Serum leptin, oxidized low density lipoprotein and plasma asymmetric dimethylarginine levels and their relationship with dyslipidaemia in adolescent girls with polycystic ovary syndrome

Objective The aim of this study was to investigate serum leptin, oxidized low density lipoprotein (ox-LDL) and asymmetric dimethylarginine (ADMA) levels and their interaction with dyslipidaemia in adolescents with polycystic ovary syndrome (PCOS). Patients and design The study group consisted of 23 obese (obPCOS) and 21 nonobese girls with PCOS (nPCOS), and 31 lean healthy controls. PCOS was defined by the National Institutes of Health (NIH) criteria as the presence of chronic oligoanovulation and hyperandrogenism. Fasting leptin, ox-LDL, ADMA and detailed lipid-lipoprotein profile were determined. Atherogenic index (AI) was calculated as [Total cholesterol - HDL cholesterol/HDL cholesterol]. Logarithmic transformations were made for ox-LDL. Results Total cholesterol, triglycerides, LDL cholesterol, very low density lipoprotein (VLDL) cholesterol, apolipoprotein B, lipoprotein A levels and AI were higher and apolipoprotein AI was lower in obPCOS compared to those in controls (P < 0.05). LDL cholesterol, apolipoprotein B and lipoprotein A levels were higher in nPCOS compared to controls (P < 0.05). ADMA and ox-LDL levels did not differ in the three groups. Leptin was significantly higher in obPCOS compared with that in the other two groups (P < 0.001) and it was correlated with triglycerides (r = 0.62), VLDL cholesterol (r = 0.45), lipoprotein A (r = 0.38) and AI (r = 0.43) in the PCOS group (P < 0.05). Conclusion Our data demonstrate that ADMA and ox-LDL levels in adolescent PCOS subjects were not different than those in controls. Abnormal lipid profile was shown in obese and nonobese girls with PCOS and leptin was related with these lipid abnormalities in the PCOS subjects.

Yazar Demirel, Fatma
Bideci, Aysun
Cinaz, Peyami
Camurdan, M. Orhun
Biberoglut, Guersel
Yesilkaya, Ediz
Hasanoglut, Alev
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3310
Tek Biçim Adres 10.1111/j.1365-2265.2007.02849.x
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı CLINICAL ENDOCRINOLOGY
Dergi Cilt Bilgisi 67
Dergi Sayısı 1
Sayfalar 129 - 134
Yayın Yılı 2007
Eser Adı
[dc.title]
Serum leptin, oxidized low density lipoprotein and plasma asymmetric dimethylarginine levels and their relationship with dyslipidaemia in adolescent girls with polycystic ovary syndrome
Yazar
[dc.contributor.author]
Demirel, Fatma
Yazar
[dc.contributor.author]
Bideci, Aysun
Yazar
[dc.contributor.author]
Cinaz, Peyami
Yazar
[dc.contributor.author]
Camurdan, M. Orhun
Yazar
[dc.contributor.author]
Biberoglut, Guersel
Yazar
[dc.contributor.author]
Yesilkaya, Ediz
Yazar
[dc.contributor.author]
Hasanoglut, Alev
Yayın Yılı
[dc.date.issued]
2007
Yayıncı
[dc.publisher]
BLACKWELL PUBLISHING
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective The aim of this study was to investigate serum leptin, oxidized low density lipoprotein (ox-LDL) and asymmetric dimethylarginine (ADMA) levels and their interaction with dyslipidaemia in adolescents with polycystic ovary syndrome (PCOS). Patients and design The study group consisted of 23 obese (obPCOS) and 21 nonobese girls with PCOS (nPCOS), and 31 lean healthy controls. PCOS was defined by the National Institutes of Health (NIH) criteria as the presence of chronic oligoanovulation and hyperandrogenism. Fasting leptin, ox-LDL, ADMA and detailed lipid-lipoprotein profile were determined. Atherogenic index (AI) was calculated as [Total cholesterol - HDL cholesterol/HDL cholesterol]. Logarithmic transformations were made for ox-LDL. Results Total cholesterol, triglycerides, LDL cholesterol, very low density lipoprotein (VLDL) cholesterol, apolipoprotein B, lipoprotein A levels and AI were higher and apolipoprotein AI was lower in obPCOS compared to those in controls (P < 0.05). LDL cholesterol, apolipoprotein B and lipoprotein A levels were higher in nPCOS compared to controls (P < 0.05). ADMA and ox-LDL levels did not differ in the three groups. Leptin was significantly higher in obPCOS compared with that in the other two groups (P < 0.001) and it was correlated with triglycerides (r = 0.62), VLDL cholesterol (r = 0.45), lipoprotein A (r = 0.38) and AI (r = 0.43) in the PCOS group (P < 0.05). Conclusion Our data demonstrate that ADMA and ox-LDL levels in adolescent PCOS subjects were not different than those in controls. Abnormal lipid profile was shown in obese and nonobese girls with PCOS and leptin was related with these lipid abnormalities in the PCOS subjects.
Açıklama
[dc.description]
WOS: 000247339300019
Açıklama
[dc.description]
PubMed: 17465999
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0300-0664
İlk Sayfa Sayısı
[dc.identifier.startpage]
129
Son Sayfa Sayısı
[dc.identifier.endpage]
134
Dergi Adı
[dc.relation.journal]
CLINICAL ENDOCRINOLOGY
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
67
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1111/j.1365-2265.2007.02849.x
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3310
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
9
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
05 Şubat 2024 20:36
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Tıklayınız
cholesterol lipoprotein levels ox-LDL controls higher apolipoprotein leptin compared nonobese groups triglycerides density subjects obPCOS profile (VLDL) Objective differ Conclusion abnormalities related Abnormal different adolescent demonstrate correlated Results significantly Leptin Atherogenic adolescents (nPCOS) (obPCOS) consisted
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