemoglobin (beta = +0.358, P = .003) were related with IDWG%. Conclusions: Infection with H pylori is not related with IDWG% and nutritional parameters in HD patients. (C) 2011 by the National Kidney Foundation, Inc. All rights reserved.

Yazar Afsar, Baris
Elsurer, Rengin
Huddam, Bulent
Erden, Caner
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2707
Tek Biçim Adres 10.1053/j.jrn.2010.06.025
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı JOURNAL OF RENAL NUTRITION
Dergi Cilt Bilgisi 21
Dergi Sayısı 4
Sayfalar 322 - 328
Yayın Yılı 2011
Eser Adı
[dc.title]
Helicobacter pylori Infection: Protective Against Increased Interdialytic Weight Gain in Asymptomatic Hemodialysis Patients?
Yazar
[dc.contributor.author]
Afsar, Baris
Yazar
[dc.contributor.author]
Elsurer, Rengin
Yazar
[dc.contributor.author]
Huddam, Bulent
Yazar
[dc.contributor.author]
Erden, Caner
Yayın Yılı
[dc.date.issued]
2011
Yayıncı
[dc.publisher]
W B SAUNDERS CO-ELSEVIER INC
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective: Infection with Helicobacter pylori, which induces persistent and uncontrolled gastric inflammation leading to decreased appetite, might be protective against obesity. There is a close relationship between interdialytic weight gain (IDWG) and nutritional parameters, confirming the role of IDWG as a marker of calorie and protein intake in hemodialysis (HD) patients. Hypothesis of the present study was that infection with H pylori in subjects with uremia might cause inflammation, diminished appetite, anorexia, and decreased IDWG. Design: A cross-sectional study was conducted. Settings: This trial involved HD patients from a state hospital. Methods: Demographic, laboratory, and clinical parameters were collected. All patients were clinically stable and euvolemic and their average IDWG percent was calculated. Malnutrition inflammation score, spKt/V, and normalized protein equivalent of total nitrogen appearance were determined. Patients were asked to rate their appetite status from 1 to 5 on a Likert scale (very good, good, fair, poor, and very poor appetite, respectively). An H pylori infection was detected by the H pylori stool antigen (HpSA) in all the patients. Results: HpSA was positive in 18 (30%) patients. None of the demographic and laboratory parameters differed between patients infected with HpSA and the noninfected patients. Stepwise linear regression analysis of independent factors related with IDWG% revealed that daily urine output (beta = -0.432, P< .0001), serum phosphorus (beta = +0.343, P = .004), and hemoglobin (beta = +0.358, P = .003) were related with IDWG%. Conclusions: Infection with H pylori is not related with IDWG% and nutritional parameters in HD patients. (C) 2011 by the National Kidney Foundation, Inc. All rights reserved.
Açıklama
[dc.description]
WOS: 000291719600008
Açıklama
[dc.description]
PubMed: 20850344
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1051-2276
İlk Sayfa Sayısı
[dc.identifier.startpage]
322
Son Sayfa Sayısı
[dc.identifier.endpage]
328
Dergi Adı
[dc.relation.journal]
JOURNAL OF RENAL NUTRITION
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
21
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1053/j.jrn.2010.06.025
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2707
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
16
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
17 Şubat 2024 12:34
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patients pylori parameters appetite inflammation related nutritional protein decreased Infection between infection laboratory positive demographic (HpSA) Results infected antigen detected respectively) Likert differed noninfected reserved rights Foundation Kidney National Conclusions hemoglobin phosphorus Stepwise output revealed
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