Protection of endotoxin-incluced oxidative renal tissue damage of rats by vitamin E or/and EGb 761 treatment

The aim of the present study was to evaluate the possible protective effects of vitamin E and EGb 761 treatments, alone or in combination, against oxidative renal tissue damage in experimentally induced endotoxaemic rats. Fifty healthy male Wistar albino rats, weighing 150-250 g and averaging 12 weeks old, were allotted randomly into one of five experimental groups: A (untreated), B (endotoxaemic), C (endotoxaemic + vitamin E treated), D (endotoaxemic + EGb 761 treated) and E (endotoxaemic + vitamin E and EGb 761 treated), each containing ten animals. Group A received only an intraperitoneal (i.p.) injection of 2 ml of normal saline solution and served as the control. Groups B, C, D and E were administrated a single i.p. injection of 0.5 ml of endotoxin solution. In addition, groups C, D and E received i.p. injections of 600 mg kg(-1) body mt. of vitamin E and oral extract of 50 mg kg(-1) body wt. of EGb 761, alone or in combination, immediately after the endotoxin injection. The experiment lasted for 24 h. At the end of the experiment blood and tissue samples were obtained for biochemical and histopathological investigation. Endotoxin injection produced renal damage, increased lipid peroxidation and decreased antioxidant enzyme activity. Vitamin E or/and EGb 761 treatment decreased lipid peroxidation, increased antioxidant enzyme activity and also prevented renal tissue damage in experimentally induced endotoxaemic rats. In conclusion, vitamin E and EGb 761 treatment, alone or in combination, appears to be beneficial in preventing endotoxin-induced oxidative renal tissue damage and therefore shows potential for clinical use. Copyright (C) 2005 John Wiley Sons, Ltd.

Yazar Coskun, O
Armutcu, F
Kanter, M
Kuzey, GM
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3181
Tek Biçim Adres 10.1002/jat.1002
Konu Başlıkları endotoxaemia
vitamin E
EGb 761
lipid peroxidation
kidney
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı JOURNAL OF APPLIED TOXICOLOGY
Dergi Cilt Bilgisi 25
Dergi Sayısı 1
Sayfalar 8 - 12
Yayın Yılı 2005
Eser Adı
[dc.title]
Protection of endotoxin-incluced oxidative renal tissue damage of rats by vitamin E or/and EGb 761 treatment
Yazar
[dc.contributor.author]
Coskun, O
Yazar
[dc.contributor.author]
Armutcu, F
Yazar
[dc.contributor.author]
Kanter, M
Yazar
[dc.contributor.author]
Kuzey, GM
Yayın Yılı
[dc.date.issued]
2005
Yayıncı
[dc.publisher]
WILEY-BLACKWELL
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
The aim of the present study was to evaluate the possible protective effects of vitamin E and EGb 761 treatments, alone or in combination, against oxidative renal tissue damage in experimentally induced endotoxaemic rats. Fifty healthy male Wistar albino rats, weighing 150-250 g and averaging 12 weeks old, were allotted randomly into one of five experimental groups: A (untreated), B (endotoxaemic), C (endotoxaemic + vitamin E treated), D (endotoaxemic + EGb 761 treated) and E (endotoxaemic + vitamin E and EGb 761 treated), each containing ten animals. Group A received only an intraperitoneal (i.p.) injection of 2 ml of normal saline solution and served as the control. Groups B, C, D and E were administrated a single i.p. injection of 0.5 ml of endotoxin solution. In addition, groups C, D and E received i.p. injections of 600 mg kg(-1) body mt. of vitamin E and oral extract of 50 mg kg(-1) body wt. of EGb 761, alone or in combination, immediately after the endotoxin injection. The experiment lasted for 24 h. At the end of the experiment blood and tissue samples were obtained for biochemical and histopathological investigation. Endotoxin injection produced renal damage, increased lipid peroxidation and decreased antioxidant enzyme activity. Vitamin E or/and EGb 761 treatment decreased lipid peroxidation, increased antioxidant enzyme activity and also prevented renal tissue damage in experimentally induced endotoxaemic rats. In conclusion, vitamin E and EGb 761 treatment, alone or in combination, appears to be beneficial in preventing endotoxin-induced oxidative renal tissue damage and therefore shows potential for clinical use. Copyright (C) 2005 John Wiley Sons, Ltd.
Açıklama
[dc.description]
WOS: 000226733600002
Açıklama
[dc.description]
PubMed: 15669049
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
endotoxaemia
Konu Başlıkları
[dc.subject]
vitamin E
Konu Başlıkları
[dc.subject]
EGb 761
Konu Başlıkları
[dc.subject]
lipid peroxidation
Konu Başlıkları
[dc.subject]
kidney
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0260-437X
ISSN
[dc.identifier.issn]
1099-1263
İlk Sayfa Sayısı
[dc.identifier.startpage]
8
Son Sayfa Sayısı
[dc.identifier.endpage]
12
Dergi Adı
[dc.relation.journal]
JOURNAL OF APPLIED TOXICOLOGY
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
25
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1002/jat.1002
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3181
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215
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1
09.12.2022 tarihinden bu yana
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17 Temmuz 2024 02:37
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Tıklayınız
vitamin damage tissue injection treated) combination peroxidation groups decreased antioxidant enzyme (endotoxaemic increased received solution experiment endotoxin activity kg(-1) endotoxaemic treatment oxidative experimentally induced Copyright lasted immediately extract or/and clinical therefore prevented conclusion appears beneficial
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