An assessment of the relationship between thyroid nodule characteristics, insulin resistance and arterial stiffness in euthyroid nodular goiter

ObjectivesPublications suggesting that thyroid nodule might be associated with insulin resistance and metabolic syndrome are quite interesting. There is a need for studies assessing the relationship between nodule presence and cardiovascular risk in individuals with non-functioning nodular goiter. The purpose of the present study is to reveal whether or not insulin resistance, nodule presence, and nodule stiffness affect arterial stiffness, which is a reliable and valid cardiovascular risk indicator, in individuals with euthyroid nodular goiter using the pulse wave analysis (PWA).Materials and methods50 patients with euthyroid nodular goiter and 50 healthy volunteers were included in the study. All participants were examined by B-mode thyroid ultrasound, and the participants in the nodular goiter group were also examined by strain elastography (SE). The strain index of nodules was calculated according to the Rago scoring. Also, fasting plasma glucose (FPG) and insulin levels were measured, and HOMA-IR. Arterial stiffness measurements of the participants were performed using a PWA device which employs a cuff-based oscillometric method from the brachial artery.ResultsPWV was found to be significantly higher in the euthyroid nodular goiter group (p<0.001). PWV was found to be positively correlated with FPG and waist circumference. Fasting plasma glucose was found to be higher in the group with nodular goiter (p=0.03). However, no difference was found between the groups in terms of HOMA-IR and insulin level. HOMA-IR was not correlated with thyroid volume, nodule volume, and nodule count. Also, HOMA-IR was not correlated with strain index value and PWA data.ConclusionWe found that PWV was significantly higher in patients with euthyroid nodular goiter. This result suggests that these patients may be at risk for cardiovascular disease.

Yazar Aydogan, Yasemin
Altay, Mustafa
Unsal, Oktay
Kaplanoglu, Veysel
Cagir, Yavuz
Yildiz, Canan
Beyan, Esin
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2042
Tek Biçim Adres 10.1007/s12020-018-1701-6
Konu Başlıkları Euthyroid nodular goiter
Insulin resistance
Strain index
Pulse wave velocity
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı ENDOCRINE
Dergi Cilt Bilgisi 62
Dergi Sayısı 2
Sayfalar 440 - 447
Yayın Yılı 2018
Eser Adı
[dc.title]
An assessment of the relationship between thyroid nodule characteristics, insulin resistance and arterial stiffness in euthyroid nodular goiter
Yazar
[dc.contributor.author]
Aydogan, Yasemin
Yazar
[dc.contributor.author]
Altay, Mustafa
Yazar
[dc.contributor.author]
Unsal, Oktay
Yazar
[dc.contributor.author]
Kaplanoglu, Veysel
Yazar
[dc.contributor.author]
Cagir, Yavuz
Yazar
[dc.contributor.author]
Yildiz, Canan
Yazar
[dc.contributor.author]
Beyan, Esin
Yayın Yılı
[dc.date.issued]
2018
Yayıncı
[dc.publisher]
SPRINGER
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
ObjectivesPublications suggesting that thyroid nodule might be associated with insulin resistance and metabolic syndrome are quite interesting. There is a need for studies assessing the relationship between nodule presence and cardiovascular risk in individuals with non-functioning nodular goiter. The purpose of the present study is to reveal whether or not insulin resistance, nodule presence, and nodule stiffness affect arterial stiffness, which is a reliable and valid cardiovascular risk indicator, in individuals with euthyroid nodular goiter using the pulse wave analysis (PWA).Materials and methods50 patients with euthyroid nodular goiter and 50 healthy volunteers were included in the study. All participants were examined by B-mode thyroid ultrasound, and the participants in the nodular goiter group were also examined by strain elastography (SE). The strain index of nodules was calculated according to the Rago scoring. Also, fasting plasma glucose (FPG) and insulin levels were measured, and HOMA-IR. Arterial stiffness measurements of the participants were performed using a PWA device which employs a cuff-based oscillometric method from the brachial artery.ResultsPWV was found to be significantly higher in the euthyroid nodular goiter group (p<0.001). PWV was found to be positively correlated with FPG and waist circumference. Fasting plasma glucose was found to be higher in the group with nodular goiter (p=0.03). However, no difference was found between the groups in terms of HOMA-IR and insulin level. HOMA-IR was not correlated with thyroid volume, nodule volume, and nodule count. Also, HOMA-IR was not correlated with strain index value and PWA data.ConclusionWe found that PWV was significantly higher in patients with euthyroid nodular goiter. This result suggests that these patients may be at risk for cardiovascular disease.
Açıklama
[dc.description]
WOS: 000449306400020
Açıklama
[dc.description]
PubMed: 30084100
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Euthyroid nodular goiter
Konu Başlıkları
[dc.subject]
Insulin resistance
Konu Başlıkları
[dc.subject]
Strain index
Konu Başlıkları
[dc.subject]
Pulse wave velocity
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1355-008X
ISSN
[dc.identifier.issn]
1559-0100
İlk Sayfa Sayısı
[dc.identifier.startpage]
440
Son Sayfa Sayısı
[dc.identifier.endpage]
447
Dergi Adı
[dc.relation.journal]
ENDOCRINE
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
62
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1007/s12020-018-1701-6
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2042
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
9
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 21:59
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Tıklayınız
nodular goiter nodule insulin HOMA-IR euthyroid correlated cardiovascular patients higher stiffness participants strain thyroid significantly plasma examined glucose individuals resistance volume between presence method oscillometric result cuff-based suggests employs brachial device performed measurements Arterial disease
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