Gastroprotective and antioxidant effects of amiodarone on lndomethacin-induced gastric ulcers in rats

Reactive oxygen species (ROS) have been implicated in the etiology-of indomethacin-induced gastric mucosal damage. This study investigated amiodarone's protective effects against oxidative gastric mucosal damage induced by indomethacin. Amiodarone is a widely used antiarrhythmic agent. We have investigated alterations in the glutathione level, and the activities of antioxidative enzymes [superoxide dismutase, catalase, glutathione s-transferase glutathione reductase and myeloperoxidase], as markers for ulceration process following oral administration of amiodarone and ranitidine in rats with indomethacin-induced ulcers. In the present study we found that 1) amiodarone, lansoprazole and ranitidine reduced the development of indomethacin-induced gastric damages, at a greater magnitude for amiodarone and lansoprazole than for ranitidine; 2) arniodarone and ranitidine alleviated increases in the activities of catalase and glutathione s-transferase enzymes resulting from ulcers; 3) arniodarone and ranitidine ameliorated depressions in the glutathione level and the activities of superoxide dismutase and glutathione reductase enzymes caused by indomethacin administration; and 4) all doses of amiodarone amplified the myeloperoxidase activity resulting from indomethacin-induced gastric ulcers. The results indicate that the gastroprotective activity of arniodarone, which may be linked to its intrinsic antioxidant properties, cannot be attributed to its effect on myeloperoxidase activity.

Yazar Dengiz, G. Ozbakis
Odabasoglu, F.
Halici, Z.
Suleyman, H.
Cadirci, E.
Bayir, Y.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2673
Tek Biçim Adres 10.1007/BF02977367
Konu Başlıkları amiodarone
indomethacin
gastroprotective effect
myeloperoxiclase
antioxidant enzymes
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı ARCHIVES OF PHARMACAL RESEARCH
Dergi Cilt Bilgisi 30
Dergi Sayısı 11
Sayfalar 1426 - 1434
Yayın Yılı 2007
Eser Adı
[dc.title]
Gastroprotective and antioxidant effects of amiodarone on lndomethacin-induced gastric ulcers in rats
Yazar
[dc.contributor.author]
Dengiz, G. Ozbakis
Yazar
[dc.contributor.author]
Odabasoglu, F.
Yazar
[dc.contributor.author]
Halici, Z.
Yazar
[dc.contributor.author]
Suleyman, H.
Yazar
[dc.contributor.author]
Cadirci, E.
Yazar
[dc.contributor.author]
Bayir, Y.
Yayın Yılı
[dc.date.issued]
2007
Yayıncı
[dc.publisher]
PHARMACEUTICAL SOC KOREA
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Reactive oxygen species (ROS) have been implicated in the etiology-of indomethacin-induced gastric mucosal damage. This study investigated amiodarone's protective effects against oxidative gastric mucosal damage induced by indomethacin. Amiodarone is a widely used antiarrhythmic agent. We have investigated alterations in the glutathione level, and the activities of antioxidative enzymes [superoxide dismutase, catalase, glutathione s-transferase glutathione reductase and myeloperoxidase], as markers for ulceration process following oral administration of amiodarone and ranitidine in rats with indomethacin-induced ulcers. In the present study we found that 1) amiodarone, lansoprazole and ranitidine reduced the development of indomethacin-induced gastric damages, at a greater magnitude for amiodarone and lansoprazole than for ranitidine; 2) arniodarone and ranitidine alleviated increases in the activities of catalase and glutathione s-transferase enzymes resulting from ulcers; 3) arniodarone and ranitidine ameliorated depressions in the glutathione level and the activities of superoxide dismutase and glutathione reductase enzymes caused by indomethacin administration; and 4) all doses of amiodarone amplified the myeloperoxidase activity resulting from indomethacin-induced gastric ulcers. The results indicate that the gastroprotective activity of arniodarone, which may be linked to its intrinsic antioxidant properties, cannot be attributed to its effect on myeloperoxidase activity.
Açıklama
[dc.description]
WOS: 000251242300011
Açıklama
[dc.description]
PubMed: 18087811
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
amiodarone
Konu Başlıkları
[dc.subject]
indomethacin
Konu Başlıkları
[dc.subject]
gastroprotective effect
Konu Başlıkları
[dc.subject]
myeloperoxiclase
Konu Başlıkları
[dc.subject]
antioxidant enzymes
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0253-6269
ISSN
[dc.identifier.issn]
1976-3786
İlk Sayfa Sayısı
[dc.identifier.startpage]
1426
Son Sayfa Sayısı
[dc.identifier.endpage]
1434
Dergi Adı
[dc.relation.journal]
ARCHIVES OF PHARMACAL RESEARCH
Dergi Sayısı
[dc.identifier.issue]
11
Dergi Cilt Bilgisi
[dc.identifier.volume]
30
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1007/BF02977367
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2673
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
5
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Şubat 2024 03:33
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Tıklayınız
glutathione ranitidine amiodarone indomethacin-induced gastric ulcers activity arniodarone activities enzymes resulting dismutase catalase administration s-transferase myeloperoxidase reductase indomethacin investigated lansoprazole mucosal damage depressions ameliorated alleviated superoxide magnitude caused increases Reactive linked effect attributed cannot properties
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