Imaging findings of pulmonary granulomatosis with polyangiitis (Wegener's granulomatosis): lesions invading the pulmonary fissure, pleura or diaphragm mimicking malignancy

Granulomatosis with polyangiitis (GPA, formerly Wegener's granulomatosis), in which pulmonary involvement often predominates, is a multisystem granulomatous, necrotizing vasculitis that affects small and medium-sized vessels. In this study we evaluated various radiological findings of pulmonary GPA and focused on spiculated pulmonary lesions invading the pulmonary fissure, pleura or diaphragm mimicking malignancy. This retrospective study included 48 patients, aged 28-73 (mean, 47.3) years, who showed either histopathological diagnosis of GPA (n = 39) or elevated levels of the cytoplasmic anti-neutrophilic cytoplasmic antibody serum marker (n = 9) between January 2003 and December 2013. All patients received a chest computed tomography (CT), and the types of pulmonary lesions were defined and evaluated. Among the 48 patients, 33 had abnormal pulmonary findings on CT. The most commonly detected pulmonary lesion types were nodules and masses (n = 126) observed in 24 patients. Cavitation, necrosis, spiculation and invasion of the fissure, pleura or diaphragm were observed in 14, 9, 10 and 6 patients, respectively. Consolidation was found in 14 patients and thickening of bronchial wall in 8 patients. Pulmonary lesion types of GPA have a wide spectrum, potentially mimicking a high number of diseases including malignancy, infection and noninfectious inflammatory diseases. A spiculated lung lesion invading the fissure, pleura or diaphragm is mostly present in malignancy, but it can be also seen in GPA.

Yazar Guneyli, Serkan
Ceylan, Naim
Bayraktaroglu, Selen
Gucenmez, Sercan
Aksu, Kenan
Kocacelebi, Kenan
Acar, Turker
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2745
Tek Biçim Adres 10.1007/s00508-015-0747-1
Konu Başlıkları Computed tomography
Granulomatous
Invasion
Pulmonary
Vasculitis
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı WIENER KLINISCHE WOCHENSCHRIFT
Dergi Cilt Bilgisi 128
Dergi Sayısı 21-22
Sayfalar 809 - 815
Yayın Yılı 2016
Eser Adı
[dc.title]
Imaging findings of pulmonary granulomatosis with polyangiitis (Wegener's granulomatosis): lesions invading the pulmonary fissure, pleura or diaphragm mimicking malignancy
Yazar
[dc.contributor.author]
Guneyli, Serkan
Yazar
[dc.contributor.author]
Ceylan, Naim
Yazar
[dc.contributor.author]
Bayraktaroglu, Selen
Yazar
[dc.contributor.author]
Gucenmez, Sercan
Yazar
[dc.contributor.author]
Aksu, Kenan
Yazar
[dc.contributor.author]
Kocacelebi, Kenan
Yazar
[dc.contributor.author]
Acar, Turker
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
SPRINGER WIEN
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Granulomatosis with polyangiitis (GPA, formerly Wegener's granulomatosis), in which pulmonary involvement often predominates, is a multisystem granulomatous, necrotizing vasculitis that affects small and medium-sized vessels. In this study we evaluated various radiological findings of pulmonary GPA and focused on spiculated pulmonary lesions invading the pulmonary fissure, pleura or diaphragm mimicking malignancy. This retrospective study included 48 patients, aged 28-73 (mean, 47.3) years, who showed either histopathological diagnosis of GPA (n = 39) or elevated levels of the cytoplasmic anti-neutrophilic cytoplasmic antibody serum marker (n = 9) between January 2003 and December 2013. All patients received a chest computed tomography (CT), and the types of pulmonary lesions were defined and evaluated. Among the 48 patients, 33 had abnormal pulmonary findings on CT. The most commonly detected pulmonary lesion types were nodules and masses (n = 126) observed in 24 patients. Cavitation, necrosis, spiculation and invasion of the fissure, pleura or diaphragm were observed in 14, 9, 10 and 6 patients, respectively. Consolidation was found in 14 patients and thickening of bronchial wall in 8 patients. Pulmonary lesion types of GPA have a wide spectrum, potentially mimicking a high number of diseases including malignancy, infection and noninfectious inflammatory diseases. A spiculated lung lesion invading the fissure, pleura or diaphragm is mostly present in malignancy, but it can be also seen in GPA.
Açıklama
[dc.description]
WOS: 000388193400006
Açıklama
[dc.description]
PubMed: 25860849
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Computed tomography
Konu Başlıkları
[dc.subject]
Granulomatous
Konu Başlıkları
[dc.subject]
Invasion
Konu Başlıkları
[dc.subject]
Pulmonary
Konu Başlıkları
[dc.subject]
Vasculitis
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0043-5325
ISSN
[dc.identifier.issn]
1613-7671
İlk Sayfa Sayısı
[dc.identifier.startpage]
809
Son Sayfa Sayısı
[dc.identifier.endpage]
815
Dergi Adı
[dc.relation.journal]
WIENER KLINISCHE WOCHENSCHRIFT
Dergi Sayısı
[dc.identifier.issue]
21-22
Dergi Cilt Bilgisi
[dc.identifier.volume]
128
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1007/s00508-015-0747-1
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2745
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
33
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 08:20
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Tıklayınız
patients pulmonary malignancy lesion diaphragm pleura fissure evaluated mimicking observed cytoplasmic invading lesions spiculated findings diseases invasion spiculation necrosis Cavitation defined masses nodules abnormal detected commonly infection bronchial number noninfectious potentially spectrum Pulmonary inflammatory mostly
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