Neopterin as a marker for immune system activation in coal workers' pneumoconiosis

Coal workers' pneumoconiosis (CWP) is an occupational pulmonary disease that occurs by chronic inhalation of coal dust. Coal workers' pneumoconiosis is divided into two categories depending on the extent of the disease as simple pneumoconiosis (SP) and progressive massive fibrosis (PMF). Development of CWP is associated with the activation of the immune system. Neopterin is a predictive biochemical marker of cell-mediated immune activation and elevated levels of neopterin are detected in body fluids of patients with immune-related diseases. The present study was aimed to investigate whether increased serum, urine and bronchoalveolar lavage (BAL) fluid levels of neopterin is associated with the development and/or severity of CWP. Mean serum neopterin levels in SP and PMF patients (10.72 +/- 0.98 nmol/L; 14.08 +/- 3.86 nmol/L, respectively) were significantly higher than those of control group (5.30 +/- 0.47 nmol/L) (P < 0.05). Although urinary neopterin levels were also increased in SP and PMF patients (235.17 +/- 7.40 mu mol/mol creatinine; 256.05 +/- 9.43 mu mol/mol creatinine, respectively) as compared with the control group (140.00 +/- 5.43 mu mol/mol creatinine) (P < 0.01), they were within the normal concentration range. No significant difference was observed between serum and urinary neopterin levels of SP and PMF patients. A correlation was observed between serum and urinary neopterin levels of all subjects (r = 0.525, P < 0.01). Bronchoalveolar lavage fluid neopterin levels were significantly higher in patients with SP and PMF (22.67 +/- 2.9 nmol/L; 41.67 +/- 8.68 nmol/L, respectively) compared with control subjects (6.264 +/- 1.74 nmol/L) (P < 0.05, P < 0.0 1, respectively). The levels of neopterin in BAL fluid were also significantly higher in patients with PMF than in those with SP (P < 0.05). These findings indicate that elevated serum and BAL levels of neopterin may be considered as a suitable biomarker for the assessment of CWP.

Yazar Ulker, Ozge C.
Yucesoy, Berran
Durucu, Murat
Karakaya, Asuman
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2986
Tek Biçim Adres 10.1177/0748233707083527
Konu Başlıkları biomarker
cell mediated immunity
coal workers' pneumoconiosis
neopterin
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı TOXICOLOGY AND INDUSTRIAL HEALTH
Dergi Cilt Bilgisi 23
Dergi Sayısı 3
Sayfalar 155 - 160
Yayın Yılı 2007
Eser Adı
[dc.title]
Neopterin as a marker for immune system activation in coal workers' pneumoconiosis
Yazar
[dc.contributor.author]
Ulker, Ozge C.
Yazar
[dc.contributor.author]
Yucesoy, Berran
Yazar
[dc.contributor.author]
Durucu, Murat
Yazar
[dc.contributor.author]
Karakaya, Asuman
Yayın Yılı
[dc.date.issued]
2007
Yayıncı
[dc.publisher]
SAGE PUBLICATIONS INC
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Coal workers' pneumoconiosis (CWP) is an occupational pulmonary disease that occurs by chronic inhalation of coal dust. Coal workers' pneumoconiosis is divided into two categories depending on the extent of the disease as simple pneumoconiosis (SP) and progressive massive fibrosis (PMF). Development of CWP is associated with the activation of the immune system. Neopterin is a predictive biochemical marker of cell-mediated immune activation and elevated levels of neopterin are detected in body fluids of patients with immune-related diseases. The present study was aimed to investigate whether increased serum, urine and bronchoalveolar lavage (BAL) fluid levels of neopterin is associated with the development and/or severity of CWP. Mean serum neopterin levels in SP and PMF patients (10.72 +/- 0.98 nmol/L; 14.08 +/- 3.86 nmol/L, respectively) were significantly higher than those of control group (5.30 +/- 0.47 nmol/L) (P < 0.05). Although urinary neopterin levels were also increased in SP and PMF patients (235.17 +/- 7.40 mu mol/mol creatinine; 256.05 +/- 9.43 mu mol/mol creatinine, respectively) as compared with the control group (140.00 +/- 5.43 mu mol/mol creatinine) (P < 0.01), they were within the normal concentration range. No significant difference was observed between serum and urinary neopterin levels of SP and PMF patients. A correlation was observed between serum and urinary neopterin levels of all subjects (r = 0.525, P < 0.01). Bronchoalveolar lavage fluid neopterin levels were significantly higher in patients with SP and PMF (22.67 +/- 2.9 nmol/L; 41.67 +/- 8.68 nmol/L, respectively) compared with control subjects (6.264 +/- 1.74 nmol/L) (P < 0.05, P < 0.0 1, respectively). The levels of neopterin in BAL fluid were also significantly higher in patients with PMF than in those with SP (P < 0.05). These findings indicate that elevated serum and BAL levels of neopterin may be considered as a suitable biomarker for the assessment of CWP.
Açıklama
[dc.description]
WOS: 000252201700005
Açıklama
[dc.description]
PubMed: 18220157
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
biomarker
Konu Başlıkları
[dc.subject]
cell mediated immunity
Konu Başlıkları
[dc.subject]
coal workers' pneumoconiosis
Konu Başlıkları
[dc.subject]
neopterin
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0748-2337
İlk Sayfa Sayısı
[dc.identifier.startpage]
155
Son Sayfa Sayısı
[dc.identifier.endpage]
160
Dergi Adı
[dc.relation.journal]
TOXICOLOGY AND INDUSTRIAL HEALTH
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
23
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1177/0748233707083527
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2986
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
7
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
04 Şubat 2024 05:11
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Tıklayınız
neopterin levels patients respectively) nmol/L urinary pneumoconiosis mol/mol significantly control higher subjects lavage workers increased between observed compared nmol/L) creatinine immune activation associated elevated disease fluids correlation occurs difference significant normal concentration within creatinine) chronic
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