A severe case of Weil's disease

Leptospirosis which is caused by Leptospira species, may present with clinical features that vary from a mild flu-like illness to an acute life-threatening condition. Weil's disease, the most severe form of leptospirosis is characterized by multiorgan involvement including liver, kidney and lungs. In this report a severe Weil's disease was presented. A 43 years old male patient who had a history of swallowing water while swimming in the creek, was admitted to the hospital with the complaints of weakness, cough, bloody sputum, generalized jaundice and dark urine. Acute renal failure, bilateral lung infiltration, hyperbilirubinemia, leukocytosis and thrombocytopenia were detected, and the patient has undergone to hemodialysis. Ceftriaxone and ciprofloxacin treatment was applied to the patient after collection of blood, urine and sputum cultures and serum samples for serological tests. None of the cultures yielded pathogenic microorganisms. Microscopic agglutination test (MAT) was applied to two serum samples which were collected with 10 days interval. The first serum sample revealed antibody positivity at 1/200 titer against L.semeranga Patoc 1, while the second serum revealed antibody positivity at 1/400 titer against both L.semeranga Patoc I and L.icterohaemorrhagiae Wijnberg. By the administration of antibiotic therapy and early supportive care the patient was cured completely. In conclusion Weil's disease should be taken into consideration in the patients with multiple organ involvements.

Yazar Aydemir, Hande
Akduman, Deniz
Oztoprak, Nefise
Piskin, Nihal
Celebi, Guven
Akkoyunlu, Yasemin
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/1993
Konu Başlıkları Leptospira
leptospirosis
Weil disease
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı MIKROBIYOLOJI BULTENI
Dergi Cilt Bilgisi 41
Dergi Sayısı 1
Sayfalar 145 - 150
Yayın Yılı 2007
Eser Adı
[dc.title]
A severe case of Weil's disease
Yazar
[dc.contributor.author]
Aydemir, Hande
Yazar
[dc.contributor.author]
Akduman, Deniz
Yazar
[dc.contributor.author]
Oztoprak, Nefise
Yazar
[dc.contributor.author]
Piskin, Nihal
Yazar
[dc.contributor.author]
Celebi, Guven
Yazar
[dc.contributor.author]
Akkoyunlu, Yasemin
Yayın Yılı
[dc.date.issued]
2007
Yayıncı
[dc.publisher]
ANKARA MICROBIOLOGY SOC
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Leptospirosis which is caused by Leptospira species, may present with clinical features that vary from a mild flu-like illness to an acute life-threatening condition. Weil's disease, the most severe form of leptospirosis is characterized by multiorgan involvement including liver, kidney and lungs. In this report a severe Weil's disease was presented. A 43 years old male patient who had a history of swallowing water while swimming in the creek, was admitted to the hospital with the complaints of weakness, cough, bloody sputum, generalized jaundice and dark urine. Acute renal failure, bilateral lung infiltration, hyperbilirubinemia, leukocytosis and thrombocytopenia were detected, and the patient has undergone to hemodialysis. Ceftriaxone and ciprofloxacin treatment was applied to the patient after collection of blood, urine and sputum cultures and serum samples for serological tests. None of the cultures yielded pathogenic microorganisms. Microscopic agglutination test (MAT) was applied to two serum samples which were collected with 10 days interval. The first serum sample revealed antibody positivity at 1/200 titer against L.semeranga Patoc 1, while the second serum revealed antibody positivity at 1/400 titer against both L.semeranga Patoc I and L.icterohaemorrhagiae Wijnberg. By the administration of antibiotic therapy and early supportive care the patient was cured completely. In conclusion Weil's disease should be taken into consideration in the patients with multiple organ involvements.
Açıklama
[dc.description]
WOS: 000246531100019
Açıklama
[dc.description]
PubMed: 17427565
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Leptospira
Konu Başlıkları
[dc.subject]
leptospirosis
Konu Başlıkları
[dc.subject]
Weil disease
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0374-9096
İlk Sayfa Sayısı
[dc.identifier.startpage]
145
Son Sayfa Sayısı
[dc.identifier.endpage]
150
Dergi Adı
[dc.relation.journal]
MIKROBIYOLOJI BULTENI
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
41
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/1993
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
44
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 10:00
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Tıklayınız
patient disease against positivity antibody severe sputum revealed semeranga applied cultures samples collection serological microorganisms collected agglutination Microscopic yielded pathogenic interval Leptospirosis supportive involvements multiple patients consideration should conclusion completely sample therapy antibiotic administration Wijnberg
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