Viral studies in the cerebrospinal fluid in subacute sclerosing panencephalitis

Objectives: The pathogenesis of subacute sclerosing panencephalitis (SSPE), and particularly, the cause of measles virus (MV) reactivation following a latent period after primary measles infection is unknown. The hypothesis of other viruses contributing to the pathogenesis of SSPE by affecting the in vivo state of MV was Investigated. Methods: We examined the cerebrospinal fluid of SSPE patients (n = 43) for DNA or RNA and antibodies against HSV type I and 2, EBV, CMV, VZV, Hepatitis B, Hepatitis C JC virus, human herpesvirus (HHV)-6, HHV-7, HHV-8, HTLV-1, and HTLV-2. We compared the findings with those of patients with other neurological disorders (n = 39). Results: CMV DNA and HSV type I IgG were found more frequently in SSPE patients. Other positive results were at similar incidence in SSPE and control groups. The clinical features of SSPE cases with and without positive viral tests did not differ from each other. Conclusion: These data do not support a specific role for these agents in SSPE, but imply that the passage of some viruses to the CNS and local antibody synthesis may be facilitated by inflammation. The persistence or reactivation of MV in SSPE may be related to other factors pertaining to the host or environment. (C) 2002 The British Infection Society.

Yazar Anlar, B
Pinar, A
Anlar, FY
Engin, D
Ustacelebi, S
Kocagoz, T
Us, D
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3775
Tek Biçim Adres 10.1053/jinf.2002.0974
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı JOURNAL OF INFECTION
Dergi Cilt Bilgisi 44
Dergi Sayısı 3
Sayfalar 176 - 180
Yayın Yılı 2002
Eser Adı
[dc.title]
Viral studies in the cerebrospinal fluid in subacute sclerosing panencephalitis
Yazar
[dc.contributor.author]
Anlar, B
Yazar
[dc.contributor.author]
Pinar, A
Yazar
[dc.contributor.author]
Anlar, FY
Yazar
[dc.contributor.author]
Engin, D
Yazar
[dc.contributor.author]
Ustacelebi, S
Yazar
[dc.contributor.author]
Kocagoz, T
Yazar
[dc.contributor.author]
Us, D
Yayın Yılı
[dc.date.issued]
2002
Yayıncı
[dc.publisher]
W B SAUNDERS CO LTD
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objectives: The pathogenesis of subacute sclerosing panencephalitis (SSPE), and particularly, the cause of measles virus (MV) reactivation following a latent period after primary measles infection is unknown. The hypothesis of other viruses contributing to the pathogenesis of SSPE by affecting the in vivo state of MV was Investigated. Methods: We examined the cerebrospinal fluid of SSPE patients (n = 43) for DNA or RNA and antibodies against HSV type I and 2, EBV, CMV, VZV, Hepatitis B, Hepatitis C JC virus, human herpesvirus (HHV)-6, HHV-7, HHV-8, HTLV-1, and HTLV-2. We compared the findings with those of patients with other neurological disorders (n = 39). Results: CMV DNA and HSV type I IgG were found more frequently in SSPE patients. Other positive results were at similar incidence in SSPE and control groups. The clinical features of SSPE cases with and without positive viral tests did not differ from each other. Conclusion: These data do not support a specific role for these agents in SSPE, but imply that the passage of some viruses to the CNS and local antibody synthesis may be facilitated by inflammation. The persistence or reactivation of MV in SSPE may be related to other factors pertaining to the host or environment. (C) 2002 The British Infection Society.
Açıklama
[dc.description]
WOS: 000177097100006
Açıklama
[dc.description]
PubMed: 12099745
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0163-4453
İlk Sayfa Sayısı
[dc.identifier.startpage]
176
Son Sayfa Sayısı
[dc.identifier.endpage]
180
Dergi Adı
[dc.relation.journal]
JOURNAL OF INFECTION
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
44
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1053/jinf.2002.0974
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3775
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
12
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
13 Şubat 2024 18:31
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patients Hepatitis viruses positive pathogenesis measles reactivation clinical control results similar incidence differ without Conclusion features groups Objectives facilitated Society Infection British environment pertaining factors related persistence inflammation synthesis support antibody passage agents specific frequently
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