The effect of sugammadex on postoperative cognitive function and recovery

Background and objective: Sugammadex is the first selective relaxant binding agent. When compared with neostigmine, following sugammadex administration patients wake earlier and have shorter recovery times. In this study, we hypothesized that fast and clear awakening in patients undergoing general anesthesia has positive effects on cognitive functions in the early period after operation. Methods: Approved by the local ethical committee, 128 patients were enrolled in this randomized, prospective, controlled, double-blind study. Patients were allocated to either Sugammadex group (Group S) or the Neostigmine group (Group N). The primary outcome of the study was early postoperative cognitive recovery as measured by the Montreal Cognitive Assessment (MoCA) and Mini Mental State Examination (MMSE). After baseline assessment 12-24 h before the operation. After the operation, when the Modified Aldrete Recovery Score was >= 9 the MMSE and 1 h later the MoCA tests were repeated. Results: Although there was a reduction in MoCA and MMSE scores in both Group S and Group N between preoperative and postoperative scores, there was no statistically significant difference in the slopes (p > 0.05). The time to reach TOF 0.9 was 2.19 min in Group S and 6.47 min in Group N (p < 0.0001). Recovery time was 8.26 min in Group S and 16.93 min in Group N (p < 0.0001). Conclusion: We showed that the surgical procedure and/or accompanying anesthetic procedure may cause a temporary or permanent regression in cognitive function in the early postoperative period. However, better cognitive performance could not be proved in the Sugammadex compared to the Neostigmine. (C) 2015 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda.

Yazar Piskin, Ozcan
Kucukosman, Gamze
Altun, Deniz Utku
Cimencan, Murat
Ozen, Banu
Aydin, Bengu Gulhan
Okyay, Rahsan Dilek
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3535
Tek Biçim Adres 10.1016/j.bjane.2014.10.003
Konu Başlıkları Sugammadex
Neostigmine
Postoperative cognitive dysfunction
MMSE
MoCA
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı REVISTA BRASILEIRA DE ANESTESIOLOGIA
Dergi Cilt Bilgisi 66
Dergi Sayısı 4
Sayfalar 376 - 382
Yayın Yılı 2016
Eser Adı
[dc.title]
The effect of sugammadex on postoperative cognitive function and recovery
Yazar
[dc.contributor.author]
Piskin, Ozcan
Yazar
[dc.contributor.author]
Kucukosman, Gamze
Yazar
[dc.contributor.author]
Altun, Deniz Utku
Yazar
[dc.contributor.author]
Cimencan, Murat
Yazar
[dc.contributor.author]
Ozen, Banu
Yazar
[dc.contributor.author]
Aydin, Bengu Gulhan
Yazar
[dc.contributor.author]
Okyay, Rahsan Dilek
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
ELSEVIER SCIENCE INC
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background and objective: Sugammadex is the first selective relaxant binding agent. When compared with neostigmine, following sugammadex administration patients wake earlier and have shorter recovery times. In this study, we hypothesized that fast and clear awakening in patients undergoing general anesthesia has positive effects on cognitive functions in the early period after operation. Methods: Approved by the local ethical committee, 128 patients were enrolled in this randomized, prospective, controlled, double-blind study. Patients were allocated to either Sugammadex group (Group S) or the Neostigmine group (Group N). The primary outcome of the study was early postoperative cognitive recovery as measured by the Montreal Cognitive Assessment (MoCA) and Mini Mental State Examination (MMSE). After baseline assessment 12-24 h before the operation. After the operation, when the Modified Aldrete Recovery Score was >= 9 the MMSE and 1 h later the MoCA tests were repeated. Results: Although there was a reduction in MoCA and MMSE scores in both Group S and Group N between preoperative and postoperative scores, there was no statistically significant difference in the slopes (p > 0.05). The time to reach TOF 0.9 was 2.19 min in Group S and 6.47 min in Group N (p < 0.0001). Recovery time was 8.26 min in Group S and 16.93 min in Group N (p < 0.0001). Conclusion: We showed that the surgical procedure and/or accompanying anesthetic procedure may cause a temporary or permanent regression in cognitive function in the early postoperative period. However, better cognitive performance could not be proved in the Sugammadex compared to the Neostigmine. (C) 2015 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda.
Açıklama
[dc.description]
WOS: 000380843400008
Açıklama
[dc.description]
PubMed: 27157202
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Sugammadex
Konu Başlıkları
[dc.subject]
Neostigmine
Konu Başlıkları
[dc.subject]
Postoperative cognitive dysfunction
Konu Başlıkları
[dc.subject]
MMSE
Konu Başlıkları
[dc.subject]
MoCA
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0034-7094
ISSN
[dc.identifier.issn]
1806-907X
İlk Sayfa Sayısı
[dc.identifier.startpage]
376
Son Sayfa Sayısı
[dc.identifier.endpage]
382
Dergi Adı
[dc.relation.journal]
REVISTA BRASILEIRA DE ANESTESIOLOGIA
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
66
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.bjane.2014.10.003
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3535
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
26
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
07 Şubat 2024 17:21
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Tıklayınız
cognitive operation patients postoperative Sugammadex scores period Recovery Neostigmine (Group compared procedure recovery surgical between preoperative Sociedade statistically proved significant reduction Brasileira slopes Anestesiologia Published Although Elsevier Results repeated Editora difference performance Conclusion and/or accompanying
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