Ecstasy (MDMA) and its effects on kidneys and their treatment: a review

Ecstasy (MDMA; 3,4-methylenedioxymethylamphetamine) is an illicit drug that has been increasingly abused by young people. Its effects include euphoria, enhanced sociability and heightened mental awareness. These come about via the increase of serotonin in both the central nervous system and the sympathetic nervous system. Despite the drug's prevalent abuse, serious or adverse effects are rare. Due to personal pharmacokinetics, effects from the same dosage vary according to the individual. Fatal instances may include acute hyponatremia, hyperthermia (>42 degrees C), disseminated intravascular coagulation (DIC) resulting from hyperthermia affecting the kidneys, and non-traumatic rhabdomyolysis. However, it is seldom the case that hyponatremia and hyperthermia co-exist. Hyponatremia is thought to be caused by HMMA - a metabolite of MDMA. Hyponatremia is caused by the inappropriate secretion of arginine vasopressin (AVP) and the excessive intake of hypotonic liquid accompanied by increased hyperthermia. Symptomatic, even deadly hyponatremia is seen more frequently in females, with the effects of oestrogen on arginine vasopressin believed to be the cause. Onset in such cases is acute, and treatment should be given to symptomatic patients as quickly as possible, with 3% saline administered when necessary. Reasons for acute kidney injury may include rhabdomyolysis, malign hypertension, and necrotizing vasculitis.

Sayfalar 1151 - 1158
Yayın Yılı 2016
Eser Adı
[dc.title]
Ecstasy (MDMA) and its effects on kidneys and their treatment: a review
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
MASHHAD UNIV MED SCIENCES
Yayın Türü
[dc.type]
review
Açıklama
[dc.description]
WOS: 000391089600001
Açıklama
[dc.description]
PubMed: 27917269
Özet
[dc.description.abstract]
Ecstasy (MDMA; 3,4-methylenedioxymethylamphetamine) is an illicit drug that has been increasingly abused by young people. Its effects include euphoria, enhanced sociability and heightened mental awareness. These come about via the increase of serotonin in both the central nervous system and the sympathetic nervous system. Despite the drug's prevalent abuse, serious or adverse effects are rare. Due to personal pharmacokinetics, effects from the same dosage vary according to the individual. Fatal instances may include acute hyponatremia, hyperthermia (>42 degrees C), disseminated intravascular coagulation (DIC) resulting from hyperthermia affecting the kidneys, and non-traumatic rhabdomyolysis. However, it is seldom the case that hyponatremia and hyperthermia co-exist. Hyponatremia is thought to be caused by HMMA - a metabolite of MDMA. Hyponatremia is caused by the inappropriate secretion of arginine vasopressin (AVP) and the excessive intake of hypotonic liquid accompanied by increased hyperthermia. Symptomatic, even deadly hyponatremia is seen more frequently in females, with the effects of oestrogen on arginine vasopressin believed to be the cause. Onset in such cases is acute, and treatment should be given to symptomatic patients as quickly as possible, with 3% saline administered when necessary. Reasons for acute kidney injury may include rhabdomyolysis, malign hypertension, and necrotizing vasculitis.
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2433
Yayın Dili
[dc.language.iso]
eng
Yazar
[dc.contributor.author]
Bora, Feyza
Yazar
[dc.contributor.author]
Yilmaz, Fatih
Yazar
[dc.contributor.author]
Bora, Taner
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
İlk Sayfa Sayısı
[dc.identifier.startpage]
1151
Son Sayfa Sayısı
[dc.identifier.endpage]
1158
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
22
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
03 Nisan 2024 07:38
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hyperthermia effects include hyponatremia nervous vasopressin arginine system rhabdomyolysis Hyponatremia caused secretion Symptomatic increased accompanied thought liquid hypotonic intake excessive metabolite inappropriate deadly Ecstasy possible vasculitis necrotizing hypertension malign injury kidney Reasons necessary administered saline
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