Association of (1,607) 1G/2G polymorphism of matrix metalloproteinase-1 gene with knee osteoarthritis in the Turkish population (knee osteoarthritis and MMPs gene polymorphisms)

The aim of this study was to investigate whether functional polymorphisms in the promoter of matrix metalloproteinase-1 (MMP-1), MMP-2 and MMP-9 genes were associated with susceptibility to knee osteoarthritis in the Turkish population. The MMP-1 -1,607 1G/2G (rs1799750), MMP-2 -1,306 C/T (rs243865), and MMP-9 -1,562 C/T (rs3918242) polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism assay in 157 patients diagnosed with knee osteoarthritis based on the criteria of American College of Rheumatology and in 84 controls in Mersin, Turkey. Genotype distributions and allele frequencies of MMP-1, MMP-2, and MMP-9 gene polymorphisms were compared between the patients and controls. There were significant differences between the groups regarding the genotype distribution of MMP-1 polymorphism (P = 0.001). The frequencies of 1G/1G and 1G/2G genotypes were significantly higher in the knee osteoarthritis than in the controls (P = 0.002, and P = 0.006, respectively). In addition, 1G allele frequency of MMP-1 gene was higher in the patients than in the control group (P = 0.0001). The genotype distributions and allele frequencies of MMP-2 and MMP-9 gene polymorphisms did not differ between the osteoarthritis and the control groups (P > 0.05). These findings suggest that the -1,607 1G/2G polymorphism in the MMP-1 gene may contribute to susceptibility to knee osteoarthritis in the Turkish population.

Yazar Barlas, I. Oemer
Sezgin, Melek
Erdal, M. Emin
Sahin, Guensah
Ankarali, Handan Camdeviren
Altintas, Zuehal Mert
Tuerkmen, Ebru
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2128
Tek Biçim Adres 10.1007/s00296-008-0705-6
Konu Başlıkları Knee osteoarthritis
MMP-1
MMP-2
MMP-9
Gene polymorphism
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı RHEUMATOLOGY INTERNATIONAL
Dergi Cilt Bilgisi 29
Dergi Sayısı 4
Sayfalar 383 - 388
Yayın Yılı 2009
Eser Adı
[dc.title]
Association of (1,607) 1G/2G polymorphism of matrix metalloproteinase-1 gene with knee osteoarthritis in the Turkish population (knee osteoarthritis and MMPs gene polymorphisms)
Yazar
[dc.contributor.author]
Barlas, I. Oemer
Yazar
[dc.contributor.author]
Sezgin, Melek
Yazar
[dc.contributor.author]
Erdal, M. Emin
Yazar
[dc.contributor.author]
Sahin, Guensah
Yazar
[dc.contributor.author]
Ankarali, Handan Camdeviren
Yazar
[dc.contributor.author]
Altintas, Zuehal Mert
Yazar
[dc.contributor.author]
Tuerkmen, Ebru
Yayın Yılı
[dc.date.issued]
2009
Yayıncı
[dc.publisher]
SPRINGER HEIDELBERG
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
The aim of this study was to investigate whether functional polymorphisms in the promoter of matrix metalloproteinase-1 (MMP-1), MMP-2 and MMP-9 genes were associated with susceptibility to knee osteoarthritis in the Turkish population. The MMP-1 -1,607 1G/2G (rs1799750), MMP-2 -1,306 C/T (rs243865), and MMP-9 -1,562 C/T (rs3918242) polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism assay in 157 patients diagnosed with knee osteoarthritis based on the criteria of American College of Rheumatology and in 84 controls in Mersin, Turkey. Genotype distributions and allele frequencies of MMP-1, MMP-2, and MMP-9 gene polymorphisms were compared between the patients and controls. There were significant differences between the groups regarding the genotype distribution of MMP-1 polymorphism (P = 0.001). The frequencies of 1G/1G and 1G/2G genotypes were significantly higher in the knee osteoarthritis than in the controls (P = 0.002, and P = 0.006, respectively). In addition, 1G allele frequency of MMP-1 gene was higher in the patients than in the control group (P = 0.0001). The genotype distributions and allele frequencies of MMP-2 and MMP-9 gene polymorphisms did not differ between the osteoarthritis and the control groups (P > 0.05). These findings suggest that the -1,607 1G/2G polymorphism in the MMP-1 gene may contribute to susceptibility to knee osteoarthritis in the Turkish population.
Açıklama
[dc.description]
WOS: 000263098200005
Açıklama
[dc.description]
PubMed: 18802702
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Knee osteoarthritis
Konu Başlıkları
[dc.subject]
MMP-1
Konu Başlıkları
[dc.subject]
MMP-2
Konu Başlıkları
[dc.subject]
MMP-9
Konu Başlıkları
[dc.subject]
Gene polymorphism
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0172-8172
ISSN
[dc.identifier.issn]
1437-160X
İlk Sayfa Sayısı
[dc.identifier.startpage]
383
Son Sayfa Sayısı
[dc.identifier.endpage]
388
Dergi Adı
[dc.relation.journal]
RHEUMATOLOGY INTERNATIONAL
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
29
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1007/s00296-008-0705-6
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2128
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
5
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
10 Aralık 2023 16:42
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Tıklayınız
osteoarthritis polymorphisms polymorphism patients frequencies between allele controls higher control genotype population Turkish distributions susceptibility groups differences distribution genotypes significantly regarding differ contribute suggest findings frequency addition respectively) significant criteria (MMP-1) (rs3918242) (rs243865) (rs1799750) associated
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