Effects of nitric oxide donor and inhibitor on prostaglandin E-2-like activity, malondialdehyde and reduced glutathione levels after skeletal muscle ischemia-reperfusion

Oxygen free radicals are implicated in the pathophysiology of ischemia-reperfusion (I/R) injury in skeletal muscle. Nitric oxide (NO) and prostaglandin E-2 (PGE(2)) are important regulators of the microcirculation in skeletal muscle. The effects of L-arginine, substrate for NO, and NG-nitro L-arginine methyl ester (L-NAME) on PGE2 synthesis, lipid peroxidation and reduced glutathione (GSH) levels was investigated in the rat gastrocnemius muscle after 3 h of reperfusion following 2 h of ischemia. Lipid peroxidation and GSH levels showed a non-significant changes in the I/R groups compared to the control group. According to these results, it can be assumed that skeletal muscle can resist 2 h of ischemia followed by 3 h of reperfusion-induced oxidative stress. PGE(2)-like activity in the gastrocnemius muscle increased in the L-NAME treated and I/R groups. L-arginine administration reversed the increase in PGE2-like activity of reperfused skeletal muscle. These findings support the conclusion that endothelium-derived PGE2 synthesis increases during reperfusion and suggest that PGE2 may have a protective role in the maintenance of endothelial function. (C) 2001 Harcourt Publishers Ltd.

Yazar Sayan, H
Babul, A
Ugurlu, B
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2499
Tek Biçim Adres 10.1054/plef.2001.0308
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Dergi Cilt Bilgisi 65
Dergi Sayısı 4
Sayfalar 179 - 183
Yayın Yılı 2001
Eser Adı
[dc.title]
Effects of nitric oxide donor and inhibitor on prostaglandin E-2-like activity, malondialdehyde and reduced glutathione levels after skeletal muscle ischemia-reperfusion
Yazar
[dc.contributor.author]
Sayan, H
Yazar
[dc.contributor.author]
Babul, A
Yazar
[dc.contributor.author]
Ugurlu, B
Yayın Yılı
[dc.date.issued]
2001
Yayıncı
[dc.publisher]
CHURCHILL LIVINGSTONE
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Oxygen free radicals are implicated in the pathophysiology of ischemia-reperfusion (I/R) injury in skeletal muscle. Nitric oxide (NO) and prostaglandin E-2 (PGE(2)) are important regulators of the microcirculation in skeletal muscle. The effects of L-arginine, substrate for NO, and NG-nitro L-arginine methyl ester (L-NAME) on PGE2 synthesis, lipid peroxidation and reduced glutathione (GSH) levels was investigated in the rat gastrocnemius muscle after 3 h of reperfusion following 2 h of ischemia. Lipid peroxidation and GSH levels showed a non-significant changes in the I/R groups compared to the control group. According to these results, it can be assumed that skeletal muscle can resist 2 h of ischemia followed by 3 h of reperfusion-induced oxidative stress. PGE(2)-like activity in the gastrocnemius muscle increased in the L-NAME treated and I/R groups. L-arginine administration reversed the increase in PGE2-like activity of reperfused skeletal muscle. These findings support the conclusion that endothelium-derived PGE2 synthesis increases during reperfusion and suggest that PGE2 may have a protective role in the maintenance of endothelial function. (C) 2001 Harcourt Publishers Ltd.
Açıklama
[dc.description]
WOS: 000172741800001
Açıklama
[dc.description]
PubMed: 11728169
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0952-3278
İlk Sayfa Sayısı
[dc.identifier.startpage]
179
Son Sayfa Sayısı
[dc.identifier.endpage]
183
Dergi Adı
[dc.relation.journal]
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
65
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1054/plef.2001.0308
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2499
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
11
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
06 Şubat 2024 12:44
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Tıklayınız
muscle skeletal L-arginine levels reperfusion ischemia activity peroxidation gastrocnemius groups synthesis PGE(2)-like Oxygen stress increased resist oxidative reperfusion-induced followed assumed L-NAME increase treated Publishers Harcourt function endothelial maintenance protective suggest administration during increases endothelium-derived conclusion
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