High mobility group B1 levels in sepsis and disseminated intravascular coagulation

Cytokines trigger coagulant and fibrinolytic systems in sepsis to result in Disseminated Intravascular Coagulation (DIC) that is an important complication and leads to disseminated hemorrhages and multi-organ failure. High Mobility Group B1 DNA Binding (HMGB1) protein is a cytokine taking part in systemic inflammatory response. The objective of this study was to investigate HMGB1 levels in groups of septic patients with and without DIC. Twenty-one septic patients without DIC and 12 septic patients with DIC from the Intensive Care Unit (ICU) were included in the study. In addition, 20 patients admitted to the ICU without sepsis or DIC and 20 healthy volunteers served as controls. Levels of HMGB1, prothrombin time, activated partial thromboplastin time, fibrinogen, D-dimer, protein C, protein S, anti-thrombin III (ATM), platelet (thrombocyte) and leukocyte count were determined. Levels of fibrinogen, protein C, ATIII and platelet count were significantly lower and D-dimer was significantly higher in the group with sepsis plus DIC compared to the group with sepsis without DIC. Levels of HMGB1 were higher in the group with sepsis and DIC compared to the group with sepsis; however, the difference was not statistically significant and the levels of HGMB1 of both groups were significantly higher compared to ICU and healthy control groups. HMGB1 levels were not significantly different in survivor and non survivor patients. HMGB1 levels did not differ in lower respiratory tract infection (LRTI) and urinary tract infection (UTI) in regard to the etiology of sepsis.

Yazar Eskici, Zeynep M.
Acikgoz, Serefden
Piskin, Nihal
Mungan, Gorkem
Can, Murat
Guven, Berrak
Kokturk, Furuzan
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2720
Konu Başlıkları sepsis
disseminated intravascular coagulation
HMGB1
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı ACTA BIOCHIMICA POLONICA
Dergi Cilt Bilgisi 59
Dergi Sayısı 4
Sayfalar 561 - 566
Yayın Yılı 2012
Eser Adı
[dc.title]
High mobility group B1 levels in sepsis and disseminated intravascular coagulation
Yazar
[dc.contributor.author]
Eskici, Zeynep M.
Yazar
[dc.contributor.author]
Acikgoz, Serefden
Yazar
[dc.contributor.author]
Piskin, Nihal
Yazar
[dc.contributor.author]
Mungan, Gorkem
Yazar
[dc.contributor.author]
Can, Murat
Yazar
[dc.contributor.author]
Guven, Berrak
Yazar
[dc.contributor.author]
Kokturk, Furuzan
Yayın Yılı
[dc.date.issued]
2012
Yayıncı
[dc.publisher]
ACTA BIOCHIMICA POLONICA
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Cytokines trigger coagulant and fibrinolytic systems in sepsis to result in Disseminated Intravascular Coagulation (DIC) that is an important complication and leads to disseminated hemorrhages and multi-organ failure. High Mobility Group B1 DNA Binding (HMGB1) protein is a cytokine taking part in systemic inflammatory response. The objective of this study was to investigate HMGB1 levels in groups of septic patients with and without DIC. Twenty-one septic patients without DIC and 12 septic patients with DIC from the Intensive Care Unit (ICU) were included in the study. In addition, 20 patients admitted to the ICU without sepsis or DIC and 20 healthy volunteers served as controls. Levels of HMGB1, prothrombin time, activated partial thromboplastin time, fibrinogen, D-dimer, protein C, protein S, anti-thrombin III (ATM), platelet (thrombocyte) and leukocyte count were determined. Levels of fibrinogen, protein C, ATIII and platelet count were significantly lower and D-dimer was significantly higher in the group with sepsis plus DIC compared to the group with sepsis without DIC. Levels of HMGB1 were higher in the group with sepsis and DIC compared to the group with sepsis; however, the difference was not statistically significant and the levels of HGMB1 of both groups were significantly higher compared to ICU and healthy control groups. HMGB1 levels were not significantly different in survivor and non survivor patients. HMGB1 levels did not differ in lower respiratory tract infection (LRTI) and urinary tract infection (UTI) in regard to the etiology of sepsis.
Açıklama
[dc.description]
WOS: 000313377200017
Açıklama
[dc.description]
PubMed: 23094260
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
sepsis
Konu Başlıkları
[dc.subject]
disseminated intravascular coagulation
Konu Başlıkları
[dc.subject]
HMGB1
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0001-527X
ISSN
[dc.identifier.issn]
1734-154X
İlk Sayfa Sayısı
[dc.identifier.startpage]
561
Son Sayfa Sayısı
[dc.identifier.endpage]
566
Dergi Adı
[dc.relation.journal]
ACTA BIOCHIMICA POLONICA
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
59
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2720
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
28
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Şubat 2024 09:03
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Tıklayınız
sepsis patients protein without levels significantly higher septic groups Levels compared platelet healthy infection D-dimer fibrinogen survivor controls anti-thrombin prothrombin partial thromboplastin activated Cytokines control etiology regard urinary (LRTI) respiratory differ different significant statistically difference
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