The independent relationship between creatinine clearance, microalbuminuria and circadian blood pressure levels in newly diagnosed essential hypertensive and type 2 diabetic patients

Background and Objectives: Increased evidence suggests that apart from patients with increased albumin excretion and decreased glomerular filtration rate (GFR); there are also patients with type 2 diabetes with decreased GFR but without albuminuria. The exact pathophysiologic mechanisms regarding these clinical conditions are not known. We suggest that different blood pressure (BP) levels may be one the factors for these different clinical conditions. However, before labeling BP as a causative factor: one must show whether BP levels are different in these patients. Thus the current study was performed to analyze the relationship between creatinine clearance, microalbuminuria and circadian blood pressure levels in newly diagnosed essential hypertensive and type 2 diabetic patients. Methods: Medical history, physical examination, laboratory analysis and ambulatory blood pressure measurements (ABPMs) were analyzed. 24-h urine specimens were collected to measure creatinine clearance and albumin excretion Results: In total 216 patients were included which were divided into 4 groups: group 1 composed of 90 patients with normal GFR and without microalbuminuria (MA), group 2 composed of 50 patients with normal GFR and with MA, group 3 composed of 36 patients with decreased GFR and without MA and group 4 composed of 40 patients with both decreased GFR and MA. The ratio of dippers vs. non dippers was not different between group 1, group 2 and group 3 patients. However ratio of dippers was higher in group 1 when compared to group 4 (P: 0.003) and group 4 patients have an odds of 7.678 (CI: 1.657-35.576, P: 0.009) for non-dapping status when compared to patients in group 1. Conclusion: In conclusion, ABPM measurements were highest in patients with both decreased GFR and MA, whereas they are lowest in patients with normal GFR and normal UAE. (C) 2012 Elsevier Inc. All rights reserved.

Dergi Adı JOURNAL OF DIABETES AND ITS COMPLICATIONS
Dergi Cilt Bilgisi 26
Dergi Sayısı 6
Sayfalar 531 - 535
Yayın Yılı 2012
Eser Adı
[dc.title]
The independent relationship between creatinine clearance, microalbuminuria and circadian blood pressure levels in newly diagnosed essential hypertensive and type 2 diabetic patients
Yazar
[dc.contributor.author]
Afsar, Bans
Yazar
[dc.contributor.author]
Elsurer, Rengin
Yayın Yılı
[dc.date.issued]
2012
Yayıncı
[dc.publisher]
ELSEVIER SCIENCE INC
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background and Objectives: Increased evidence suggests that apart from patients with increased albumin excretion and decreased glomerular filtration rate (GFR); there are also patients with type 2 diabetes with decreased GFR but without albuminuria. The exact pathophysiologic mechanisms regarding these clinical conditions are not known. We suggest that different blood pressure (BP) levels may be one the factors for these different clinical conditions. However, before labeling BP as a causative factor: one must show whether BP levels are different in these patients. Thus the current study was performed to analyze the relationship between creatinine clearance, microalbuminuria and circadian blood pressure levels in newly diagnosed essential hypertensive and type 2 diabetic patients. Methods: Medical history, physical examination, laboratory analysis and ambulatory blood pressure measurements (ABPMs) were analyzed. 24-h urine specimens were collected to measure creatinine clearance and albumin excretion Results: In total 216 patients were included which were divided into 4 groups: group 1 composed of 90 patients with normal GFR and without microalbuminuria (MA), group 2 composed of 50 patients with normal GFR and with MA, group 3 composed of 36 patients with decreased GFR and without MA and group 4 composed of 40 patients with both decreased GFR and MA. The ratio of dippers vs. non dippers was not different between group 1, group 2 and group 3 patients. However ratio of dippers was higher in group 1 when compared to group 4 (P: 0.003) and group 4 patients have an odds of 7.678 (CI: 1.657-35.576, P: 0.009) for non-dapping status when compared to patients in group 1. Conclusion: In conclusion, ABPM measurements were highest in patients with both decreased GFR and MA, whereas they are lowest in patients with normal GFR and normal UAE. (C) 2012 Elsevier Inc. All rights reserved.
Açıklama
[dc.description]
WOS: 000311267700012
Açıklama
[dc.description]
PubMed: 22795337
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Ambulatory blood pressure
Konu Başlıkları
[dc.subject]
Creatinine clearance
Konu Başlıkları
[dc.subject]
Diabetes mellitus
Konu Başlıkları
[dc.subject]
Glomerular filtration rate
Konu Başlıkları
[dc.subject]
Hypertension
Konu Başlıkları
[dc.subject]
Microalbuminuria
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1056-8727
ISSN
[dc.identifier.issn]
1873-460X
İlk Sayfa Sayısı
[dc.identifier.startpage]
531
Son Sayfa Sayısı
[dc.identifier.endpage]
535
Dergi Adı
[dc.relation.journal]
JOURNAL OF DIABETES AND ITS COMPLICATIONS
Dergi Sayısı
[dc.identifier.issue]
6
Dergi Cilt Bilgisi
[dc.identifier.volume]
26
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.jdiacomp.2012.05.016
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3616
Görüntülenme Sayısı ( Şehir )
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Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
287
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
17 Temmuz 2024 22:59
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patients decreased composed different normal without dippers levels pressure between clearance However compared creatinine microalbuminuria conditions clinical measurements albumin excretion divided groups included Background Conclusion reserved rights Elsevier lowest whereas highest conclusion status higher measure
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