The relationship of age-adjusted Charlson comorbidity index and diurnal variation of blood pressure

Backgrounds: Charlson Comorbidity index (CCI) is a scoring system to predict prognosis and mortality. It exhibits better utility when combined with age, age-adjusted Charlson Comorbidity Index (ACCI). The aim of this study was to evaluate the relationship between ACCI and diurnal variation of blood pressure parameters in hypertensive patients and normotensive patients. Methods: We enrolled 236 patients. All patients underwent a 24-h ambulatory blood pressure monitoring (ABPM) for evaluation of dipper or non-dipper pattern. We searched the correlation between ACCI and dipper or non-dipper pattern and other ABPM parameters. To further investigate the role of these parameters in predicting survival, a multivariate analysis using the Cox proportional hazard model was performed. Results: 167 patients were in the hypertensive group (87 patients in non-dipper status) and 69 patients were in the normotensive group (41 patients in non-dipper status) of all study patients. We found a significant difference and negative correlation between AACI and 24-h diastolic blood pressure (DBP), awake DBP, awake mean blood pressure (MBP) and 24-h MBP and awake systolic blood pressure(SBP). Night decrease ratio of blood pressure had also a negative correlation with ACCI (p = 0.003, r = -0.233). However, we found a relationship with non-dipper pattern and ACCI in the hypertensive patients (p = 0.050). In multivariate Cox analysis sleep MBP was found related to mortality like ACCI (p = 0.023, HR = 1.086, %95 CI 1.012-1.165) Conclusion: ACCI was statistically significantly higher in non-dipper hypertensive patients than dipper hypertensive patients while ACCI had a negative correlation with blood pressure. Sleep MBP may predict mortality.

Dergi Adı CLINICAL AND EXPERIMENTAL HYPERTENSION
Dergi Cilt Bilgisi 41
Dergi Sayısı 2
Sayfalar 113 - 117
Yayın Yılı 2019
Eser Adı
[dc.title]
The relationship of age-adjusted Charlson comorbidity index and diurnal variation of blood pressure
Yazar
[dc.contributor.author]
Kalayci, Belma
Yazar
[dc.contributor.author]
Erten, Yunus Turgay
Yazar
[dc.contributor.author]
Akgun, Tunahan
Yazar
[dc.contributor.author]
Karabag, Turgut
Yazar
[dc.contributor.author]
Kokturk, Furuzan
Yayın Yılı
[dc.date.issued]
2019
Yayıncı
[dc.publisher]
TAYLOR & FRANCIS INC
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Backgrounds: Charlson Comorbidity index (CCI) is a scoring system to predict prognosis and mortality. It exhibits better utility when combined with age, age-adjusted Charlson Comorbidity Index (ACCI). The aim of this study was to evaluate the relationship between ACCI and diurnal variation of blood pressure parameters in hypertensive patients and normotensive patients. Methods: We enrolled 236 patients. All patients underwent a 24-h ambulatory blood pressure monitoring (ABPM) for evaluation of dipper or non-dipper pattern. We searched the correlation between ACCI and dipper or non-dipper pattern and other ABPM parameters. To further investigate the role of these parameters in predicting survival, a multivariate analysis using the Cox proportional hazard model was performed. Results: 167 patients were in the hypertensive group (87 patients in non-dipper status) and 69 patients were in the normotensive group (41 patients in non-dipper status) of all study patients. We found a significant difference and negative correlation between AACI and 24-h diastolic blood pressure (DBP), awake DBP, awake mean blood pressure (MBP) and 24-h MBP and awake systolic blood pressure(SBP). Night decrease ratio of blood pressure had also a negative correlation with ACCI (p = 0.003, r = -0.233). However, we found a relationship with non-dipper pattern and ACCI in the hypertensive patients (p = 0.050). In multivariate Cox analysis sleep MBP was found related to mortality like ACCI (p = 0.023, HR = 1.086, %95 CI 1.012-1.165) Conclusion: ACCI was statistically significantly higher in non-dipper hypertensive patients than dipper hypertensive patients while ACCI had a negative correlation with blood pressure. Sleep MBP may predict mortality.
Açıklama
[dc.description]
WOS: 000454914000002
Açıklama
[dc.description]
PubMed: 29504835
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Age-adjusted Charlson comorbidity index
Konu Başlıkları
[dc.subject]
ambulatory blood pressure monitoring
Konu Başlıkları
[dc.subject]
charlson comorbidity index
Konu Başlıkları
[dc.subject]
dipper hypertension
Konu Başlıkları
[dc.subject]
non-dipper hypertension
Konu Başlıkları
[dc.subject]
hypertension
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1064-1963
ISSN
[dc.identifier.issn]
1525-6006
İlk Sayfa Sayısı
[dc.identifier.startpage]
113
Son Sayfa Sayısı
[dc.identifier.endpage]
117
Dergi Adı
[dc.relation.journal]
CLINICAL AND EXPERIMENTAL HYPERTENSION
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
41
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1080/10641963.2018.1445755
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3651
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
255
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
17 Temmuz 2024 17:46
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Tıklayınız
patients pressure non-dipper hypertensive correlation parameters mortality between dipper pattern negative multivariate normotensive analysis status) relationship Charlson Comorbidity predict higher systolic statistically significantly diastolic difference significant pressure(SBP) Conclusion decrease However related Backgrounds combined variation diurnal
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