Relationship between Uric Acid and Subtle Cognitive Dysfunction in Chronic Kidney Disease

Background: Elevated serum uric acid has been associated with cognitive dysfunction and vascular cognitive impairment in the elderly. Serum uric acid is also commonly elevated in chronic kidney disease (CKD), but its relationship with cognitive function in these patients has not been addressed. Methods: Subjects with CKD (defined as eGFR <60/ml/min/1.73 m(2)) were evaluated for cognitive dysfunction using the validated Standardized Mini-Mental State Examination (SMMSE). Individuals with dementia, depression or other psychiatric disorders were excluded, as were subjects on uric acid-lowering therapy or with serious illnesses such as severe anemia or active or ongoing cardiovascular or cerebrovascular disease. Results: 247 subjects were enrolled. SMMSE scores showed stepwise deterioration with increasing quartile of serum uric acid (26.4; 26.1; 25.5; 25.3, score range 20-30, p = 0.019). Post-hoc analysis demonstrated that there was no linear trend and only groups 1 and 4 were different with respect to SMMSE scores (p = 0.025). Stepwise multivariate linear regression revealed that age, educational status, presence of cerebrovascular disease, and serum uric acid were independently related to SMMSE scores. Conclusion: Serum uric acid levels are independently and inversely associated with mild cognitive dysfunction in subjects with CKD. Copyright (C) 2011 S. Karger AG, Basel

Yazar Afsar, Baris
Elsurer, Rengin
Covic, Adrian
Johnson, Richard J.
Kanbay, Mehmet
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3246
Tek Biçim Adres 10.1159/000329097
Konu Başlıkları Cognitive function
Chronic kidney disease
Uric acid
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı AMERICAN JOURNAL OF NEPHROLOGY
Dergi Cilt Bilgisi 34
Dergi Sayısı 1
Sayfalar 49 - 54
Yayın Yılı 2011
Eser Adı
[dc.title]
Relationship between Uric Acid and Subtle Cognitive Dysfunction in Chronic Kidney Disease
Yazar
[dc.contributor.author]
Afsar, Baris
Yazar
[dc.contributor.author]
Elsurer, Rengin
Yazar
[dc.contributor.author]
Covic, Adrian
Yazar
[dc.contributor.author]
Johnson, Richard J.
Yazar
[dc.contributor.author]
Kanbay, Mehmet
Yayın Yılı
[dc.date.issued]
2011
Yayıncı
[dc.publisher]
KARGER
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background: Elevated serum uric acid has been associated with cognitive dysfunction and vascular cognitive impairment in the elderly. Serum uric acid is also commonly elevated in chronic kidney disease (CKD), but its relationship with cognitive function in these patients has not been addressed. Methods: Subjects with CKD (defined as eGFR <60/ml/min/1.73 m(2)) were evaluated for cognitive dysfunction using the validated Standardized Mini-Mental State Examination (SMMSE). Individuals with dementia, depression or other psychiatric disorders were excluded, as were subjects on uric acid-lowering therapy or with serious illnesses such as severe anemia or active or ongoing cardiovascular or cerebrovascular disease. Results: 247 subjects were enrolled. SMMSE scores showed stepwise deterioration with increasing quartile of serum uric acid (26.4; 26.1; 25.5; 25.3, score range 20-30, p = 0.019). Post-hoc analysis demonstrated that there was no linear trend and only groups 1 and 4 were different with respect to SMMSE scores (p = 0.025). Stepwise multivariate linear regression revealed that age, educational status, presence of cerebrovascular disease, and serum uric acid were independently related to SMMSE scores. Conclusion: Serum uric acid levels are independently and inversely associated with mild cognitive dysfunction in subjects with CKD. Copyright (C) 2011 S. Karger AG, Basel
Açıklama
[dc.description]
WOS: 000291756100007
Açıklama
[dc.description]
PubMed: 21659739
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Cognitive function
Konu Başlıkları
[dc.subject]
Chronic kidney disease
Konu Başlıkları
[dc.subject]
Uric acid
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0250-8095
ISSN
[dc.identifier.issn]
1421-9670
Sponsor YAYINCI
[dc.description.sponsorship]
NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [HL-68607]
Sponsor YAYINCI
[dc.description.sponsorship]
Support for this paper was provided in part by NIH grant HL-68607.
İlk Sayfa Sayısı
[dc.identifier.startpage]
49
Son Sayfa Sayısı
[dc.identifier.endpage]
54
Dergi Adı
[dc.relation.journal]
AMERICAN JOURNAL OF NEPHROLOGY
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
34
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1159/000329097
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3246
Görüntülenme Sayısı ( Şehir )
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Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
16
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
13 Şubat 2024 22:50
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cognitive subjects disease scores dysfunction linear independently associated cerebrovascular analysis demonstrated Post-hoc deterioration increasing quartile Background presence Karger Copyright inversely levels Conclusion related status educational revealed regression multivariate Stepwise stepwise respect different groups severe showed
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