Protective effect of dexmedetomidine in a rat model of alpha-naphthylthioureae-induced acute lung injury

Background: We assessed the effects of dexmedetomidine in a rat model of alpha-naphthylthiourea (ANTU)-induced acute lung injury. Methods: Forty Wistar Albino male rats weighing 200-240 g were divided into 5 groups (n = 8 each), including a control group. Thus, there were one ANTU group and three dexmedetomidine groups (10-, 50-, and 100- mu g/kg treatment groups), plus a control group. The control group provided the normal base values. The rats in the ANTU group were given 10 mg/kg of ANTU intraperitoneally and the three treatment groups received 10, 50, or 100 mu g/kg of dexmedetomidine intraperitoneally 30 min before ANTU application. The rat body weight (BW), pleural effusion (PE), and lung weight (LW) of each group were measured 4 h after ANTU administration. The histopathologic changes were evaluated using hematoxylin-eosin staining. Results: The mean PE, LW, LW/BW, and PE/BW measurements in the ANTU group were significantly greater than in the control groups and all dexmedetomidine treatment groups (P < 0.05). There were also significant decreases in the mean PE, LW, LW/BW and PE/BW values in the dexmedetomidine 50-mu g/kg group compared with those in the ANTU group (P < 0.01). The inflammation, hemorrhage, and edema scores in the ANTU group were significantly greater than those in the control or dexmedetomidine 50-mu g/kg group (P < 0.01). Conclusion: Dexmedetomidine treatment has demonstrated a potential benefit by preventing ANTU-induced acute lung injury in an experimental rat model. Dexmedetomidine could have a potential protective effect on acute lung injury in intensive care patients. (C) 2012 Elsevier Inc. All rights reserved.

Yazar Hanci, Volkan
Yurdakan, Gamze
Yurtlu, Serhan
Turan, Isil Ozkocak
Sipahi, Emine Yilmaz
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3182
Tek Biçim Adres 10.1016/j.jss.2012.02.027
Konu Başlıkları Dexmedetomidine
alpha-Naphthylthiourea
Acute lung injury
Pulmonary edema
Pleural effusion
Inflammation
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı JOURNAL OF SURGICAL RESEARCH
Dergi Cilt Bilgisi 178
Dergi Sayısı 1
Sayfalar 424 - 430
Yayın Yılı 2012
Eser Adı
[dc.title]
Protective effect of dexmedetomidine in a rat model of alpha-naphthylthioureae-induced acute lung injury
Yazar
[dc.contributor.author]
Hanci, Volkan
Yazar
[dc.contributor.author]
Yurdakan, Gamze
Yazar
[dc.contributor.author]
Yurtlu, Serhan
Yazar
[dc.contributor.author]
Turan, Isil Ozkocak
Yazar
[dc.contributor.author]
Sipahi, Emine Yilmaz
Yayın Yılı
[dc.date.issued]
2012
Yayıncı
[dc.publisher]
ACADEMIC PRESS INC ELSEVIER SCIENCE
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background: We assessed the effects of dexmedetomidine in a rat model of alpha-naphthylthiourea (ANTU)-induced acute lung injury. Methods: Forty Wistar Albino male rats weighing 200-240 g were divided into 5 groups (n = 8 each), including a control group. Thus, there were one ANTU group and three dexmedetomidine groups (10-, 50-, and 100- mu g/kg treatment groups), plus a control group. The control group provided the normal base values. The rats in the ANTU group were given 10 mg/kg of ANTU intraperitoneally and the three treatment groups received 10, 50, or 100 mu g/kg of dexmedetomidine intraperitoneally 30 min before ANTU application. The rat body weight (BW), pleural effusion (PE), and lung weight (LW) of each group were measured 4 h after ANTU administration. The histopathologic changes were evaluated using hematoxylin-eosin staining. Results: The mean PE, LW, LW/BW, and PE/BW measurements in the ANTU group were significantly greater than in the control groups and all dexmedetomidine treatment groups (P < 0.05). There were also significant decreases in the mean PE, LW, LW/BW and PE/BW values in the dexmedetomidine 50-mu g/kg group compared with those in the ANTU group (P < 0.01). The inflammation, hemorrhage, and edema scores in the ANTU group were significantly greater than those in the control or dexmedetomidine 50-mu g/kg group (P < 0.01). Conclusion: Dexmedetomidine treatment has demonstrated a potential benefit by preventing ANTU-induced acute lung injury in an experimental rat model. Dexmedetomidine could have a potential protective effect on acute lung injury in intensive care patients. (C) 2012 Elsevier Inc. All rights reserved.
Açıklama
[dc.description]
WOS: 000310450300064
Açıklama
[dc.description]
PubMed: 22445456
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Dexmedetomidine
Konu Başlıkları
[dc.subject]
alpha-Naphthylthiourea
Konu Başlıkları
[dc.subject]
Acute lung injury
Konu Başlıkları
[dc.subject]
Pulmonary edema
Konu Başlıkları
[dc.subject]
Pleural effusion
Konu Başlıkları
[dc.subject]
Inflammation
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0022-4804
Sponsor YAYINCI
[dc.description.sponsorship]
Zonguldak Karaelmas University's Office of Research and Sponsored ProgramsBulent Ecevit University
Sponsor YAYINCI
[dc.description.sponsorship]
The authors would like to thank Dr. E. Schilliger from Schering AG, Berlin, Germany, for his gift of a-naphthylthiourea (Interchem). We thank Hasan Tahsin Yilmaz and Bayram Cakan for their assistance in the Animal Research Laboratory. This study was supported by intramural funding from the Zonguldak Karaelmas University's Office of Research and Sponsored Programs.
İlk Sayfa Sayısı
[dc.identifier.startpage]
424
Son Sayfa Sayısı
[dc.identifier.endpage]
430
Dergi Adı
[dc.relation.journal]
JOURNAL OF SURGICAL RESEARCH
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
178
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.jss.2012.02.027
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3182
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
16
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
06 Şubat 2024 18:46
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dexmedetomidine control groups treatment injury Dexmedetomidine intraperitoneally potential values weight greater significantly Results compared decreases significant measurements Background inflammation protective reserved rights Elsevier patients intensive effect hemorrhage experimental ANTU-induced preventing benefit demonstrated hematoxylin-eosin Conclusion scores
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