The Effects of Ivabradine on Left Ventricular Synchronization and Tei Index in Patients with Systolic Heart Failure

Background: The aim of our study was to evaluate in stable outpatients with systolic heart failure (HF) the 3 months effect of ivabradine on LV synchronization and Tei index in stable outpatients with systolic HF. Methods: We evaluated prospectively 40 (30 males, 10 females) patients with HF. All patients were evaluated before and after treatment by transthoracic M mode, two dimensional (2D), pulsed-wave (PW), continuous wave (CW), color flow and tissue Doppler imaging (TDI) and tissue synchronization imaging (TSI). Standard deviation of Ts of the 12 LV segments (Ts-SD-12) is the most widely used parameter of intra-LV asynchrony. Results: Thirty men and 10 women with mean +/- SD age of 64.7 +/- 9.9 years were included in this study. Most of the patients benefitted from some degree of clinical improvement, 12/16 (75.0%) from NYHA III to II and 18/24 (75.0%) from II to I, respectively. Resting heart rate was significantly reduced after ivabradine treatment (84.3 +/- 11.4 vs. 66.5 +/- 11.5 bpm, p <0.001). E/E' and Tei index were significantly changed after ivabradine treatment (17.3 +/- 9.0 vs. 14.8 +/- 7.1, p = 0.02 and 0.86 +/- 0.74 vs. 0.81 +/- 0.69, p = 0.02). Intra-LV synchrony parameters Ts-SD-12 and Ts-12 were significantly reduced after ivabradine (46.8 +/- 13.6 vs. 42.7 +/- 13.1, p = 0.01 and 142.5 +/- 44.0 vs. 128.5 +/- 45.2, p = 0.009). Conclusions: The present study demonstrated that adding ivabradine to the standard therapy reduced HR and significantly improved LV ventricular asynchrony and Tei index in systolic HF patients.

Yazar Erdem, Fatma Hizal
Ozturk, Serkan
Ozturk, Selcuk
Erdem, Alim
Ayhan, Selim
Ozturk, Mustafa
Donmez, Ibrahim
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3558
Tek Biçim Adres 10.6515/ACS20160205B
Konu Başlıkları Heart failure
Ivabradine
Left ventricular function
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı ACTA CARDIOLOGICA SINICA
Dergi Cilt Bilgisi 33
Dergi Sayısı 1
Sayfalar 58 - 65
Yayın Yılı 2017
Eser Adı
[dc.title]
The Effects of Ivabradine on Left Ventricular Synchronization and Tei Index in Patients with Systolic Heart Failure
Yazar
[dc.contributor.author]
Erdem, Fatma Hizal
Yazar
[dc.contributor.author]
Ozturk, Serkan
Yazar
[dc.contributor.author]
Ozturk, Selcuk
Yazar
[dc.contributor.author]
Erdem, Alim
Yazar
[dc.contributor.author]
Ayhan, Selim
Yazar
[dc.contributor.author]
Ozturk, Mustafa
Yazar
[dc.contributor.author]
Donmez, Ibrahim
Yayın Yılı
[dc.date.issued]
2017
Yayıncı
[dc.publisher]
TAIWAN SOC CARDIOLOGY
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background: The aim of our study was to evaluate in stable outpatients with systolic heart failure (HF) the 3 months effect of ivabradine on LV synchronization and Tei index in stable outpatients with systolic HF. Methods: We evaluated prospectively 40 (30 males, 10 females) patients with HF. All patients were evaluated before and after treatment by transthoracic M mode, two dimensional (2D), pulsed-wave (PW), continuous wave (CW), color flow and tissue Doppler imaging (TDI) and tissue synchronization imaging (TSI). Standard deviation of Ts of the 12 LV segments (Ts-SD-12) is the most widely used parameter of intra-LV asynchrony. Results: Thirty men and 10 women with mean +/- SD age of 64.7 +/- 9.9 years were included in this study. Most of the patients benefitted from some degree of clinical improvement, 12/16 (75.0%) from NYHA III to II and 18/24 (75.0%) from II to I, respectively. Resting heart rate was significantly reduced after ivabradine treatment (84.3 +/- 11.4 vs. 66.5 +/- 11.5 bpm, p <0.001). E/E' and Tei index were significantly changed after ivabradine treatment (17.3 +/- 9.0 vs. 14.8 +/- 7.1, p = 0.02 and 0.86 +/- 0.74 vs. 0.81 +/- 0.69, p = 0.02). Intra-LV synchrony parameters Ts-SD-12 and Ts-12 were significantly reduced after ivabradine (46.8 +/- 13.6 vs. 42.7 +/- 13.1, p = 0.01 and 142.5 +/- 44.0 vs. 128.5 +/- 45.2, p = 0.009). Conclusions: The present study demonstrated that adding ivabradine to the standard therapy reduced HR and significantly improved LV ventricular asynchrony and Tei index in systolic HF patients.
Açıklama
[dc.description]
WOS: 000392042800008
Açıklama
[dc.description]
PubMed: 28115808
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Heart failure
Konu Başlıkları
[dc.subject]
Ivabradine
Konu Başlıkları
[dc.subject]
Left ventricular function
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1011-6842
İlk Sayfa Sayısı
[dc.identifier.startpage]
58
Son Sayfa Sayısı
[dc.identifier.endpage]
65
Dergi Adı
[dc.relation.journal]
ACTA CARDIOLOGICA SINICA
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
33
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.6515/ACS20160205B
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3558
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
11
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
06 Şubat 2024 15:28
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Tıklayınız
ivabradine significantly patients reduced treatment systolic imaging tissue asynchrony evaluated stable outpatients synchronization changed Resting respectively Background ventricular improved therapy standard adding demonstrated present Conclusions Ts-SD-12 parameters synchrony Intra-LV females) continuous pulsed-wave dimensional transthoracic before
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