Rectal dexmedetomidine in rats: evaluation of sedative and mucosal effects

Background and objectives: In this study, we investigated the anesthetic and mucosal effects of the rectal application of dexmedetomidine to rats. Methods: Male Wistar albino rats weighing 250-300 g were divided into four groups: Group S (n=8) was a sham group that served as a baseline for the normal basal values; Group C (n=8) consisted of rats that received the rectal application of saline alone; Group IPDex (n=8) included rats that received the intraperitoneal application of dexmedetomidine (100 mu g kg(-1)); and Group RecDex (n=8) included rats that received the rectal application of dexmedetomidine (100 mu g kg(-1)). For the rectal drug administration, we used 22 G intravenous cannulas with the stylets removed. We administered the drugs by advancing the cannula 1 cm into the rectum, and the rectal administration volume was 1 mL for all the rats. The latency and anesthesia time (min) were measured. Two hours after rectal administration, 75 mg kg(-1) ketamine was administered for intraperitoneal anesthesia in all the groups, followed by the removal of the rats' rectums to a distal distance of 3 cm via an abdominoperineal surgical procedure. We histopathologically examined and scored the rectums. Results: Anesthesia was achieved in all the rats in the Group RecDex following the administration of dexmedetomidine. The onset of anesthesia in the Group RecDex was significantly later and of a shorter duration than in the Group IPDEx (p<0.05). In the Group RecDex, the administration of dexmedetomidine induced mild-moderate losses of mucosal architecture in the colon and rectum, 2h after rectal inoculation. Conclusion: Although 100 mu g kg(-1) dexnnedetomidine administered rectally to rats achieved a significantly longer duration of anesthesia compared with the rectal administration of saline, our histopathological evaluations showed that the rectal administration of 100 mu g kg(-1) dexmedetomidine led to mild-moderate damage to the mucosal structure of the rectum. (C) 2013 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.

Yazar Hanci, Volkan
Gulle, Kanat
Karakaya, Kemal
Yurtlu, Serhan
Akpolat, Meryem
Yuce, Mehmet Fatih
Yuce, Fatma Zehra
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3232
Tek Biçim Adres 10.1016/j.bjane.2013.09.005
Konu Başlıkları Dexmedetomidine
Rectum
Rat
Anesthesia
Mucosa
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı REVISTA BRASILEIRA DE ANESTESIOLOGIA
Dergi Cilt Bilgisi 65
Dergi Sayısı 1
Sayfalar 1 - 6
Yayın Yılı 2015
Eser Adı
[dc.title]
Rectal dexmedetomidine in rats: evaluation of sedative and mucosal effects
Yazar
[dc.contributor.author]
Hanci, Volkan
Yazar
[dc.contributor.author]
Gulle, Kanat
Yazar
[dc.contributor.author]
Karakaya, Kemal
Yazar
[dc.contributor.author]
Yurtlu, Serhan
Yazar
[dc.contributor.author]
Akpolat, Meryem
Yazar
[dc.contributor.author]
Yuce, Mehmet Fatih
Yazar
[dc.contributor.author]
Yuce, Fatma Zehra
Yayın Yılı
[dc.date.issued]
2015
Yayıncı
[dc.publisher]
ELSEVIER SCIENCE INC
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background and objectives: In this study, we investigated the anesthetic and mucosal effects of the rectal application of dexmedetomidine to rats. Methods: Male Wistar albino rats weighing 250-300 g were divided into four groups: Group S (n=8) was a sham group that served as a baseline for the normal basal values; Group C (n=8) consisted of rats that received the rectal application of saline alone; Group IPDex (n=8) included rats that received the intraperitoneal application of dexmedetomidine (100 mu g kg(-1)); and Group RecDex (n=8) included rats that received the rectal application of dexmedetomidine (100 mu g kg(-1)). For the rectal drug administration, we used 22 G intravenous cannulas with the stylets removed. We administered the drugs by advancing the cannula 1 cm into the rectum, and the rectal administration volume was 1 mL for all the rats. The latency and anesthesia time (min) were measured. Two hours after rectal administration, 75 mg kg(-1) ketamine was administered for intraperitoneal anesthesia in all the groups, followed by the removal of the rats' rectums to a distal distance of 3 cm via an abdominoperineal surgical procedure. We histopathologically examined and scored the rectums. Results: Anesthesia was achieved in all the rats in the Group RecDex following the administration of dexmedetomidine. The onset of anesthesia in the Group RecDex was significantly later and of a shorter duration than in the Group IPDEx (p<0.05). In the Group RecDex, the administration of dexmedetomidine induced mild-moderate losses of mucosal architecture in the colon and rectum, 2h after rectal inoculation. Conclusion: Although 100 mu g kg(-1) dexnnedetomidine administered rectally to rats achieved a significantly longer duration of anesthesia compared with the rectal administration of saline, our histopathological evaluations showed that the rectal administration of 100 mu g kg(-1) dexmedetomidine led to mild-moderate damage to the mucosal structure of the rectum. (C) 2013 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.
Açıklama
[dc.description]
WOS: 000348246300001
Açıklama
[dc.description]
PubMed: 25497742
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Dexmedetomidine
Konu Başlıkları
[dc.subject]
Rectum
Konu Başlıkları
[dc.subject]
Rat
Konu Başlıkları
[dc.subject]
Anesthesia
Konu Başlıkları
[dc.subject]
Mucosa
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0034-7094
ISSN
[dc.identifier.issn]
1806-907X
İlk Sayfa Sayısı
[dc.identifier.startpage]
1
Son Sayfa Sayısı
[dc.identifier.endpage]
6
Dergi Adı
[dc.relation.journal]
REVISTA BRASILEIRA DE ANESTESIOLOGIA
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
65
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.bjane.2013.09.005
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3232
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
25
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 06:02
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Tıklayınız
rectal administration dexmedetomidine application RecDex anesthesia rectum administered kg(-1) mucosal received saline duration significantly groups kg(-1)) included achieved rectums mild-moderate intraperitoneal Background shorter following Anesthesia Results scored examined histopathologically procedure surgical Although induced damage reserved
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