Possible effect of gene polymorphisms on the release of TNF alpha and IL1 cytokines in coal workers' pneumoconiosis

It has been shown that coal dust exposure stimulates inflammatory response leading to increased release of cytokines from monocytes such as TNF-alpha and IL1 These released cytokines play the key role in the pathogenesis of pneumoconiosis including coal workers' pneumoconiosis. In this study, we investigated TNFA, IL1A, IL1B and IL1RA genes variations on basal, lipopolysaccharide and coal dust-induced cytokine release from blood monocytes of homozygous allele and minor variant allele carriers in Turkish coal workers and CWP patients. According to the genotyping results, TNFA -238 gene polymorphism was found as a risk factor in CWP development (OR=3.79) and to in vitro results; release of both TNF-alpha and IL1 cytokines from the monocytes in CWP patients was significantly increased compared to the healthy workers. Also. LPS and coal dust stimulated release of TNF-alpha, which was significantly higher in allele 2 carriers compared to subjects carrying allele 1 in both the groups. These data suggest that the coal dust-induced release of TNF-alpha from monocytes may be a useful biomarker of CWP. (C) 2009 Elsevier GmbH. All rights reserved.

Yazar Ates, Ilker
Yucesoy, Berran
Yucel, Aysegul
Suzen, Sinan H.
Karakas, Yalcin
Karakaya, Asuman
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3114
Tek Biçim Adres 10.1016/j.etp.2009.11.006
Konu Başlıkları Coal workers' pneumoconiosis
TNFA
IL1
Genotype
Phenotype
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
Dergi Cilt Bilgisi 63
Dergi Sayısı 01.Feb
Sayfalar 175 - 179
Yayın Yılı 2011
Eser Adı
[dc.title]
Possible effect of gene polymorphisms on the release of TNF alpha and IL1 cytokines in coal workers' pneumoconiosis
Yazar
[dc.contributor.author]
Ates, Ilker
Yazar
[dc.contributor.author]
Yucesoy, Berran
Yazar
[dc.contributor.author]
Yucel, Aysegul
Yazar
[dc.contributor.author]
Suzen, Sinan H.
Yazar
[dc.contributor.author]
Karakas, Yalcin
Yazar
[dc.contributor.author]
Karakaya, Asuman
Yayın Yılı
[dc.date.issued]
2011
Yayıncı
[dc.publisher]
ELSEVIER GMBH, URBAN & FISCHER VERLAG
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
It has been shown that coal dust exposure stimulates inflammatory response leading to increased release of cytokines from monocytes such as TNF-alpha and IL1 These released cytokines play the key role in the pathogenesis of pneumoconiosis including coal workers' pneumoconiosis. In this study, we investigated TNFA, IL1A, IL1B and IL1RA genes variations on basal, lipopolysaccharide and coal dust-induced cytokine release from blood monocytes of homozygous allele and minor variant allele carriers in Turkish coal workers and CWP patients. According to the genotyping results, TNFA -238 gene polymorphism was found as a risk factor in CWP development (OR=3.79) and to in vitro results; release of both TNF-alpha and IL1 cytokines from the monocytes in CWP patients was significantly increased compared to the healthy workers. Also. LPS and coal dust stimulated release of TNF-alpha, which was significantly higher in allele 2 carriers compared to subjects carrying allele 1 in both the groups. These data suggest that the coal dust-induced release of TNF-alpha from monocytes may be a useful biomarker of CWP. (C) 2009 Elsevier GmbH. All rights reserved.
Açıklama
[dc.description]
WOS: 000286779300025
Açıklama
[dc.description]
PubMed: 20005085
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Coal workers' pneumoconiosis
Konu Başlıkları
[dc.subject]
TNFA
Konu Başlıkları
[dc.subject]
IL1
Konu Başlıkları
[dc.subject]
Genotype
Konu Başlıkları
[dc.subject]
Phenotype
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0940-2993
Sponsor YAYINCI
[dc.description.sponsorship]
Ankara UniversityAnkara University [20030803036]
Sponsor YAYINCI
[dc.description.sponsorship]
This study was supported by Research Fund of Ankara University (20030803036).
İlk Sayfa Sayısı
[dc.identifier.startpage]
175
Son Sayfa Sayısı
[dc.identifier.endpage]
179
Dergi Adı
[dc.relation.journal]
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
Dergi Sayısı
[dc.identifier.issue]
01.Feb
Dergi Cilt Bilgisi
[dc.identifier.volume]
63
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.etp.2009.11.006
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3114
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Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
5
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
18 Ocak 2024 16:56
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Tıklayınız
release allele TNF-alpha monocytes workers cytokines patients dust-induced compared carriers significantly results pneumoconiosis increased Elsevier development factor rights reserved healthy carrying suggest polymorphism groups subjects useful higher biomarker stimulated released including pathogenesis leading response inflammatory
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