The Effect of Cannabidiol on Ischemia/Reperfusion-Induced Ventricular Arrhythmias: The Role of Adenosine A(1) Receptors

Cannabidiol (CBD) is a nonpsychoactive phytocannabinoid with anti-inflammatory activity mediated by enhancing adenosine signaling. As the adenosine A(1) receptor activation confers protection against ischemia/reperfusion (I/R)-induced ventricular arrhythmias, we hypothesized that CBD may have antiarrhythmic effect through the activation of adenosine A(1) receptor. Cannabidiol has recently been shown to suppress ischemia-induced ventricular arrhythmias. We aimed to research the effect of CBD on the incidence and the duration of I/R-induced ventricular arrhythmias and to investigate the role of adenosine A(1) receptor activation in the possible antiarrhythmic effect of CBD. Myocardial ischemia and reperfusion was induced in anesthetized male rats by ligating the left anterior descending coronary artery for 6 minutes and by loosening the bond at the coronary artery, respectively. Cannabidiol alone was given in a dose of 50 mu g/kg, 10 minutes prior to coronary artery occlusion and coadministrated with adenosine A(1) receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) in a dose of 100 mu g/kg, 15 minutes prior to coronary artery occlusion to investigate whether the antiarrhythmic effect of CBD is modified by the activation of adenosine A(1) receptors. The experimental groups were as follows: (1) vehicle control (n = 10), (2) CBD (n = 9), (3) DPCPX (n = 7), and (4) CBD + DPCPX group (n = 7). Cannabidiol treatment significantly decreased the incidence and the duration of ventricular tachycardia, total length of arrhythmias, and the arrhythmia scores compared to control during the reperfusion period. The DPCPX treatment alone did not affect the incidence and the duration of any type of arrhythmias. However, DPCPX aborted the antiarrhythmic effect of CBD when it was combined with it. The present results demonstrated that CBD has an antiarrhythmic effect against I/R-induced arrhythmias, and the antiarrhythmic effect of CBD may be mediated through the activation of adenosine A(1) receptor.

Dergi Adı JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
Dergi Cilt Bilgisi 20
Dergi Sayısı 1
Sayfalar 76 - 83
Yayın Yılı 2015
Eser Adı
[dc.title]
The Effect of Cannabidiol on Ischemia/Reperfusion-Induced Ventricular Arrhythmias: The Role of Adenosine A(1) Receptors
Yazar
[dc.contributor.author]
Gonca, Ersoz
Yazar
[dc.contributor.author]
Darici, Faruk
Yayın Yılı
[dc.date.issued]
2015
Yayıncı
[dc.publisher]
SAGE PUBLICATIONS INC
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Cannabidiol (CBD) is a nonpsychoactive phytocannabinoid with anti-inflammatory activity mediated by enhancing adenosine signaling. As the adenosine A(1) receptor activation confers protection against ischemia/reperfusion (I/R)-induced ventricular arrhythmias, we hypothesized that CBD may have antiarrhythmic effect through the activation of adenosine A(1) receptor. Cannabidiol has recently been shown to suppress ischemia-induced ventricular arrhythmias. We aimed to research the effect of CBD on the incidence and the duration of I/R-induced ventricular arrhythmias and to investigate the role of adenosine A(1) receptor activation in the possible antiarrhythmic effect of CBD. Myocardial ischemia and reperfusion was induced in anesthetized male rats by ligating the left anterior descending coronary artery for 6 minutes and by loosening the bond at the coronary artery, respectively. Cannabidiol alone was given in a dose of 50 mu g/kg, 10 minutes prior to coronary artery occlusion and coadministrated with adenosine A(1) receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) in a dose of 100 mu g/kg, 15 minutes prior to coronary artery occlusion to investigate whether the antiarrhythmic effect of CBD is modified by the activation of adenosine A(1) receptors. The experimental groups were as follows: (1) vehicle control (n = 10), (2) CBD (n = 9), (3) DPCPX (n = 7), and (4) CBD + DPCPX group (n = 7). Cannabidiol treatment significantly decreased the incidence and the duration of ventricular tachycardia, total length of arrhythmias, and the arrhythmia scores compared to control during the reperfusion period. The DPCPX treatment alone did not affect the incidence and the duration of any type of arrhythmias. However, DPCPX aborted the antiarrhythmic effect of CBD when it was combined with it. The present results demonstrated that CBD has an antiarrhythmic effect against I/R-induced arrhythmias, and the antiarrhythmic effect of CBD may be mediated through the activation of adenosine A(1) receptor.
Açıklama
[dc.description]
WOS: 000346058800009
Açıklama
[dc.description]
PubMed: 24853683
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
cannabidiol
Konu Başlıkları
[dc.subject]
ischemia-reperfusion arrhythmias
Konu Başlıkları
[dc.subject]
anesthetized rats
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1074-2484
ISSN
[dc.identifier.issn]
1940-4034
Sponsor YAYINCI
[dc.description.sponsorship]
Bulent Ecevit University (BAP)Bulent Ecevit University [2013-84906727-10]
Sponsor YAYINCI
[dc.description.sponsorship]
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Research fund grant from Bulent Ecevit University (BAP No: 2013-84906727-10).
İlk Sayfa Sayısı
[dc.identifier.startpage]
76
Son Sayfa Sayısı
[dc.identifier.endpage]
83
Dergi Adı
[dc.relation.journal]
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
20
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1177/1074248414532013
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3492
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
4
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
12 Aralık 2023 12:59
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Tıklayınız
effect adenosine arrhythmias antiarrhythmic receptor activation ventricular artery coronary Cannabidiol duration incidence minutes against reperfusion treatment investigate I/R-induced control mediated through occlusion groups follows modified receptors vehicle experimental length affect demonstrated results present combined aborted
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