The levels of visceral adipose tissue-derived serpin, omentin-1 and tumor necrosis factor-alpha in the gingival crevicular fluid of obese patients following periodontal therapy

The aim of this clinical study was to determine levels of visceral adipose tissue-derived serpin (vaspin), omentin-1, and tumor necrosis factor-alpha (TNF-alpha) in the gingival crevicular fluid (GCF) of obese and non-obese periodontitis patients following nonsurgical periodontal therapy. Seventy-six subjects were separated into four groups according to periodontal and anthropometric measurements: a periodontal-healthy group, a chronic periodontitis (CP) group, a periodontal-healthy with obesity group, and a CP with obesity group. Nonsurgical periodontal treatment was administered to periodontitis patients. Before treatment and at 6 weeks after treatment, GCF samples were analyzed and clinical periodontal parameters were examined. Enzyme-linked immunosorbent assays were used to measure the levels of vaspin, omentin-1, and TNF-a. Obese and non-obese CP patients displayed higher levels of vaspin and TNF-alpha (P < 0.008), which declined following treatment (P< 0.025), and lower omentin levels (P <0.008), which increased after treatment (P < 0.025). There was a negative correlation between the total amount of vaspin and omentin-1 in all groups. Obese and non-obese patients had opposing levels of vaspin and omentin-1 in the GCF; therefore, these may represent diagnostic and prognostic indicators of periodontal disease and therapeutic outcome.

Yazar Balli, Umut
Dogan, Seyma Bozkurt
Dede, Figen Ongoz
Sertoglu, Erdim
Keles, Gonca Cayir
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3624
Tek Biçim Adres 10.2334/josnusd.16-0212
Konu Başlıkları visceral adipose-specific serpin
human omentin-1 protein
human
tumor necrosis factor-alpha
periodontal disease
obesity
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı JOURNAL OF ORAL SCIENCE
Dergi Cilt Bilgisi 58
Dergi Sayısı 4
Sayfalar 465 - 473
Yayın Yılı 2016
Eser Adı
[dc.title]
The levels of visceral adipose tissue-derived serpin, omentin-1 and tumor necrosis factor-alpha in the gingival crevicular fluid of obese patients following periodontal therapy
Yazar
[dc.contributor.author]
Balli, Umut
Yazar
[dc.contributor.author]
Dogan, Seyma Bozkurt
Yazar
[dc.contributor.author]
Dede, Figen Ongoz
Yazar
[dc.contributor.author]
Sertoglu, Erdim
Yazar
[dc.contributor.author]
Keles, Gonca Cayir
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
NIHON UNIV, SCHOOL DENTISTRY
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
The aim of this clinical study was to determine levels of visceral adipose tissue-derived serpin (vaspin), omentin-1, and tumor necrosis factor-alpha (TNF-alpha) in the gingival crevicular fluid (GCF) of obese and non-obese periodontitis patients following nonsurgical periodontal therapy. Seventy-six subjects were separated into four groups according to periodontal and anthropometric measurements: a periodontal-healthy group, a chronic periodontitis (CP) group, a periodontal-healthy with obesity group, and a CP with obesity group. Nonsurgical periodontal treatment was administered to periodontitis patients. Before treatment and at 6 weeks after treatment, GCF samples were analyzed and clinical periodontal parameters were examined. Enzyme-linked immunosorbent assays were used to measure the levels of vaspin, omentin-1, and TNF-a. Obese and non-obese CP patients displayed higher levels of vaspin and TNF-alpha (P < 0.008), which declined following treatment (P< 0.025), and lower omentin levels (P <0.008), which increased after treatment (P < 0.025). There was a negative correlation between the total amount of vaspin and omentin-1 in all groups. Obese and non-obese patients had opposing levels of vaspin and omentin-1 in the GCF; therefore, these may represent diagnostic and prognostic indicators of periodontal disease and therapeutic outcome.
Açıklama
[dc.description]
WOS: 000390087600003
Açıklama
[dc.description]
PubMed: 28025429
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
visceral adipose-specific serpin
Konu Başlıkları
[dc.subject]
human omentin-1 protein
Konu Başlıkları
[dc.subject]
human
Konu Başlıkları
[dc.subject]
tumor necrosis factor-alpha
Konu Başlıkları
[dc.subject]
periodontal disease
Konu Başlıkları
[dc.subject]
obesity
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1343-4934
ISSN
[dc.identifier.issn]
1880-4926
İlk Sayfa Sayısı
[dc.identifier.startpage]
465
Son Sayfa Sayısı
[dc.identifier.endpage]
473
Dergi Adı
[dc.relation.journal]
JOURNAL OF ORAL SCIENCE
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
58
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.2334/josnusd.16-0212
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3624
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
13
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 19:57
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Tıklayınız
treatment periodontal levels omentin-1 patients vaspin periodontitis non-obese periodontal-healthy following obesity groups clinical TNF-alpha higher displayed measure declined negative therefore outcome therapeutic disease indicators prognostic diagnostic represent opposing omentin amount between correlation immunosorbent increased assays
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