Gastroprotective activity of Nigella sativa L oil and its constituent, thymoquinone against acute alcohol-induced gastric mucosal injury in rats

AIM: To evaluate the role of reactive oxygen species in the pathogenesis of acute ethanol-induced gastric mucosal lesions and the effect of Nigella sativa L oil (NS) and its constituent thymoquinone (TQ) in an experimental model. METHODS: Male Wistar albino rats were assigned into 4 groups. Control group was given physiologic saline orally (10 mL/kg body weight) as the vehicle (gavage); ethanol group was administrated 1 mL (per rat) absolute alcohol by gavage; the third and fourth groups were given NS (10 mL/kg body weight) and TQ (10 mg/kg body weight p.o) respectively 1 h prior to alcohol intake. One hour after ethanol administration, stomach tissues were excised for macroscopic examination and biochemical analysis. RESULTS: NS and TQ could protect gastric mucosa against the injurious effect of absolute alcohol and promote ulcer healing as evidenced from the ulcer index (UI) values. NS prevented alcohol-induced increase in thiobarbituric acid-reactive substances (TBARS), an index of lipid peroxidation. NS also increased gastric glutathione content (GSH), enzymatic activities of gastric superoxide dismutase (SOD) and glutathione-S-transferase (GST). Likewise, TQ protected against the ulcerating effect of alcohol and mitigated most of the biochemical adverse effects induced by alcohol in gastric mucosa, but to a lesser extent than NS. Neither NS nor TQ affected catalase activity in gastric tissue. CONCLUSION: Both NS and TQ, particularly NS can partly protect gastric mucosa from acute alcohol-induced mucosal injury, and these gastroprotective effects might be induced, at least partly by their radical scavenging activity. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.

Yazar Kanter, Mehmet
Demir, Halit
Karakaya, Cengiz
Ozbek, Hanefi
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2672
Tek Biçim Adres 10.3748/wjg.v11.i42.6662
Konu Başlıkları Nigella sativa
Thymoquinone
Ulcer
Anti-oxidant
Rat
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı WORLD JOURNAL OF GASTROENTEROLOGY
Dergi Cilt Bilgisi 11
Dergi Sayısı 42
Sayfalar 6662 - 6666
Yayın Yılı 2005
Eser Adı
[dc.title]
Gastroprotective activity of Nigella sativa L oil and its constituent, thymoquinone against acute alcohol-induced gastric mucosal injury in rats
Yazar
[dc.contributor.author]
Kanter, Mehmet
Yazar
[dc.contributor.author]
Demir, Halit
Yazar
[dc.contributor.author]
Karakaya, Cengiz
Yazar
[dc.contributor.author]
Ozbek, Hanefi
Yayın Yılı
[dc.date.issued]
2005
Yayıncı
[dc.publisher]
BAISHIDENG PUBLISHING GROUP INC
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
AIM: To evaluate the role of reactive oxygen species in the pathogenesis of acute ethanol-induced gastric mucosal lesions and the effect of Nigella sativa L oil (NS) and its constituent thymoquinone (TQ) in an experimental model. METHODS: Male Wistar albino rats were assigned into 4 groups. Control group was given physiologic saline orally (10 mL/kg body weight) as the vehicle (gavage); ethanol group was administrated 1 mL (per rat) absolute alcohol by gavage; the third and fourth groups were given NS (10 mL/kg body weight) and TQ (10 mg/kg body weight p.o) respectively 1 h prior to alcohol intake. One hour after ethanol administration, stomach tissues were excised for macroscopic examination and biochemical analysis. RESULTS: NS and TQ could protect gastric mucosa against the injurious effect of absolute alcohol and promote ulcer healing as evidenced from the ulcer index (UI) values. NS prevented alcohol-induced increase in thiobarbituric acid-reactive substances (TBARS), an index of lipid peroxidation. NS also increased gastric glutathione content (GSH), enzymatic activities of gastric superoxide dismutase (SOD) and glutathione-S-transferase (GST). Likewise, TQ protected against the ulcerating effect of alcohol and mitigated most of the biochemical adverse effects induced by alcohol in gastric mucosa, but to a lesser extent than NS. Neither NS nor TQ affected catalase activity in gastric tissue. CONCLUSION: Both NS and TQ, particularly NS can partly protect gastric mucosa from acute alcohol-induced mucosal injury, and these gastroprotective effects might be induced, at least partly by their radical scavenging activity. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.
Açıklama
[dc.description]
WOS: 000208224700016
Açıklama
[dc.description]
PubMed: 16425361
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Nigella sativa
Konu Başlıkları
[dc.subject]
Thymoquinone
Konu Başlıkları
[dc.subject]
Ulcer
Konu Başlıkları
[dc.subject]
Anti-oxidant
Konu Başlıkları
[dc.subject]
Rat
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1007-9327
ISSN
[dc.identifier.issn]
2219-2840
İlk Sayfa Sayısı
[dc.identifier.startpage]
6662
Son Sayfa Sayısı
[dc.identifier.endpage]
6666
Dergi Adı
[dc.relation.journal]
WORLD JOURNAL OF GASTROENTEROLOGY
Dergi Sayısı
[dc.identifier.issue]
42
Dergi Cilt Bilgisi
[dc.identifier.volume]
11
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.3748/wjg.v11.i42.6662
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2672
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
14
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
17 Nisan 2024 15:22
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Tıklayınız
gastric alcohol effect mucosa groups ethanol induced effects absolute biochemical protect against alcohol-induced activity weight) mucosal partly CONCLUSION increased glutathione content superoxide enzymatic activities dismutase glutathione-S-transferase peroxidation Likewise (TBARS) substances acid-reactive Elsevier thiobarbituric increase rights
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