Effect of dexmedetomidine on acute lung injury in experimental ischemia-reperfusion model

Purpose: Ischemia-reperfusion injury is one of the consequences of tourniquet application for extremity surgery. The aim of the study was to establish the effect of dexmedetomidine on the acute lung injury following lower extremity experimental ischemia-reperfusion model in rats. Methods: Twenty-eight Wistar-Albino breed rats were recruited after Ethics Committee approval and allocated into 4 groups, each with 7 subjects. Group 1 (SHAM) received only anesthesia. Group 2 (IR) had experienced 3 h of ischemia and 3 h of reperfusion using left lower extremity tourniquet after anesthesia application. Groups 3 (D-50) and 4 (D-100) had undergone the same procedures as in the Group 2, except for receiving 50 and 100 mg.kg(-1), respectively, dexmedetomidine intraperitoneally 1 h before the tourniquet release. Blood samples were obtained for the analysis of tumor necrosing factor-alpha and interleukin-6. Pulmonary tissue samples were obtained for histological analysis. Results: No significant difference regarding blood tumor necrosing factor -alpha and interleukin-6 values was found among the groups, whereas pulmonary tissue injury scores revealed significant difference. Histological scores obtained from the Group 2 were significantly higher from those in the Groups 1, 3 and 4 with p-values 0.001 for each comparison. Moreover, Group 1 scores were found to be significantly lower than those in the Groups 3 and 4 with p-values 0.001 and 0.011, respectively. No significant difference was observed between the Groups 3 and 4. Conclusion: Dexmedetomidine is effective in reduction of the experimental ischemia-reperfusion induced pulmonary tissue injury in rats, formed by extremity tourniquet application. (C) 2016 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda.

Yazar Kucukebe, Omer Burak
Ozzeybek, Deniz
Abdullayev, Ruslan
Ustaoglu, Adil
Tekmen, Isli
Kume, Tuncay
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2441
Tek Biçim Adres 10.1016/j.bjan.2016.09.004
Konu Başlıkları Experimental
Dexmedetornidirie
Reperfusion injury
Acute lung injury
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı REVISTA BRASILEIRA DE ANESTESIOLOGIA
Dergi Cilt Bilgisi 67
Dergi Sayısı 2
Sayfalar 139 - 146
Yayın Yılı 2017
Eser Adı
[dc.title]
Effect of dexmedetomidine on acute lung injury in experimental ischemia-reperfusion model
Yazar
[dc.contributor.author]
Kucukebe, Omer Burak
Yazar
[dc.contributor.author]
Ozzeybek, Deniz
Yazar
[dc.contributor.author]
Abdullayev, Ruslan
Yazar
[dc.contributor.author]
Ustaoglu, Adil
Yazar
[dc.contributor.author]
Tekmen, Isli
Yazar
[dc.contributor.author]
Kume, Tuncay
Yayın Yılı
[dc.date.issued]
2017
Yayıncı
[dc.publisher]
ELSEVIER SCIENCE INC
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Purpose: Ischemia-reperfusion injury is one of the consequences of tourniquet application for extremity surgery. The aim of the study was to establish the effect of dexmedetomidine on the acute lung injury following lower extremity experimental ischemia-reperfusion model in rats. Methods: Twenty-eight Wistar-Albino breed rats were recruited after Ethics Committee approval and allocated into 4 groups, each with 7 subjects. Group 1 (SHAM) received only anesthesia. Group 2 (IR) had experienced 3 h of ischemia and 3 h of reperfusion using left lower extremity tourniquet after anesthesia application. Groups 3 (D-50) and 4 (D-100) had undergone the same procedures as in the Group 2, except for receiving 50 and 100 mg.kg(-1), respectively, dexmedetomidine intraperitoneally 1 h before the tourniquet release. Blood samples were obtained for the analysis of tumor necrosing factor-alpha and interleukin-6. Pulmonary tissue samples were obtained for histological analysis. Results: No significant difference regarding blood tumor necrosing factor -alpha and interleukin-6 values was found among the groups, whereas pulmonary tissue injury scores revealed significant difference. Histological scores obtained from the Group 2 were significantly higher from those in the Groups 1, 3 and 4 with p-values 0.001 for each comparison. Moreover, Group 1 scores were found to be significantly lower than those in the Groups 3 and 4 with p-values 0.001 and 0.011, respectively. No significant difference was observed between the Groups 3 and 4. Conclusion: Dexmedetomidine is effective in reduction of the experimental ischemia-reperfusion induced pulmonary tissue injury in rats, formed by extremity tourniquet application. (C) 2016 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda.
Açıklama
[dc.description]
WOS: 000397558100004
Açıklama
[dc.description]
PubMed: 27692370
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
por
Konu Başlıkları
[dc.subject]
Experimental
Konu Başlıkları
[dc.subject]
Dexmedetornidirie
Konu Başlıkları
[dc.subject]
Reperfusion injury
Konu Başlıkları
[dc.subject]
Acute lung injury
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0034-7094
ISSN
[dc.identifier.issn]
1806-907X
İlk Sayfa Sayısı
[dc.identifier.startpage]
139
Son Sayfa Sayısı
[dc.identifier.endpage]
146
Dergi Adı
[dc.relation.journal]
REVISTA BRASILEIRA DE ANESTESIOLOGIA
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
67
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.bjan.2016.09.004
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2441
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
19
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 20:46
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Tıklayınız
Groups tourniquet extremity injury scores significant difference tissue application obtained p-values anesthesia pulmonary significantly groups respectively samples analysis necrosing interleukin-6 ischemia-reperfusion experimental dexmedetomidine observed Anestesiologia factor regarding Brasileira histological Results values Published Pulmonary Elsevier Editora
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