SOMATOSENSORY EVOKED POTENTIALS OF HAND MUSCLES IN STROKE AND THEIR MODIFICATION BY BOTULINUM TOXIN: A PRELIMINARY STUDY

Objective: To determine the effect of botulinum toxin A on spasticity and somatosensory evoked potentials of hand muscles in patients who have undergone cerebrovascular accident. Design: Preliminary, prospective, before-after study design. Patients: Six subjects prospectively followed after application of botulinum toxin A in the rehabilitation department of a university hospital. Methods: All patients underwent botulinum toxin A injection to the upper extremity muscles in varying combinations and carried out a home-based exercise programme. Primary outcome measure was median somatosensory evoked potential of hand muscles (N20). Secondary outcome measures were: spasticity assessed clinically by Modified Ashworth Scales (MAS); functional ability analysis assessed by Physician's Rating Scale (PRS); and functional difficulties reported by patients or their care-givers by patient disability and care-giver burden rating scale (PD & CBRS). Results: MAS, PRS and PD & CBRS improved with botulinum toxin A treatment. In the affected limb, N20 potentials were impaired compared with those in the unaffected side. With botulinum toxin A treatment, although improvement in overall N20-P25 amplitudes was significant, as a result of limited sample size, post hoc pair-wise comparisons with Bonferroni correction failed to yield any significant pairs. Conclusion: The improvement in the median somatosensory evoked potentials following botulinum toxin A treatment suggests that central somatosensory patterns in hemiplegia can be modified by peripheral inputs.

Yazar Basaran, Aynur
Emre, Ufuk
Karadavut, Kiymet Ikbal
Bulmus, Nercivan
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3345
Tek Biçim Adres 10.2340/16501977-0978
Konu Başlıkları stroke
spisticity
upper extremity
somatosensory evoked potentials
botulinum toxin
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı JOURNAL OF REHABILITATION MEDICINE
Dergi Cilt Bilgisi 44
Dergi Sayısı 7
Sayfalar 541 - 546
Yayın Yılı 2012
Eser Adı
[dc.title]
SOMATOSENSORY EVOKED POTENTIALS OF HAND MUSCLES IN STROKE AND THEIR MODIFICATION BY BOTULINUM TOXIN: A PRELIMINARY STUDY
Yazar
[dc.contributor.author]
Basaran, Aynur
Yazar
[dc.contributor.author]
Emre, Ufuk
Yazar
[dc.contributor.author]
Karadavut, Kiymet Ikbal
Yazar
[dc.contributor.author]
Bulmus, Nercivan
Yayın Yılı
[dc.date.issued]
2012
Yayıncı
[dc.publisher]
FOUNDATION REHABILITATION INFORMATION
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective: To determine the effect of botulinum toxin A on spasticity and somatosensory evoked potentials of hand muscles in patients who have undergone cerebrovascular accident. Design: Preliminary, prospective, before-after study design. Patients: Six subjects prospectively followed after application of botulinum toxin A in the rehabilitation department of a university hospital. Methods: All patients underwent botulinum toxin A injection to the upper extremity muscles in varying combinations and carried out a home-based exercise programme. Primary outcome measure was median somatosensory evoked potential of hand muscles (N20). Secondary outcome measures were: spasticity assessed clinically by Modified Ashworth Scales (MAS); functional ability analysis assessed by Physician's Rating Scale (PRS); and functional difficulties reported by patients or their care-givers by patient disability and care-giver burden rating scale (PD & CBRS). Results: MAS, PRS and PD & CBRS improved with botulinum toxin A treatment. In the affected limb, N20 potentials were impaired compared with those in the unaffected side. With botulinum toxin A treatment, although improvement in overall N20-P25 amplitudes was significant, as a result of limited sample size, post hoc pair-wise comparisons with Bonferroni correction failed to yield any significant pairs. Conclusion: The improvement in the median somatosensory evoked potentials following botulinum toxin A treatment suggests that central somatosensory patterns in hemiplegia can be modified by peripheral inputs.
Açıklama
[dc.description]
WOS: 000305814900004
Açıklama
[dc.description]
PubMed: 22674234
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
stroke
Konu Başlıkları
[dc.subject]
spisticity
Konu Başlıkları
[dc.subject]
upper extremity
Konu Başlıkları
[dc.subject]
somatosensory evoked potentials
Konu Başlıkları
[dc.subject]
botulinum toxin
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1650-1977
İlk Sayfa Sayısı
[dc.identifier.startpage]
541
Son Sayfa Sayısı
[dc.identifier.endpage]
546
Dergi Adı
[dc.relation.journal]
JOURNAL OF REHABILITATION MEDICINE
Dergi Sayısı
[dc.identifier.issue]
7
Dergi Cilt Bilgisi
[dc.identifier.volume]
44
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.2340/16501977-0978
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3345
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
7
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
05 Şubat 2024 11:23
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Tıklayınız
botulinum somatosensory evoked potentials muscles patients treatment outcome significant median assessed functional improvement spasticity improved unaffected care-giver burden compared impaired rating affected Results limited although inputs peripheral modified hemiplegia patterns central suggests following Conclusion overall
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