Which Anthropometric Parameter Is Best Related With Urinary Albumin Excretion and Creatinine Clearance in Type 2 Diabetes: Body Mass Index, Waist Circumference, Waist-to-Hip Ratio, or Conicity Index?

Objective: We analyzed the relationships between body mass index (BMI), waist circumference (WC), waist-to-hip ratio, and conicity index and 24-hour urinary albumin excretion rate (UAER) and creatinine clearance. Design: Cross-sectional study. Setting: Patients presenting to a state hospital. Patients: Study involved patients with type 2 diabetes. Methods: Study participants underwent medical history examination, measurement of office blood pressure (BP), measurement of anthropometric factors and calculations (including BMI, WC, waist-to-hip ratio, and conicity index), physical examination, biochemical analysis, and 24-hour urine specimen collection to determine creatinine clearance and UAER. Results: In all, 202 patients with type 2 diabetes (male/female: 91/111, aged: 58.4 +/- 10.1 years) were included. It was found that 24-hour UAER correlated with WC (rho: +0.176, P=.012), serum albumin (rho: -0.324, P<.0001), and systolic BP (rho: +0.153, P=.029), whereas creatinine clearance correlated with age (rho: -0.152, P=.031), BMI (rho: +0.191, P=.007), albumin level (rho: +0.365, P<.0001), and uric acid level (rho: -0.369, P<.0001). The stepwise linear regression analysis revealed that WC(P=.012), glycosylated hemoglobin (P=.018), and systolic BP (P=.043) were found to be independently related to logarithmically converted 24-hour UAER, whereas creatinine clearance was found to be related to duration of diabetes (P=.001), BMI (P=.008), presence of peripheral arterial disease (P=.021), fasting serum glucose level (P=.003), and uric acid level (P<.0001). However, after correction for body surface area, BMI was no longer associated with creatinine clearance. Conclusion: Among the anthropometric parameters, only an increase in WC was found to be independently related to 24-hour UAER. Although BMI was associated with creatinine clearance, this association was lost after creatinine clearance was corrected for body surface area. (C) 2011 by the National Kidney Foundation, Inc. All rights reserved.

Yazar Afsar, Baris
Elsurer, Rengin
Guner, Ertugrul
Kirkpantur, Alper
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3792
Tek Biçim Adres 10.1053/j.jrn.2010.12.003
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı JOURNAL OF RENAL NUTRITION
Dergi Cilt Bilgisi 21
Dergi Sayısı 6
Sayfalar 472 - 478
Yayın Yılı 2011
Eser Adı
[dc.title]
Which Anthropometric Parameter Is Best Related With Urinary Albumin Excretion and Creatinine Clearance in Type 2 Diabetes: Body Mass Index, Waist Circumference, Waist-to-Hip Ratio, or Conicity Index?
Yazar
[dc.contributor.author]
Afsar, Baris
Yazar
[dc.contributor.author]
Elsurer, Rengin
Yazar
[dc.contributor.author]
Guner, Ertugrul
Yazar
[dc.contributor.author]
Kirkpantur, Alper
Yayın Yılı
[dc.date.issued]
2011
Yayıncı
[dc.publisher]
W B SAUNDERS CO-ELSEVIER INC
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective: We analyzed the relationships between body mass index (BMI), waist circumference (WC), waist-to-hip ratio, and conicity index and 24-hour urinary albumin excretion rate (UAER) and creatinine clearance. Design: Cross-sectional study. Setting: Patients presenting to a state hospital. Patients: Study involved patients with type 2 diabetes. Methods: Study participants underwent medical history examination, measurement of office blood pressure (BP), measurement of anthropometric factors and calculations (including BMI, WC, waist-to-hip ratio, and conicity index), physical examination, biochemical analysis, and 24-hour urine specimen collection to determine creatinine clearance and UAER. Results: In all, 202 patients with type 2 diabetes (male/female: 91/111, aged: 58.4 +/- 10.1 years) were included. It was found that 24-hour UAER correlated with WC (rho: +0.176, P=.012), serum albumin (rho: -0.324, P<.0001), and systolic BP (rho: +0.153, P=.029), whereas creatinine clearance correlated with age (rho: -0.152, P=.031), BMI (rho: +0.191, P=.007), albumin level (rho: +0.365, P<.0001), and uric acid level (rho: -0.369, P<.0001). The stepwise linear regression analysis revealed that WC(P=.012), glycosylated hemoglobin (P=.018), and systolic BP (P=.043) were found to be independently related to logarithmically converted 24-hour UAER, whereas creatinine clearance was found to be related to duration of diabetes (P=.001), BMI (P=.008), presence of peripheral arterial disease (P=.021), fasting serum glucose level (P=.003), and uric acid level (P<.0001). However, after correction for body surface area, BMI was no longer associated with creatinine clearance. Conclusion: Among the anthropometric parameters, only an increase in WC was found to be independently related to 24-hour UAER. Although BMI was associated with creatinine clearance, this association was lost after creatinine clearance was corrected for body surface area. (C) 2011 by the National Kidney Foundation, Inc. All rights reserved.
Açıklama
[dc.description]
WOS: 000296533100006
Açıklama
[dc.description]
PubMed: 21454092
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1051-2276
ISSN
[dc.identifier.issn]
1532-8503
İlk Sayfa Sayısı
[dc.identifier.startpage]
472
Son Sayfa Sayısı
[dc.identifier.endpage]
478
Dergi Adı
[dc.relation.journal]
JOURNAL OF RENAL NUTRITION
Dergi Sayısı
[dc.identifier.issue]
6
Dergi Cilt Bilgisi
[dc.identifier.volume]
21
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1053/j.jrn.2010.12.003
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3792
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Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
21
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
26 Ekim 2023 02:20
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clearance creatinine 24-hour related albumin diabetes surface examination measurement whereas anthropometric analysis independently conicity correlated waist-to-hip systolic Patients associated patients converted logarithmically revealed stepwise regression linear hemoglobin duration glycosylated However Although association corrected increase National
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