Cytomorphometric Characteristics of Buccal Mucosal Cells in Behcet's Disease Patients

Background. The aim of this study was to compare the cytomorphometric characteristics of the buccal cells of Behccet's disease patients with those of healthy controls. Methods. This case-control study compared a group of 30 patients with Behcet's disease with an age-and gender-matched control group of 30 healthy individuals. The buccal mucosal smears were stained using the Papanicolaou technique for cytomorphometric analyses. The nuclear and cytoplasmic areas were evaluated using digital image analysis; the ratio of nuclear to cytoplasmic areas and nuclear roundness are presented. Results. The nuclear and cytoplasmic areas of the BD patients' cells were significantly smaller than those of the healthy controls' cells, while the nucleus-to-cytoplasm ratio and neutrophil infiltration rate did not differ significantly between the groups. However, the nuclear area, cytoplasmic area, nucleus-to-cytoplasm ratio, and nuclear roundness factor were significantly higher in patients without aphthae. The neutrophil infiltration rate did not differ significantly in patients with or without aphthae. Conclusion. Behcet's disease can produce cytomorphometric changes in buccal cells that are detectable by exfoliative cytology and cytomorphometric analysis techniques.

Yazar Aktunc, Erol
Oz, Zehra Safi
Bektas, Sibel
Altinyazar, Cevdet
Koca, Rafet
Bostan, Serdar
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2335
Tek Biçim Adres 10.1155/2016/6035801
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı ANALYTICAL CELLULAR PATHOLOGY
Sayfalar -
Yayın Yılı 2016
Eser Adı
[dc.title]
Cytomorphometric Characteristics of Buccal Mucosal Cells in Behcet's Disease Patients
Yazar
[dc.contributor.author]
Aktunc, Erol
Yazar
[dc.contributor.author]
Oz, Zehra Safi
Yazar
[dc.contributor.author]
Bektas, Sibel
Yazar
[dc.contributor.author]
Altinyazar, Cevdet
Yazar
[dc.contributor.author]
Koca, Rafet
Yazar
[dc.contributor.author]
Bostan, Serdar
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
HINDAWI LTD
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background. The aim of this study was to compare the cytomorphometric characteristics of the buccal cells of Behccet's disease patients with those of healthy controls. Methods. This case-control study compared a group of 30 patients with Behcet's disease with an age-and gender-matched control group of 30 healthy individuals. The buccal mucosal smears were stained using the Papanicolaou technique for cytomorphometric analyses. The nuclear and cytoplasmic areas were evaluated using digital image analysis; the ratio of nuclear to cytoplasmic areas and nuclear roundness are presented. Results. The nuclear and cytoplasmic areas of the BD patients' cells were significantly smaller than those of the healthy controls' cells, while the nucleus-to-cytoplasm ratio and neutrophil infiltration rate did not differ significantly between the groups. However, the nuclear area, cytoplasmic area, nucleus-to-cytoplasm ratio, and nuclear roundness factor were significantly higher in patients without aphthae. The neutrophil infiltration rate did not differ significantly in patients with or without aphthae. Conclusion. Behcet's disease can produce cytomorphometric changes in buccal cells that are detectable by exfoliative cytology and cytomorphometric analysis techniques.
Açıklama
[dc.description]
WOS: 000373634600001
Açıklama
[dc.description]
PubMed: 27088074
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
2210-7177
ISSN
[dc.identifier.issn]
2210-7185
Dergi Adı
[dc.relation.journal]
ANALYTICAL CELLULAR PATHOLOGY
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1155/2016/6035801
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2335
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
14
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Şubat 2024 20:15
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Tıklayınız
nuclear patients significantly cytoplasmic cytomorphometric disease healthy buccal infiltration neutrophil analysis roundness differ nucleus-to-cytoplasm without aphthae Behcet controls techniques cytology exfoliative detectable changes higher produce Conclusion between groups However factor Background smaller gender-matched compare characteristics
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