c-Kit (CD117) expression in classic Kaposi's sarcoma
Background. Kaposi's sarcoma is a multicentric, low-grade, vascular neoplasia. Human herpesvirus 8 is associated with all epidemiological forms of KS and has been shown in vitro to induce the tyrosine receptor kinase c-Kit in infected cells. Aim. To investigate the expression of c-Kit in cases of classic KS and to clarify its association with clinicopathological parameters and HHV8 latency-associated nuclear antigen-1 expression. Methods. In total, 35 cases of classic KS at various histological stages were included in the study. Age and gender of the patients and location and histological stage of the tumours were recorded. Formalin-fixed, paraffin wax-embedded tissue sections were stained by immunohistochemistry with antibodies to c-Kit and HHV8. Results. c-Kit immunoreactivity was found in 22 cases and HHV8 immunoreactivity was present in all cases. There was no correlation in c-Kit immunoreactivity between clinicopathological parameters and HHV8 immunoreactivity. Conclusions. The results of our study show that in cases of classic KS there is a high rate of c-Kit immunoreactivity, but c-Kit expression does not show any correlation with HHV8 immunoreactivity.
| Yazar |
Kandemir, N. O. Gun, B. D. Bahadir, B. Yurdakan, G. Ozdemir, N. Karadayi, N. Ozdamar, S. O. |
| Yayın Türü | Article |
| Tek Biçim Adres | https://hdl.handle.net/20.500.12628/2225 |
| Tek Biçim Adres | 10.1111/j.1365-2230.2009.03661.x |
| Koleksiyonlar |
Fakülteler Tıp Fakültesi Cerrahi Bilimler Bölümü Makale Koleksiyonu (Cerrahi Bilimler Bölümü) Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD PubMed İndeksli Yayınlar Koleksiyonu Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD WoS İndeksli Yayınlar Koleksiyonu |
| Dergi Adı | CLINICAL AND EXPERIMENTAL DERMATOLOGY |
| Dergi Cilt Bilgisi | 35 |
| Dergi Sayısı | 5 |
| Sayfalar | 525 - 530 |
| Yayın Yılı | 2010 |
| Eser Adı [dc.title] | c-Kit (CD117) expression in classic Kaposi's sarcoma |
| Yazar [dc.contributor.author] | Kandemir, N. O. |
| Yazar [dc.contributor.author] | Gun, B. D. |
| Yazar [dc.contributor.author] | Bahadir, B. |
| Yazar [dc.contributor.author] | Yurdakan, G. |
| Yazar [dc.contributor.author] | Ozdemir, N. |
| Yazar [dc.contributor.author] | Karadayi, N. |
| Yazar [dc.contributor.author] | Ozdamar, S. O. |
| Yayın Yılı [dc.date.issued] | 2010 |
| Yayıncı [dc.publisher] | WILEY-BLACKWELL |
| Yayın Türü [dc.type] | article |
| Özet [dc.description.abstract] | Background. Kaposi's sarcoma is a multicentric, low-grade, vascular neoplasia. Human herpesvirus 8 is associated with all epidemiological forms of KS and has been shown in vitro to induce the tyrosine receptor kinase c-Kit in infected cells. Aim. To investigate the expression of c-Kit in cases of classic KS and to clarify its association with clinicopathological parameters and HHV8 latency-associated nuclear antigen-1 expression. Methods. In total, 35 cases of classic KS at various histological stages were included in the study. Age and gender of the patients and location and histological stage of the tumours were recorded. Formalin-fixed, paraffin wax-embedded tissue sections were stained by immunohistochemistry with antibodies to c-Kit and HHV8. Results. c-Kit immunoreactivity was found in 22 cases and HHV8 immunoreactivity was present in all cases. There was no correlation in c-Kit immunoreactivity between clinicopathological parameters and HHV8 immunoreactivity. Conclusions. The results of our study show that in cases of classic KS there is a high rate of c-Kit immunoreactivity, but c-Kit expression does not show any correlation with HHV8 immunoreactivity. |
| Açıklama [dc.description] | WOS: 000278564200016 |
| Açıklama [dc.description] | PubMed: 19874361 |
| Kayıt Giriş Tarihi [dc.date.accessioned] | 2019-12-23 |
| Açık Erişim Tarihi [dc.date.available] | 2019-12-23 |
| Yayın Dili [dc.language.iso] | eng |
| Haklar [dc.rights] | info:eu-repo/semantics/closedAccess |
| ISSN [dc.identifier.issn] | 0307-6938 |
| İlk Sayfa Sayısı [dc.identifier.startpage] | 525 |
| Son Sayfa Sayısı [dc.identifier.endpage] | 530 |
| Dergi Adı [dc.relation.journal] | CLINICAL AND EXPERIMENTAL DERMATOLOGY |
| Dergi Sayısı [dc.identifier.issue] | 5 |
| Dergi Cilt Bilgisi [dc.identifier.volume] | 35 |
| Tek Biçim Adres [dc.identifier.uri] | https://dx.doi.org/10.1111/j.1365-2230.2009.03661.x |
| Tek Biçim Adres [dc.identifier.uri] | https://hdl.handle.net/20.500.12628/2225 |
