Effects of various anesthesia maintenance on serum levels of selenium, copper, zinc, iron and antioxidant capacity

Background and objectives: In this study, we aimed to investigate the effects of sevoflurane, Desflurane; desflurane and propofol maintenances on serum levels of selenium, copper, zinc, iron, malondialdehyde, and glutathion peroxidase measurements, and antioxidant capacity. Methods: 60 patients scheduled for unilateral lower extremity surgery which would be performed with tourniquet under general anesthesia were divided into three groups. Blood samples Antioxidant capacity were collected to determine the baseline serum levels of selenium, copper, zinc, iron, malondialdehyde and glutathion peroxidase. Anesthesia was induced using 2-2.5 mg kg(-1) propofol, 1 mg kg(-1) lidocaine and 0.6 mg kg(-1) rocuronium. In the maintenance of anesthesia, under carrier gas of 50:50% O-2:N2O 4 L min(-1), 1 MAC sevoflorane was administered to Group S and 1 MAC desflurane to Group D; and under carrier gas of 50:50% O-2:air 4 L min(-1) 6 mg kg h(-1) propofol and 1 mu g kg h(-1) fentanyl infusion were administered to Group P. At postoperative blood specimens were collected again. Results: It was observed that only in Group S and P, levels of MDA decreased at postoperative 48th hour; levels of glutathion peroxidase increased in comparison to the baseline values. Selenium levels decreased in Group S and Group P, zinc levels decreased in Group P, and iron levels decreased in all three groups, and copper levels did not change in any groups in the postoperative period. Conclusion: According to the markers of malondialdehyde and glutathion peroxidase, it was concluded that maintenance of general anesthesia using propofol and sevoflurane activated the antioxidant system against oxidative stress and using desflurane had no effects on oxidative stress and antioxidant system. (C) 2014 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.

Yazar Akin, Mehmet
Ayoglu, Hilal
Okyay, Dilek
Ayoglu, Ferruh
Gur, Abdullah
Can, Murat
Yurtlu, Serhan
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2518
Tek Biçim Adres 10.1016/j.bjane.2014.04.001
Konu Başlıkları Propofol
Desflurane
Sevoflurane
Selenium
Zinc
Antioxidant capacity
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı REVISTA BRASILEIRA DE ANESTESIOLOGIA
Dergi Cilt Bilgisi 65
Dergi Sayısı 1
Sayfalar 51 - 60
Yayın Yılı 2015
Eser Adı
[dc.title]
Effects of various anesthesia maintenance on serum levels of selenium, copper, zinc, iron and antioxidant capacity
Yazar
[dc.contributor.author]
Akin, Mehmet
Yazar
[dc.contributor.author]
Ayoglu, Hilal
Yazar
[dc.contributor.author]
Okyay, Dilek
Yazar
[dc.contributor.author]
Ayoglu, Ferruh
Yazar
[dc.contributor.author]
Gur, Abdullah
Yazar
[dc.contributor.author]
Can, Murat
Yazar
[dc.contributor.author]
Yurtlu, Serhan
Yayın Yılı
[dc.date.issued]
2015
Yayıncı
[dc.publisher]
ELSEVIER SCIENCE INC
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background and objectives: In this study, we aimed to investigate the effects of sevoflurane, Desflurane; desflurane and propofol maintenances on serum levels of selenium, copper, zinc, iron, malondialdehyde, and glutathion peroxidase measurements, and antioxidant capacity. Methods: 60 patients scheduled for unilateral lower extremity surgery which would be performed with tourniquet under general anesthesia were divided into three groups. Blood samples Antioxidant capacity were collected to determine the baseline serum levels of selenium, copper, zinc, iron, malondialdehyde and glutathion peroxidase. Anesthesia was induced using 2-2.5 mg kg(-1) propofol, 1 mg kg(-1) lidocaine and 0.6 mg kg(-1) rocuronium. In the maintenance of anesthesia, under carrier gas of 50:50% O-2:N2O 4 L min(-1), 1 MAC sevoflorane was administered to Group S and 1 MAC desflurane to Group D; and under carrier gas of 50:50% O-2:air 4 L min(-1) 6 mg kg h(-1) propofol and 1 mu g kg h(-1) fentanyl infusion were administered to Group P. At postoperative blood specimens were collected again. Results: It was observed that only in Group S and P, levels of MDA decreased at postoperative 48th hour; levels of glutathion peroxidase increased in comparison to the baseline values. Selenium levels decreased in Group S and Group P, zinc levels decreased in Group P, and iron levels decreased in all three groups, and copper levels did not change in any groups in the postoperative period. Conclusion: According to the markers of malondialdehyde and glutathion peroxidase, it was concluded that maintenance of general anesthesia using propofol and sevoflurane activated the antioxidant system against oxidative stress and using desflurane had no effects on oxidative stress and antioxidant system. (C) 2014 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.
Açıklama
[dc.description]
WOS: 000348246300009
Açıklama
[dc.description]
PubMed: 25497750
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Propofol
Konu Başlıkları
[dc.subject]
Desflurane
Konu Başlıkları
[dc.subject]
Sevoflurane
Konu Başlıkları
[dc.subject]
Selenium
Konu Başlıkları
[dc.subject]
Zinc
Konu Başlıkları
[dc.subject]
Antioxidant capacity
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0034-7094
ISSN
[dc.identifier.issn]
1806-907X
Sponsor YAYINCI
[dc.description.sponsorship]
Bulent Ecevit University Scientific Researches Projects Coordination UnitBulent Ecevit University
Sponsor YAYINCI
[dc.description.sponsorship]
This study was supported by Bulent Ecevit University Scientific Researches Projects Coordination Unit.
İlk Sayfa Sayısı
[dc.identifier.startpage]
51
Son Sayfa Sayısı
[dc.identifier.endpage]
60
Dergi Adı
[dc.relation.journal]
REVISTA BRASILEIRA DE ANESTESIOLOGIA
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
65
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.bjane.2014.04.001
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2518
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
19
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
10 Şubat 2024 18:01
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Tıklayınız
levels glutathion peroxidase propofol decreased kg(-1) antioxidant groups malondialdehyde copper desflurane postoperative anesthesia collected baseline administered min(-1) maintenance carrier general system selenium stress oxidative sevoflurane effects capacity Editora observed Anestesiologia reserved Published rights Elsevier Brasileira
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