Correlation of serum tumor necrosis factor-alpha, interleukin-4 and soluble interleukin-2 receptor levels with radiologic and clinical manifestations in active pulmonary tuberculosis

THE precise clinical manifestations of tuberculosis are likely to result from a complex interaction between the host and the pathogen. We took serum samples from a group of patients with a variety of clinical and radiological stages of pulmonary tuberculosis in order to characterize tumor necrosis factor-alpha (TNF-alpha), interleukin-4 (IL-4) and soluble interleukin-2 receptor (sIL-2R) response. We further evaluated whether the levels of TNF-alpha, IL-4 and soluble IL-2R are related with each other, and also evaluated the levels of TNF-alpha, IL-4 and sIL-2R after anti-tuberculosis therapy and relation with radiologic scores. Forty-three inpatients with active pulmonary tuberculosis and 19 healthy controls participated in the study. Patients were divided into four categories radiologically on chest X-ray ( minimal, moderate-advanced, far-advanced and with miliary infiltration). Concentrations of TNF-alpha (20.9 +/- 10/15.4 +/- 8 pg/ml) and sIL-2R (2569 +/- 842/1444 +/- 514 pg/ml) were statistically different between patients and controls ( p = 0.02 and p = 0.0001, respectively). Before chemotherapy there was a positive correlation between TNF-alpha and sIL-2R (r = 0.34), but there was no correlation between IL-4 and TNF-alpha, and between IL-4 and sIL-2R (r = -0.23 and r = -0.22). The TNF-alpha level was not statistically different in four groups before and after chemotherapy. Results of this study provided some evidence confirming the previously reported role of TNF-alpha, IL-4 and sIL 2R in the control of tuberculosis, but these cytokines were not found related with disease severity.

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Eser Adı
(dc.title)
Correlation of serum tumor necrosis factor-alpha, interleukin-4 and soluble interleukin-2 receptor levels with radiologic and clinical manifestations in active pulmonary tuberculosis
Yazar
(dc.contributor.author)
Kart, L
Yazar
(dc.contributor.author)
Buyukoglan, H
Yazar
(dc.contributor.author)
Tekin, IO
Yazar
(dc.contributor.author)
Altin, R
Yazar
(dc.contributor.author)
Senturk, Z
Yazar
(dc.contributor.author)
Gulmez, I
Yazar
(dc.contributor.author)
Demir, R
Yayın Yılı
(dc.date.issued)
2003
Yayıncı
(dc.publisher)
HINDAWI LTD
Yayın Türü
(dc.type)
article
Özet
(dc.description.abstract)
THE precise clinical manifestations of tuberculosis are likely to result from a complex interaction between the host and the pathogen. We took serum samples from a group of patients with a variety of clinical and radiological stages of pulmonary tuberculosis in order to characterize tumor necrosis factor-alpha (TNF-alpha), interleukin-4 (IL-4) and soluble interleukin-2 receptor (sIL-2R) response. We further evaluated whether the levels of TNF-alpha, IL-4 and soluble IL-2R are related with each other, and also evaluated the levels of TNF-alpha, IL-4 and sIL-2R after anti-tuberculosis therapy and relation with radiologic scores. Forty-three inpatients with active pulmonary tuberculosis and 19 healthy controls participated in the study. Patients were divided into four categories radiologically on chest X-ray ( minimal, moderate-advanced, far-advanced and with miliary infiltration). Concentrations of TNF-alpha (20.9 +/- 10/15.4 +/- 8 pg/ml) and sIL-2R (2569 +/- 842/1444 +/- 514 pg/ml) were statistically different between patients and controls ( p = 0.02 and p = 0.0001, respectively). Before chemotherapy there was a positive correlation between TNF-alpha and sIL-2R (r = 0.34), but there was no correlation between IL-4 and TNF-alpha, and between IL-4 and sIL-2R (r = -0.23 and r = -0.22). The TNF-alpha level was not statistically different in four groups before and after chemotherapy. Results of this study provided some evidence confirming the previously reported role of TNF-alpha, IL-4 and sIL 2R in the control of tuberculosis, but these cytokines were not found related with disease severity.
Açıklama
(dc.description)
WOS: 000182332700002
Açıklama
(dc.description)
PubMed: 12745543
Kayıt Giriş Tarihi
(dc.date.accessioned)
2019-12-23

(dc.date.available)
2019-12-23
Yayın Dili
(dc.language.iso)
eng
Konu Başlıkları
(dc.subject)
tuberculosis
Konu Başlıkları
(dc.subject)
radiologic manifestation
Konu Başlıkları
(dc.subject)
cytokine
Haklar
(dc.rights)
info:eu-repo/semantics/openAccess
ISSN
(dc.identifier.issn)
0962-9351
ISSN
(dc.identifier.issn)
1466-1861
İlk Sayfa Sayısı
(dc.identifier.startpage)
9
Son Sayfa Sayısı
(dc.identifier.endpage)
14
Dergi Adı
(dc.relation.journal)
MEDIATORS OF INFLAMMATION
Dergi Sayısı
(dc.identifier.issue)
1
Dergi Cilt Bilgisi
(dc.identifier.volume)
12
Tek Biçim Adres
(dc.identifier.uri)
https://dx.doi.org/10.1080/0962935031000096926
Tek Biçim Adres
(dc.identifier.uri)
https://hdl.handle.net/20.500.12628/2316
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