Association of left ventricular diastolic dysfunction with elevated NT-proBNP in type 2 diabetes mellitus patients with preserved ejection fraction: The supplemantary role of tissue doppler imaging parameters and NT-proBNP levels

Background: Early diagnosis of cardiovascular disease in diabetic patients may be important to introduce treatment early. Echocardiography is a method used to show the ventricular functions. A ventricular hormone, BNP is used to identify the changes in the ventricular function in early period. NT-proBNP which is a more stable compound with a longer half-life is used in measurement of BNP. Methods: Left ventricular diastolic dysfunction (LVDD) was detected and NT-proBNP levels were measured in forty-four asymptomatic patients with ages of 30-70 and type 2 DM and control group consisted of 40 healthy individuals from the same age group. Results: NT-proBNP levels were found as 566.7 +/- 738.5 pg/ml in the diabetics with LVDD detected, 166.3 +/- 137.1 pg/ml in the diabetics without LVDD and 134.5 +/- 77.2 pg/ml in the control group. Levels of NT-proBNP were significantly higher in the group with left ventricular diastolic dysfunction (p < 0.05). However, when the levels of NT-proBNP in the diabetic patients without LVDD were compared with the controls, the difference was not significant (p > 0.05). NT-proBNP levels were found significantly higher in LVDD group compared to the controls without a difference between the ejection fractions (p < 0.05). Conclusion: High levels of NT-proBNP was correlated tissue Doppler echocardiography findings in type 2 DM patients with preserved ejection fraction. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

Yazar Ciftel, Sedat
Icagasioglu, Serhat
Yildiz, Gursel
Tekin, Gonca
Aydin, Huseyin
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2130
Tek Biçim Adres 10.1016/j.diabres.2011.12.021
Konu Başlıkları Left ventricular diastolic
dysfunction
NT-proBNP
Tissue Doppler echocardiography
Type 2 diabetes mellitus
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı DIABETES RESEARCH AND CLINICAL PRACTICE
Dergi Cilt Bilgisi 96
Dergi Sayısı 2
Sayfalar 179 - 186
Yayın Yılı 2012
Eser Adı
[dc.title]
Association of left ventricular diastolic dysfunction with elevated NT-proBNP in type 2 diabetes mellitus patients with preserved ejection fraction: The supplemantary role of tissue doppler imaging parameters and NT-proBNP levels
Yazar
[dc.contributor.author]
Ciftel, Sedat
Yazar
[dc.contributor.author]
Icagasioglu, Serhat
Yazar
[dc.contributor.author]
Yildiz, Gursel
Yazar
[dc.contributor.author]
Tekin, Gonca
Yazar
[dc.contributor.author]
Aydin, Huseyin
Yayın Yılı
[dc.date.issued]
2012
Yayıncı
[dc.publisher]
ELSEVIER IRELAND LTD
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background: Early diagnosis of cardiovascular disease in diabetic patients may be important to introduce treatment early. Echocardiography is a method used to show the ventricular functions. A ventricular hormone, BNP is used to identify the changes in the ventricular function in early period. NT-proBNP which is a more stable compound with a longer half-life is used in measurement of BNP. Methods: Left ventricular diastolic dysfunction (LVDD) was detected and NT-proBNP levels were measured in forty-four asymptomatic patients with ages of 30-70 and type 2 DM and control group consisted of 40 healthy individuals from the same age group. Results: NT-proBNP levels were found as 566.7 +/- 738.5 pg/ml in the diabetics with LVDD detected, 166.3 +/- 137.1 pg/ml in the diabetics without LVDD and 134.5 +/- 77.2 pg/ml in the control group. Levels of NT-proBNP were significantly higher in the group with left ventricular diastolic dysfunction (p < 0.05). However, when the levels of NT-proBNP in the diabetic patients without LVDD were compared with the controls, the difference was not significant (p > 0.05). NT-proBNP levels were found significantly higher in LVDD group compared to the controls without a difference between the ejection fractions (p < 0.05). Conclusion: High levels of NT-proBNP was correlated tissue Doppler echocardiography findings in type 2 DM patients with preserved ejection fraction. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
Açıklama
[dc.description]
WOS: 000303668000023
Açıklama
[dc.description]
PubMed: 22240157
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Left ventricular diastolic
Konu Başlıkları
[dc.subject]
dysfunction
Konu Başlıkları
[dc.subject]
NT-proBNP
Konu Başlıkları
[dc.subject]
Tissue Doppler echocardiography
Konu Başlıkları
[dc.subject]
Type 2 diabetes mellitus
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0168-8227
ISSN
[dc.identifier.issn]
1872-8227
İlk Sayfa Sayısı
[dc.identifier.startpage]
179
Son Sayfa Sayısı
[dc.identifier.endpage]
186
Dergi Adı
[dc.relation.journal]
DIABETES RESEARCH AND CLINICAL PRACTICE
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
96
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.diabres.2011.12.021
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2130
Görüntülenme Sayısı ( Şehir )
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Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
42
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İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
07 Şubat 2024 21:50
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NT-proBNP levels ventricular patients without compared diastolic dysfunction diabetics detected control higher significantly controls difference ejection diabetic reserved rights significant Levels Ireland Elsevier between fraction preserved findings echocardiography Doppler tissue correlated Conclusion fractions However Background
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