The Elevated Soluble ST2 Predicts No-Ref ow Phenomenon in ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Aim: The primary percutaneous procedure resulted in a significant improvement in the prognosis of myocardial infarction. However, no-reflow phenomenon restrains this benefit of the process. There are studies suggesting that soluble suppression of tumorigenicity (sST2) can be valuable in the diagnosis and progression of heart failure and myocardial infarction. In this study, we aimed to investigate the effect of sST2 on no-reflow phenomenon in ST-elevated myocardial infarction (STEMI). Method: This study included 379 patients (258 men; mean age, 60 +/- 11 years) who underwent primary percutaneous treatment for STEMI. sST2 levels were measured from blood samples taken at admission. Patients were divided into two groups according to Thrombolysis in Myocardial Infarction(TIMI) flow grade: group 1 consists of TIMI 0,1,2, accepted as no-reflow, and group 2 consists of TIMI 3, accepted as reflow. Results: No-reflow phenomenon occurred in 60 patients (15.8%). The sST2 level was higher in the no-reflow group (14.2 +/- 4.6 vs. 11.3 +/- 5.0, p=0.003). Moreover, regression analysis indicated that diabetes mellitus, lower systolic blood pressure, multivessel vascular disease, high plaque burden, and grade 0 initial TIMI flow rate were other independent predictors of the no-reflow phenomenon in our study. Besides, when the patients were divided into high and low sST2 groups according to the cut-off value from the Receiver operating characteristics analysis, being in the high sST2 group was associated with 2.7 times increased odds for no-reflow than being in the low sST2 group. Conclusion: sST2 is one of the independent predictors of the no-reflow phenomenon in STEMI patients undergoing primary percutaneous coronary intervention.

Yazar Somuncu, Mustafa Umut
Akgun, Tunahan
Cakir, Mustafa Ozan
Akgul, Ferit
Serbest, Nail Guven
Karakurt, Huseyin
Can, Murat
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3576
Tek Biçim Adres 10.5551/jat.48413
Konu Başlıkları Myocardial infarction
soluble ST2
No-reflow-phenomenon
Inflammation
In-hospital mortality
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
Dergi Cilt Bilgisi 26
Dergi Sayısı 11
Sayfalar 970 - 978
Yayın Yılı 2019
Eser Adı
[dc.title]
The Elevated Soluble ST2 Predicts No-Ref ow Phenomenon in ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Yazar
[dc.contributor.author]
Somuncu, Mustafa Umut
Yazar
[dc.contributor.author]
Akgun, Tunahan
Yazar
[dc.contributor.author]
Cakir, Mustafa Ozan
Yazar
[dc.contributor.author]
Akgul, Ferit
Yazar
[dc.contributor.author]
Serbest, Nail Guven
Yazar
[dc.contributor.author]
Karakurt, Huseyin
Yazar
[dc.contributor.author]
Can, Murat
Yayın Yılı
[dc.date.issued]
2019
Yayıncı
[dc.publisher]
JAPAN ATHEROSCLEROSIS SOC
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Aim: The primary percutaneous procedure resulted in a significant improvement in the prognosis of myocardial infarction. However, no-reflow phenomenon restrains this benefit of the process. There are studies suggesting that soluble suppression of tumorigenicity (sST2) can be valuable in the diagnosis and progression of heart failure and myocardial infarction. In this study, we aimed to investigate the effect of sST2 on no-reflow phenomenon in ST-elevated myocardial infarction (STEMI). Method: This study included 379 patients (258 men; mean age, 60 +/- 11 years) who underwent primary percutaneous treatment for STEMI. sST2 levels were measured from blood samples taken at admission. Patients were divided into two groups according to Thrombolysis in Myocardial Infarction(TIMI) flow grade: group 1 consists of TIMI 0,1,2, accepted as no-reflow, and group 2 consists of TIMI 3, accepted as reflow. Results: No-reflow phenomenon occurred in 60 patients (15.8%). The sST2 level was higher in the no-reflow group (14.2 +/- 4.6 vs. 11.3 +/- 5.0, p=0.003). Moreover, regression analysis indicated that diabetes mellitus, lower systolic blood pressure, multivessel vascular disease, high plaque burden, and grade 0 initial TIMI flow rate were other independent predictors of the no-reflow phenomenon in our study. Besides, when the patients were divided into high and low sST2 groups according to the cut-off value from the Receiver operating characteristics analysis, being in the high sST2 group was associated with 2.7 times increased odds for no-reflow than being in the low sST2 group. Conclusion: sST2 is one of the independent predictors of the no-reflow phenomenon in STEMI patients undergoing primary percutaneous coronary intervention.
Açıklama
[dc.description]
WOS: 000494355200004
Açıklama
[dc.description]
PubMed: 30996145
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Myocardial infarction
Konu Başlıkları
[dc.subject]
soluble ST2
Konu Başlıkları
[dc.subject]
No-reflow-phenomenon
Konu Başlıkları
[dc.subject]
Inflammation
Konu Başlıkları
[dc.subject]
In-hospital mortality
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1340-3478
ISSN
[dc.identifier.issn]
1880-3873
İlk Sayfa Sayısı
[dc.identifier.startpage]
970
Son Sayfa Sayısı
[dc.identifier.endpage]
978
Dergi Adı
[dc.relation.journal]
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
Dergi Sayısı
[dc.identifier.issue]
11
Dergi Cilt Bilgisi
[dc.identifier.volume]
26
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.5551/jat.48413
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3576
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
16
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 11:32
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no-reflow phenomenon patients infarction myocardial percutaneous primary analysis divided groups according consists accepted independent predictors higher associated increased Conclusion undergoing coronary intervention occurred mellitus initial burden plaque No-reflow vascular multivessel pressure systolic Besides diabetes characteristics
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