Effect of intraabdominal administration of Allium sativum (garlic) oil on postoperative peritoneal adhesione

Objective(s): Peritoneal adhesion is a serious problem that develops after most abdominopelvic surgeries. Allium sativum (garlic) has been used for centuries as both a nutrient and a traditional medicine. The anti-inflammatory, antibacterial, fibrinolytic, and wound-healing properties of garlic are well-recognized. We evaluated the effect of garlic on formation of postoperative adhesions in rats. Study design: Thirty Wistar-Albino female rats weighing 200-250 g were randomly divided into three groups (10 rats/group). Group 1 rats received 5 ml/kg garlic oil intraperitoneally and no surgery was performed. The ceca of Group 2 rats (controls) were scraped, to trigger adhesion formation, and no treatment was given. In Group 3 rats, 5 ml/kg garlic oil was added to the peritoneal cavity immediately after the cecum was scraped. All animals were sacrificed 10 d after surgery and adhesions graded in terms of severity and histopathologic characteristics. Results: All animals tolerated the operations well. No adhesions were evident upon laparotomy of Group 1 animals. In Group 2 three rats had an adhesion grade 2 and seven rats had an adhesion of grade 3, whereas in Group 3 no adhesions were found in four rats, five rats had an adhesion grade of 1. Only one rat had a grade 2 adhesion. Macroscopic adhesions and mean adhesion scores of Group 3 were significantly lower than Group 2(p < 0.001). Histopathologic evaluation of the specimens also revealed a statistically significant differences in inflammation, fibrosis, and neovascularization scores between Group 2 and 3 (p = 0.001, p = 0.001, and p = 0.011, respectively). Inflammation, fibrosis and vascularization scores in Group 3 were found significantly lower than Group 2. Conclusion: The anti-inflammatory, antibacterial, fibrinolytic, antithrombotic, and wound-healing effects of garlic likely prevent formation of peritoneal adhesions in a rat model, and garlic may be effective and cheap when used to prevent such adhesions in humans. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

Yazar Sahbaz, Ahmet
Isik, Hatice
Aynioglu, Oner
Gungorduk, Kemal
Gun, Banu Dogan
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2452
Tek Biçim Adres 10.1016/j.ejogrb.2014.03.018
Konu Başlıkları Adhesion
Allium sativum
Garlic
Peritoneal
Prevention
Postoperative
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
Dergi Cilt Bilgisi 177
Sayfalar 44 - 47
Yayın Yılı 2014
Eser Adı
[dc.title]
Effect of intraabdominal administration of Allium sativum (garlic) oil on postoperative peritoneal adhesione
Yazar
[dc.contributor.author]
Sahbaz, Ahmet
Yazar
[dc.contributor.author]
Isik, Hatice
Yazar
[dc.contributor.author]
Aynioglu, Oner
Yazar
[dc.contributor.author]
Gungorduk, Kemal
Yazar
[dc.contributor.author]
Gun, Banu Dogan
Yayın Yılı
[dc.date.issued]
2014
Yayıncı
[dc.publisher]
ELSEVIER SCIENCE BV
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective(s): Peritoneal adhesion is a serious problem that develops after most abdominopelvic surgeries. Allium sativum (garlic) has been used for centuries as both a nutrient and a traditional medicine. The anti-inflammatory, antibacterial, fibrinolytic, and wound-healing properties of garlic are well-recognized. We evaluated the effect of garlic on formation of postoperative adhesions in rats. Study design: Thirty Wistar-Albino female rats weighing 200-250 g were randomly divided into three groups (10 rats/group). Group 1 rats received 5 ml/kg garlic oil intraperitoneally and no surgery was performed. The ceca of Group 2 rats (controls) were scraped, to trigger adhesion formation, and no treatment was given. In Group 3 rats, 5 ml/kg garlic oil was added to the peritoneal cavity immediately after the cecum was scraped. All animals were sacrificed 10 d after surgery and adhesions graded in terms of severity and histopathologic characteristics. Results: All animals tolerated the operations well. No adhesions were evident upon laparotomy of Group 1 animals. In Group 2 three rats had an adhesion grade 2 and seven rats had an adhesion of grade 3, whereas in Group 3 no adhesions were found in four rats, five rats had an adhesion grade of 1. Only one rat had a grade 2 adhesion. Macroscopic adhesions and mean adhesion scores of Group 3 were significantly lower than Group 2(p < 0.001). Histopathologic evaluation of the specimens also revealed a statistically significant differences in inflammation, fibrosis, and neovascularization scores between Group 2 and 3 (p = 0.001, p = 0.001, and p = 0.011, respectively). Inflammation, fibrosis and vascularization scores in Group 3 were found significantly lower than Group 2. Conclusion: The anti-inflammatory, antibacterial, fibrinolytic, antithrombotic, and wound-healing effects of garlic likely prevent formation of peritoneal adhesions in a rat model, and garlic may be effective and cheap when used to prevent such adhesions in humans. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
Açıklama
[dc.description]
WOS: 000337863200008
Açıklama
[dc.description]
PubMed: 24793933
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Adhesion
Konu Başlıkları
[dc.subject]
Allium sativum
Konu Başlıkları
[dc.subject]
Garlic
Konu Başlıkları
[dc.subject]
Peritoneal
Konu Başlıkları
[dc.subject]
Prevention
Konu Başlıkları
[dc.subject]
Postoperative
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0301-2115
ISSN
[dc.identifier.issn]
1872-7654
İlk Sayfa Sayısı
[dc.identifier.startpage]
44
Son Sayfa Sayısı
[dc.identifier.endpage]
47
Dergi Adı
[dc.relation.journal]
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
Dergi Cilt Bilgisi
[dc.identifier.volume]
177
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.ejogrb.2014.03.018
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2452
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
12
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 07:22
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Tıklayınız
adhesion adhesions garlic animals scores formation significantly fibrosis surgery fibrinolytic peritoneal prevent anti-inflammatory antibacterial wound-healing scraped Macroscopic whereas laparotomy Objective(s) differences effective humans effects Elsevier Ireland rights reserved likely antithrombotic Histopathologic evaluation specimens revealed statistically
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