A comparative tool for the validity of rate kinetics in ion channels by Onsager reciprocity theorem

The precise form of the rate constant functions of ion channels is very crucial for reproducing the electrophysiological behavior. Therefore, how well they account for experimental data plays an important role in the behavior of the model. In this study, we derive kinetic coefficients of activation and inactivation gates in ion channels by Onsager reciprocity theorem for an ensemble of gating particles, and propose that the obtained kinetic coefficients can be used as a comparative tool for the empirical validity of fitted rate constant functions to experimental data. We also illustrate its applicability based on the activation and inactivation kinetics of T-type calcium channel in thalamic relay neurons. We show that the shape of the steady-state curve by itself seems to be a poor indicator of the functional form of the rate functions, but the time constant curves reflect considerable variation depending on the particular form of the rate functions, and that the kinetic coefficients related to the time constants provide a powerful tool to determine the empirical validity of the fitted rate constants. (C) 2004 Elsevier Ltd. All rights reserved.

Eser Adı
[dc.title]
A comparative tool for the validity of rate kinetics in ion channels by Onsager reciprocity theorem
Yazar
[dc.contributor.author]
Özer, Mahmut
Yazar
[dc.contributor.author]
Provaznik, Ivo
Yayın Yılı
[dc.date.issued]
2005
Yayıncı
[dc.publisher]
ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
The precise form of the rate constant functions of ion channels is very crucial for reproducing the electrophysiological behavior. Therefore, how well they account for experimental data plays an important role in the behavior of the model. In this study, we derive kinetic coefficients of activation and inactivation gates in ion channels by Onsager reciprocity theorem for an ensemble of gating particles, and propose that the obtained kinetic coefficients can be used as a comparative tool for the empirical validity of fitted rate constant functions to experimental data. We also illustrate its applicability based on the activation and inactivation kinetics of T-type calcium channel in thalamic relay neurons. We show that the shape of the steady-state curve by itself seems to be a poor indicator of the functional form of the rate functions, but the time constant curves reflect considerable variation depending on the particular form of the rate functions, and that the kinetic coefficients related to the time constants provide a powerful tool to determine the empirical validity of the fitted rate constants. (C) 2004 Elsevier Ltd. All rights reserved.
Açıklama
[dc.description]
WOS: 000226462300007
Açıklama
[dc.description]
PubMed: 15619363
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
kinetic coefficient
Konu Başlıkları
[dc.subject]
ion channel
Konu Başlıkları
[dc.subject]
rate kinetics
Konu Başlıkları
[dc.subject]
Onsager reciprocity theorem
Künye
[dc.identifier.citation]
Ozer, M. ve Provaznik, I. (2005). A comparative tool for the validity of rate kinetics in ion channels by Onsager reciprocity theorem. Journal of Theoretical Biology, 233(2), 237–243. doi:https://doi.org/10.1016/j.jtbi.2004.10.005
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0022-5193
İlk Sayfa Sayısı
[dc.identifier.startpage]
237
Son Sayfa Sayısı
[dc.identifier.endpage]
243
Dergi Adı
[dc.relation.journal]
JOURNAL OF THEORETICAL BIOLOGY
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
233
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.jtbi.2004.10.005
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/1935
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Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
267
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
18 Temmuz 2024 00:23
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Tıklayınız
functions coefficients kinetic constant activation inactivation constants experimental empirical channels fitted behavior validity neurons calcium T-type thalamic steady-state channel itself reflect powerful reserved rights Elsevier determine provide indicator related particular depending variation considerable curves functional
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