The role of patient's systemic characteristics and plateletcrit in developing toxic anterior segment syndrome after uneventful phaco surgery: A case-control study

Purpose To compare the systemic and ocular characteristics and laboratory findings of patients developing toxic anterior segment syndrome (TASS) after uneventful phaco surgery with unaffected subjects undergoing the same surgery in the same session. Design A retrospective case-control study. Methods The study group consisted of 26 eyes of 26 patients who underwent uneventful phaco surgery and who went on to develop TASS, while the control group included 39 subjects who had routine phaco surgery in the same session by the same surgeon. The sterilization stages of reusable instruments, disposable instruments, and compositions were recorded. The preoperative systemic diseases, complete blood count parameters, glycosylated hemoglobin (HbA1c), biochemical parameters, thyroid hormone profiles, and the surgical features were compared between the two groups. Results Type 2 diabetes mellitus (DM), systemic hypertension (HT), hyperlipidemia, chronic ischaemic heart disease, and chronic renal failure were significantly more common in the TASS group (p < 0.05). Proliferative diabetic retinopathy was also more frequent in the TASS group (p = 0.003). Mean HbA1c% values, white blood cell count, neutrophil/lymphocyte ratio, platelet counts, platelet distribution width, and plateletcrit parameters were significantly higher in the TASS group (p < 0.05). Multivariate logistic regression analysis revealed that a high plateletcrit level (p = 0.001, odds ratio [95% CI]; 22.27 [3.36-147.76]) and systemic HT (p = 0.044, odds ratio [95% CI]; 7.13 [1.05-48.12]) are independently associated with the development of TASS. Conclusion Although TASS may arise as a result of insufficient sterilization of instruments or intraocular solutions, patient factors may also contribute to its development. Systemic vascular disorders such as uncontrolled type 2 DM, systemic hypertension, and hyperlipidemia may increase the risk of TASS after uneventful phaco surgery. Abnormal parameters associated with systemic inflammation, such as higher plateletcrit level, may facilitate the development of TASS. These findings may be a predicting factor of TASS development for uneventful cataract surgeries.

Yazar Yazgan, Serpil
Celik, Ugur
Ayar, Orhan
Ugurbas, Suat Hayri
Celik, Burcu
Akdemir, Mehmet Orcun
Ugurbas, Silay Canturk
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3667
Tek Biçim Adres 10.1007/s10792-016-0418-x
Konu Başlıkları Plateletcrit
Systemic diseases
Toxic anterior segment syndrome
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı INTERNATIONAL OPHTHALMOLOGY
Dergi Cilt Bilgisi 38
Dergi Sayısı 1
Sayfalar 43 - 52
Yayın Yılı 2018
Eser Adı
[dc.title]
The role of patient's systemic characteristics and plateletcrit in developing toxic anterior segment syndrome after uneventful phaco surgery: A case-control study
Yazar
[dc.contributor.author]
Yazgan, Serpil
Yazar
[dc.contributor.author]
Celik, Ugur
Yazar
[dc.contributor.author]
Ayar, Orhan
Yazar
[dc.contributor.author]
Ugurbas, Suat Hayri
Yazar
[dc.contributor.author]
Celik, Burcu
Yazar
[dc.contributor.author]
Akdemir, Mehmet Orcun
Yazar
[dc.contributor.author]
Ugurbas, Silay Canturk
Yayın Yılı
[dc.date.issued]
2018
Yayıncı
[dc.publisher]
SPRINGER
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Purpose To compare the systemic and ocular characteristics and laboratory findings of patients developing toxic anterior segment syndrome (TASS) after uneventful phaco surgery with unaffected subjects undergoing the same surgery in the same session. Design A retrospective case-control study. Methods The study group consisted of 26 eyes of 26 patients who underwent uneventful phaco surgery and who went on to develop TASS, while the control group included 39 subjects who had routine phaco surgery in the same session by the same surgeon. The sterilization stages of reusable instruments, disposable instruments, and compositions were recorded. The preoperative systemic diseases, complete blood count parameters, glycosylated hemoglobin (HbA1c), biochemical parameters, thyroid hormone profiles, and the surgical features were compared between the two groups. Results Type 2 diabetes mellitus (DM), systemic hypertension (HT), hyperlipidemia, chronic ischaemic heart disease, and chronic renal failure were significantly more common in the TASS group (p < 0.05). Proliferative diabetic retinopathy was also more frequent in the TASS group (p = 0.003). Mean HbA1c% values, white blood cell count, neutrophil/lymphocyte ratio, platelet counts, platelet distribution width, and plateletcrit parameters were significantly higher in the TASS group (p < 0.05). Multivariate logistic regression analysis revealed that a high plateletcrit level (p = 0.001, odds ratio [95% CI]; 22.27 [3.36-147.76]) and systemic HT (p = 0.044, odds ratio [95% CI]; 7.13 [1.05-48.12]) are independently associated with the development of TASS. Conclusion Although TASS may arise as a result of insufficient sterilization of instruments or intraocular solutions, patient factors may also contribute to its development. Systemic vascular disorders such as uncontrolled type 2 DM, systemic hypertension, and hyperlipidemia may increase the risk of TASS after uneventful phaco surgery. Abnormal parameters associated with systemic inflammation, such as higher plateletcrit level, may facilitate the development of TASS. These findings may be a predicting factor of TASS development for uneventful cataract surgeries.
Açıklama
[dc.description]
WOS: 000428760800008
Açıklama
[dc.description]
PubMed: 28130690
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Plateletcrit
Konu Başlıkları
[dc.subject]
Systemic diseases
Konu Başlıkları
[dc.subject]
Toxic anterior segment syndrome
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0165-5701
ISSN
[dc.identifier.issn]
1573-2630
İlk Sayfa Sayısı
[dc.identifier.startpage]
43
Son Sayfa Sayısı
[dc.identifier.endpage]
52
Dergi Adı
[dc.relation.journal]
INTERNATIONAL OPHTHALMOLOGY
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
38
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1007/s10792-016-0418-x
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3667
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
18
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 09:10
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Tıklayınız
systemic surgery uneventful parameters development plateletcrit instruments subjects sterilization associated hypertension findings patients hyperlipidemia chronic platelet significantly session higher Purpose revealed analysis regression logistic Multivariate distribution counts neutrophil/lymphocyte 36-147 Although inflammation disorders uncontrolled increase Abnormal
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