Prevalence of Gluten Sensitive Enteropathy antibodies in Restless Legs Syndrome

The prevalence of restless legs syndrome (RLS) is increased in gluten sensitive enteropathy (GSE); hut prevalence of GSE is not known in RLS. 96 RLS patients and 97 healthy controls, both with or without iron deficiency were enrolled. All secondary RLS patients except iron deficiency were excluded. Subjects underwent a thorough biochemistry and routine blood analyses, and tissue transglutaminase antibodies (TTGA), endomysium antibodies (EMA) and gliadin antibodies (AGA) were also tested. In RLS patients positivity rates of all GSE antibodies were similar to those in controls. The rate of iron deficiency anaemia in RLS patients with at least one positive GSE antibody was significantly higher than that of RLS patients whose GSE antibodies were all negative. The prevalence of GSE antibodies in RLS patients is not increased. GSE might have a role in the aetiology of RLS in association with iron deficiency anaemia. Since the prevalence of GSE antibodies is not increased in RLS, it seems unlikely that GSE is involved in the aetiology of RLS through different mechanisms (e.g. immunological mechanisms) other than iron deficiency as proposed in some published papers.

Yazar Cikrikcioglu, Mehmet Ali
Halac, Gulistan
Hursitoglu, Mehmet
Erkal, Hafize
Cakirca, Mustafa
Kinas, Burcin Erdem
Erek, Aybala
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3155
Konu Başlıkları Restless legs
gluten sensitive enteropathy
celiac disease
endomysium antibody
gliadin antibody
iron deficiency anaemia
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı ACTA NEUROLOGICA BELGICA
Dergi Cilt Bilgisi 111
Dergi Sayısı 4
Sayfalar 282 - 286
Yayın Yılı 2011
Eser Adı
[dc.title]
Prevalence of Gluten Sensitive Enteropathy antibodies in Restless Legs Syndrome
Yazar
[dc.contributor.author]
Cikrikcioglu, Mehmet Ali
Yazar
[dc.contributor.author]
Halac, Gulistan
Yazar
[dc.contributor.author]
Hursitoglu, Mehmet
Yazar
[dc.contributor.author]
Erkal, Hafize
Yazar
[dc.contributor.author]
Cakirca, Mustafa
Yazar
[dc.contributor.author]
Kinas, Burcin Erdem
Yazar
[dc.contributor.author]
Erek, Aybala
Yayın Yılı
[dc.date.issued]
2011
Yayıncı
[dc.publisher]
ACTA MEDICA BELGICA
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
The prevalence of restless legs syndrome (RLS) is increased in gluten sensitive enteropathy (GSE); hut prevalence of GSE is not known in RLS. 96 RLS patients and 97 healthy controls, both with or without iron deficiency were enrolled. All secondary RLS patients except iron deficiency were excluded. Subjects underwent a thorough biochemistry and routine blood analyses, and tissue transglutaminase antibodies (TTGA), endomysium antibodies (EMA) and gliadin antibodies (AGA) were also tested. In RLS patients positivity rates of all GSE antibodies were similar to those in controls. The rate of iron deficiency anaemia in RLS patients with at least one positive GSE antibody was significantly higher than that of RLS patients whose GSE antibodies were all negative. The prevalence of GSE antibodies in RLS patients is not increased. GSE might have a role in the aetiology of RLS in association with iron deficiency anaemia. Since the prevalence of GSE antibodies is not increased in RLS, it seems unlikely that GSE is involved in the aetiology of RLS through different mechanisms (e.g. immunological mechanisms) other than iron deficiency as proposed in some published papers.
Açıklama
[dc.description]
WOS: 000299907100005
Açıklama
[dc.description]
PubMed: 22368967
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Restless legs
Konu Başlıkları
[dc.subject]
gluten sensitive enteropathy
Konu Başlıkları
[dc.subject]
celiac disease
Konu Başlıkları
[dc.subject]
endomysium antibody
Konu Başlıkları
[dc.subject]
gliadin antibody
Konu Başlıkları
[dc.subject]
iron deficiency anaemia
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0300-9009
İlk Sayfa Sayısı
[dc.identifier.startpage]
282
Son Sayfa Sayısı
[dc.identifier.endpage]
286
Dergi Adı
[dc.relation.journal]
ACTA NEUROLOGICA BELGICA
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
111
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3155
Görüntülenme Sayısı ( Şehir )
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6
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
10 Şubat 2024 02:17
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antibodies patients deficiency prevalence increased anaemia aetiology controls negative higher significantly antibody published papers positive immunological mechanisms mechanisms) different through involved unlikely proposed association similar enrolled without healthy secondary enteropathy sensitive gluten syndrome restless except
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