Correlation of serum tumor necrosis factor-alpha, interleukin-4 and soluble interleukin-2 receptor levels with radiologic and clinical manifestations in active pulmonary tuberculosis

THE precise clinical manifestations of tuberculosis are likely to result from a complex interaction between the host and the pathogen. We took serum samples from a group of patients with a variety of clinical and radiological stages of pulmonary tuberculosis in order to characterize tumor necrosis factor-alpha (TNF-alpha), interleukin-4 (IL-4) and soluble interleukin-2 receptor (sIL-2R) response. We further evaluated whether the levels of TNF-alpha, IL-4 and soluble IL-2R are related with each other, and also evaluated the levels of TNF-alpha, IL-4 and sIL-2R after anti-tuberculosis therapy and relation with radiologic scores. Forty-three inpatients with active pulmonary tuberculosis and 19 healthy controls participated in the study. Patients were divided into four categories radiologically on chest X-ray ( minimal, moderate-advanced, far-advanced and with miliary infiltration). Concentrations of TNF-alpha (20.9 +/- 10/15.4 +/- 8 pg/ml) and sIL-2R (2569 +/- 842/1444 +/- 514 pg/ml) were statistically different between patients and controls ( p = 0.02 and p = 0.0001, respectively). Before chemotherapy there was a positive correlation between TNF-alpha and sIL-2R (r = 0.34), but there was no correlation between IL-4 and TNF-alpha, and between IL-4 and sIL-2R (r = -0.23 and r = -0.22). The TNF-alpha level was not statistically different in four groups before and after chemotherapy. Results of this study provided some evidence confirming the previously reported role of TNF-alpha, IL-4 and sIL 2R in the control of tuberculosis, but these cytokines were not found related with disease severity.

Yazar Kart, L
Buyukoglan, H
Tekin, IO
Altin, R
Senturk, Z
Gulmez, I
Demir, R
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2316
Tek Biçim Adres 10.1080/0962935031000096926
Konu Başlıkları tuberculosis
radiologic manifestation
cytokine
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı MEDIATORS OF INFLAMMATION
Dergi Cilt Bilgisi 12
Dergi Sayısı 1
Sayfalar 9 - 14
Yayın Yılı 2003
Eser Adı
[dc.title]
Correlation of serum tumor necrosis factor-alpha, interleukin-4 and soluble interleukin-2 receptor levels with radiologic and clinical manifestations in active pulmonary tuberculosis
Yazar
[dc.contributor.author]
Kart, L
Yazar
[dc.contributor.author]
Buyukoglan, H
Yazar
[dc.contributor.author]
Tekin, IO
Yazar
[dc.contributor.author]
Altin, R
Yazar
[dc.contributor.author]
Senturk, Z
Yazar
[dc.contributor.author]
Gulmez, I
Yazar
[dc.contributor.author]
Demir, R
Yayın Yılı
[dc.date.issued]
2003
Yayıncı
[dc.publisher]
HINDAWI LTD
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
THE precise clinical manifestations of tuberculosis are likely to result from a complex interaction between the host and the pathogen. We took serum samples from a group of patients with a variety of clinical and radiological stages of pulmonary tuberculosis in order to characterize tumor necrosis factor-alpha (TNF-alpha), interleukin-4 (IL-4) and soluble interleukin-2 receptor (sIL-2R) response. We further evaluated whether the levels of TNF-alpha, IL-4 and soluble IL-2R are related with each other, and also evaluated the levels of TNF-alpha, IL-4 and sIL-2R after anti-tuberculosis therapy and relation with radiologic scores. Forty-three inpatients with active pulmonary tuberculosis and 19 healthy controls participated in the study. Patients were divided into four categories radiologically on chest X-ray ( minimal, moderate-advanced, far-advanced and with miliary infiltration). Concentrations of TNF-alpha (20.9 +/- 10/15.4 +/- 8 pg/ml) and sIL-2R (2569 +/- 842/1444 +/- 514 pg/ml) were statistically different between patients and controls ( p = 0.02 and p = 0.0001, respectively). Before chemotherapy there was a positive correlation between TNF-alpha and sIL-2R (r = 0.34), but there was no correlation between IL-4 and TNF-alpha, and between IL-4 and sIL-2R (r = -0.23 and r = -0.22). The TNF-alpha level was not statistically different in four groups before and after chemotherapy. Results of this study provided some evidence confirming the previously reported role of TNF-alpha, IL-4 and sIL 2R in the control of tuberculosis, but these cytokines were not found related with disease severity.
Açıklama
[dc.description]
WOS: 000182332700002
Açıklama
[dc.description]
PubMed: 12745543
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
tuberculosis
Konu Başlıkları
[dc.subject]
radiologic manifestation
Konu Başlıkları
[dc.subject]
cytokine
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0962-9351
ISSN
[dc.identifier.issn]
1466-1861
İlk Sayfa Sayısı
[dc.identifier.startpage]
9
Son Sayfa Sayısı
[dc.identifier.endpage]
14
Dergi Adı
[dc.relation.journal]
MEDIATORS OF INFLAMMATION
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
12
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1080/0962935031000096926
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2316
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
11
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 23:22
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Tıklayınız
TNF-alpha between sIL-2R tuberculosis soluble chemotherapy evaluated levels related correlation controls statistically different pulmonary clinical pg/ml) patients respectively) Before 842/1444 positive confirming severity disease cytokines control reported previously evidence provided Results before groups Concentrations Patients
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