Identification of Patients with Microscopic Hematuria who are at Greater Risk for the Presence of Bladder Tumors Using a Dedicated Questionnaire and Point of Care Urine Test - A Study by the Members of Association of Urooncology, Turkey

In patients with microscopic hematuria there is a need for better identification of those who are at greater risk of harbouring bladder tumors. The RisikoCheck (c) questionnaire has a strong correlation with the presence of urothelial carcinoma (UC) of the bladder and in combination with other available tests may help identify patients who require detailed clinical investigations due to increased risk of presence of bladder tumors. This study aimed to evaluate the efficacy of RisikoCheck (c) questionnaire together with NMP-22 (R) (BladderChek (R)) as a point-of-care urine test in predicting the presence of bladder tumors in patients presenting with microscopic hematuria as the sole finding. In this multi-institutional prospective evaluation of 303 consecutive patients without a history of urothelial carcinoma (UC), RisikoCheck (c) risk group assessment, urinary tract imaging and cystourethroscopy as well as urine cytology and Nuclear Matrix Protein-22 (NMP-22 BladderChek) testing were performed where available. The sensitivity, specificity, negative predictive value (NPV), and positive predictive values (PPV) for the risk adapted approach were calculated. All patients underwent cystoscopy, and tumors were detected in 18 (5.9%). Urine cytology and NMP-22 was positive for malignancy in 9 (3.2%) and 12 (7.5%) of patients, respectively. A total of 43 (14%) patients were in the high risk group according to the RisikoCheck (c) questionnaire. The sensitivity and specificity of the questionnaire in detecting a bladder tumor was 61.5 % and 84.0 % in the high risk group. In patients with either a positive NMP-22 test or high risk category RisikoCheck (c), 23.6% had bladder tumors with a corresponding sensitivity of 54.2% and specificity of 88.6%. If both tests were negative only 3.3% of the patients had bladder tumors. The results of our study suggest that the efficacy of diagnostic evaluation of patients with microscopic hematuria may be further enhanced by combining RisikoCheck (c) questionnaire with NMP-22.

Yazar Turkeri, Levent
Mangir, Naside
Gunlusoy, Bulent
Yildirim, Asif
Baltaci, Sumer
Kaplan, Mustafa
Bozlu, Murat
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2739
Tek Biçim Adres 10.7314/APJCP.2014.15.15.6283
Konu Başlıkları Microscopic hematuria
bladder neoplasms
RisikoCheck (c)
NMP-22
bladder check
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
Dergi Cilt Bilgisi 15
Dergi Sayısı 15
Sayfalar 6283 - 6286
Yayın Yılı 2014
Eser Adı
[dc.title]
Identification of Patients with Microscopic Hematuria who are at Greater Risk for the Presence of Bladder Tumors Using a Dedicated Questionnaire and Point of Care Urine Test - A Study by the Members of Association of Urooncology, Turkey
Yazar
[dc.contributor.author]
Turkeri, Levent
Yazar
[dc.contributor.author]
Mangir, Naside
Yazar
[dc.contributor.author]
Gunlusoy, Bulent
Yazar
[dc.contributor.author]
Yildirim, Asif
Yazar
[dc.contributor.author]
Baltaci, Sumer
Yazar
[dc.contributor.author]
Kaplan, Mustafa
Yazar
[dc.contributor.author]
Bozlu, Murat
Yayın Yılı
[dc.date.issued]
2014
Yayıncı
[dc.publisher]
ASIAN PACIFIC ORGANIZATION CANCER PREVENTION
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
In patients with microscopic hematuria there is a need for better identification of those who are at greater risk of harbouring bladder tumors. The RisikoCheck (c) questionnaire has a strong correlation with the presence of urothelial carcinoma (UC) of the bladder and in combination with other available tests may help identify patients who require detailed clinical investigations due to increased risk of presence of bladder tumors. This study aimed to evaluate the efficacy of RisikoCheck (c) questionnaire together with NMP-22 (R) (BladderChek (R)) as a point-of-care urine test in predicting the presence of bladder tumors in patients presenting with microscopic hematuria as the sole finding. In this multi-institutional prospective evaluation of 303 consecutive patients without a history of urothelial carcinoma (UC), RisikoCheck (c) risk group assessment, urinary tract imaging and cystourethroscopy as well as urine cytology and Nuclear Matrix Protein-22 (NMP-22 BladderChek) testing were performed where available. The sensitivity, specificity, negative predictive value (NPV), and positive predictive values (PPV) for the risk adapted approach were calculated. All patients underwent cystoscopy, and tumors were detected in 18 (5.9%). Urine cytology and NMP-22 was positive for malignancy in 9 (3.2%) and 12 (7.5%) of patients, respectively. A total of 43 (14%) patients were in the high risk group according to the RisikoCheck (c) questionnaire. The sensitivity and specificity of the questionnaire in detecting a bladder tumor was 61.5 % and 84.0 % in the high risk group. In patients with either a positive NMP-22 test or high risk category RisikoCheck (c), 23.6% had bladder tumors with a corresponding sensitivity of 54.2% and specificity of 88.6%. If both tests were negative only 3.3% of the patients had bladder tumors. The results of our study suggest that the efficacy of diagnostic evaluation of patients with microscopic hematuria may be further enhanced by combining RisikoCheck (c) questionnaire with NMP-22.
Açıklama
[dc.description]
WOS: 000343723600055
Açıklama
[dc.description]
PubMed: 25124612
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Microscopic hematuria
Konu Başlıkları
[dc.subject]
bladder neoplasms
Konu Başlıkları
[dc.subject]
RisikoCheck (c)
Konu Başlıkları
[dc.subject]
NMP-22
Konu Başlıkları
[dc.subject]
bladder check
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1513-7368
İlk Sayfa Sayısı
[dc.identifier.startpage]
6283
Son Sayfa Sayısı
[dc.identifier.endpage]
6286
Dergi Adı
[dc.relation.journal]
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
Dergi Sayısı
[dc.identifier.issue]
15
Dergi Cilt Bilgisi
[dc.identifier.volume]
15
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.7314/APJCP.2014.15.15.6283
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2739
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
20
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
04 Şubat 2024 20:51
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Tıklayınız
patients bladder tumors RisikoCheck questionnaire NMP-22 presence sensitivity specificity positive microscopic hematuria efficacy cytology evaluation predictive available urothelial carcinoma negative respectively approach calculated enhanced underwent malignancy combining cystoscopy detected results diagnostic suggest corresponding adapted either
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