THE precise clinical manifestations of tuberculosis are likely to result from a complex interaction between the host and the pathogen. We took serum samples from a group of patients with a variety of clinical and radiological stages of pulmonary tuberculosis in order to characterize tumor necrosis factor-alpha (TNF-alpha), interleukin-4 (IL-4) and soluble interleukin-2 receptor (sIL-2R) response. We further evaluated whether the levels of TNF-alpha, IL-4 and soluble IL-2R are related with each other, and also evaluated the levels of TNF-alpha, IL-4 and sIL-2R after anti-tuberculosis therapy and relation with radiologic scores. Forty-three inpatients with active pulmonary tuberculosis and 19 healthy controls participated in the study. Patients were divided into four categories radiologically on chest X-ray ( minimal, moderate-advanced, far-advanced and with miliary infiltration). Concentrations of TNF-alpha (20.9 +/- 10/15.4 +/- 8 pg/ml) and sIL-2R (2569 +/- 842/1444 +/- 514 pg/ml) were statistically different between patients and controls ( p = 0.02 and p = 0.0001, respectively). Before chemotherapy there was a positive correlation between TNF-alpha and sIL-2R (r = 0.34), but there was no correlation between IL-4 and TNF-alpha, and between IL-4 and sIL-2R (r = -0.23 and r = -0.22). The TNF-alpha level was not statistically different in four groups before and after chemotherapy. Results of this study provided some evidence confirming the previously reported role of TNF-alpha, IL-4 and sIL 2R in the control of tuberculosis, but these cytokines were not found related with disease severity.
Eser Adı (dc.title) | Correlation of serum tumor necrosis factor-alpha, interleukin-4 and soluble interleukin-2 receptor levels with radiologic and clinical manifestations in active pulmonary tuberculosis |
Yazar (dc.contributor.author) | Kart, L |
Yazar (dc.contributor.author) | Buyukoglan, H |
Yazar (dc.contributor.author) | Tekin, IO |
Yazar (dc.contributor.author) | Altin, R |
Yazar (dc.contributor.author) | Senturk, Z |
Yazar (dc.contributor.author) | Gulmez, I |
Yazar (dc.contributor.author) | Demir, R |
Yayın Yılı (dc.date.issued) | 2003 |
Yayıncı (dc.publisher) | HINDAWI LTD |
Yayın Türü (dc.type) | article |
Özet (dc.description.abstract) | THE precise clinical manifestations of tuberculosis are likely to result from a complex interaction between the host and the pathogen. We took serum samples from a group of patients with a variety of clinical and radiological stages of pulmonary tuberculosis in order to characterize tumor necrosis factor-alpha (TNF-alpha), interleukin-4 (IL-4) and soluble interleukin-2 receptor (sIL-2R) response. We further evaluated whether the levels of TNF-alpha, IL-4 and soluble IL-2R are related with each other, and also evaluated the levels of TNF-alpha, IL-4 and sIL-2R after anti-tuberculosis therapy and relation with radiologic scores. Forty-three inpatients with active pulmonary tuberculosis and 19 healthy controls participated in the study. Patients were divided into four categories radiologically on chest X-ray ( minimal, moderate-advanced, far-advanced and with miliary infiltration). Concentrations of TNF-alpha (20.9 +/- 10/15.4 +/- 8 pg/ml) and sIL-2R (2569 +/- 842/1444 +/- 514 pg/ml) were statistically different between patients and controls ( p = 0.02 and p = 0.0001, respectively). Before chemotherapy there was a positive correlation between TNF-alpha and sIL-2R (r = 0.34), but there was no correlation between IL-4 and TNF-alpha, and between IL-4 and sIL-2R (r = -0.23 and r = -0.22). The TNF-alpha level was not statistically different in four groups before and after chemotherapy. Results of this study provided some evidence confirming the previously reported role of TNF-alpha, IL-4 and sIL 2R in the control of tuberculosis, but these cytokines were not found related with disease severity. |
Açıklama (dc.description) | WOS: 000182332700002 |
Açıklama (dc.description) | PubMed: 12745543 |
Kayıt Giriş Tarihi (dc.date.accessioned) | 2019-12-23 |
(dc.date.available) | 2019-12-23 |
Yayın Dili (dc.language.iso) | eng |
Konu Başlıkları (dc.subject) | tuberculosis |
Konu Başlıkları (dc.subject) | radiologic manifestation |
Konu Başlıkları (dc.subject) | cytokine |
Haklar (dc.rights) | info:eu-repo/semantics/openAccess |
ISSN (dc.identifier.issn) | 0962-9351 |
ISSN (dc.identifier.issn) | 1466-1861 |
İlk Sayfa Sayısı (dc.identifier.startpage) | 9 |
Son Sayfa Sayısı (dc.identifier.endpage) | 14 |
Dergi Adı (dc.relation.journal) | MEDIATORS OF INFLAMMATION |
Dergi Sayısı (dc.identifier.issue) | 1 |
Dergi Cilt Bilgisi (dc.identifier.volume) | 12 |
Tek Biçim Adres (dc.identifier.uri) | https://dx.doi.org/10.1080/0962935031000096926 |
Tek Biçim Adres (dc.identifier.uri) | https://hdl.handle.net/20.500.12628/2316 |