Intravesical Prostatic Protrusion: A Potential Marker of Alpha-blocker Treatment Success in Patients With Benign Prostatic Enlargement

OBJECTIVE To investigate the value of anatomic and blood-flow measurements of the prostate via ultrasound in identifying medical treatment response of patients with lower urinary tract symptoms due to benign prostatic enlargement. A secondary objective of the study was to compare transabdominal-transrectal measurements. MATERIALS AND METHODS Male patients (age range 50-80) with lower urinary tract symptoms who applied to our outpatient clinic to be diagnosed with benign prostatic enlargement that were eligible for medical management were included in the prospective study. Patients (n = 49) were administered with tamsulosin for management. At baseline evaluation, all patients underwent International Prostate Symptom Score (IPSS), prostate-specific antigen (PSA), transabdominal and transrectal ultrasound [prostate volume (PV), post-void rezidu and intravesical prostatic protrusion (IPP)], and prostate subcapsular resistive index value measurement. Follow-ups were carried out 1 and 3 months after treatment. At these time-points, patients were assessed with IPSS and uroflowmetry. RESULTS IPP were identified to be negatively correlated with baseline Qmax values (P =.001, R = -0.485) and positively correlated with PSA (P = .013, R = 0.353) and PV (P = .003, R = 0.420). PV was related with resistive index (P = .026, R = 0.318) and PSA (P = .001, R = 0.619). Subsequent to medical treatment on the follow-ups, an overall improvement in the IPSS and Qmax was identified (P = .001). However, a negative correlation was identified in the change that occurred between IPSS and IPP (P = .004, R = -0.410). Other parameters were not correlated (P > .05) with the change in IPSS and Qmax. Transabdominal and transrectal measures were similar (P = .001). CONCLUSION This study has shown that increased IPP values are associated with lower response to alphareceptor specific management. Transabdominal measurements are sufficient for the evaluation compared with transrectal measurement. (C) 2016 Elsevier Inc.

Yazar Kalkanli, Arif
Tandogdu, Zafer
Aydin, Muammer
Karaca, Alaettin Sener
Hazar, Aydin Ismet
Balci, Mustafa Bahadir Can
Aydin, Memduh
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2811
Tek Biçim Adres 10.1016/j.urology.2015.11.029
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı UROLOGY
Dergi Cilt Bilgisi 88
Sayfalar 161 - 165
Yayın Yılı 2016
Eser Adı
[dc.title]
Intravesical Prostatic Protrusion: A Potential Marker of Alpha-blocker Treatment Success in Patients With Benign Prostatic Enlargement
Yazar
[dc.contributor.author]
Kalkanli, Arif
Yazar
[dc.contributor.author]
Tandogdu, Zafer
Yazar
[dc.contributor.author]
Aydin, Muammer
Yazar
[dc.contributor.author]
Karaca, Alaettin Sener
Yazar
[dc.contributor.author]
Hazar, Aydin Ismet
Yazar
[dc.contributor.author]
Balci, Mustafa Bahadir Can
Yazar
[dc.contributor.author]
Aydin, Memduh
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
ELSEVIER SCIENCE INC
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
OBJECTIVE To investigate the value of anatomic and blood-flow measurements of the prostate via ultrasound in identifying medical treatment response of patients with lower urinary tract symptoms due to benign prostatic enlargement. A secondary objective of the study was to compare transabdominal-transrectal measurements. MATERIALS AND METHODS Male patients (age range 50-80) with lower urinary tract symptoms who applied to our outpatient clinic to be diagnosed with benign prostatic enlargement that were eligible for medical management were included in the prospective study. Patients (n = 49) were administered with tamsulosin for management. At baseline evaluation, all patients underwent International Prostate Symptom Score (IPSS), prostate-specific antigen (PSA), transabdominal and transrectal ultrasound [prostate volume (PV), post-void rezidu and intravesical prostatic protrusion (IPP)], and prostate subcapsular resistive index value measurement. Follow-ups were carried out 1 and 3 months after treatment. At these time-points, patients were assessed with IPSS and uroflowmetry. RESULTS IPP were identified to be negatively correlated with baseline Qmax values (P =.001, R = -0.485) and positively correlated with PSA (P = .013, R = 0.353) and PV (P = .003, R = 0.420). PV was related with resistive index (P = .026, R = 0.318) and PSA (P = .001, R = 0.619). Subsequent to medical treatment on the follow-ups, an overall improvement in the IPSS and Qmax was identified (P = .001). However, a negative correlation was identified in the change that occurred between IPSS and IPP (P = .004, R = -0.410). Other parameters were not correlated (P > .05) with the change in IPSS and Qmax. Transabdominal and transrectal measures were similar (P = .001). CONCLUSION This study has shown that increased IPP values are associated with lower response to alphareceptor specific management. Transabdominal measurements are sufficient for the evaluation compared with transrectal measurement. (C) 2016 Elsevier Inc.
Açıklama
[dc.description]
WOS: 000373464600041
Açıklama
[dc.description]
PubMed: 26680245
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0090-4295
ISSN
[dc.identifier.issn]
1527-9995
İlk Sayfa Sayısı
[dc.identifier.startpage]
161
Son Sayfa Sayısı
[dc.identifier.endpage]
165
Dergi Adı
[dc.relation.journal]
UROLOGY
Dergi Cilt Bilgisi
[dc.identifier.volume]
88
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.urology.2015.11.029
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2811
Görüntülenme Sayısı ( Şehir )
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Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
6
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
18 Ocak 2024 18:50
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Tıklayınız
patients transrectal management correlated identified prostatic measurements medical treatment change resistive baseline Transabdominal benign response ultrasound measurement prostate values evaluation urinary enlargement symptoms related sufficient positively Subsequent Elsevier negatively However specific alphareceptor associated increased CONCLUSION
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