Thiol/disulphide homeostasis in manic episode and remission phases of bipolar disorder

Purpose: Bipolar disorder (BD) is a chronical psychiatric disorder of which pathophysiology was demonstrated to be related with oxidative stress. Thiol-disulphide homeostasis is an indicator of oxidative balance. This study aims to investigate thiol-disulphide homeostasis in BD. Materials and methods: 27 patients in manic episode (MA), 29 patients in remission (RE) and 60 healthy participants (HC) were included to the study. Serum native thiol and total thiol levels were measured with a novel colorimetric, automated method. The disulphide levels and disulphide/native thiol ratios were also calculated from these measured parameters. Results: Native thiol levels and total thiol levels of both MA and RE groups were lower than HC. No significant difference detected between MA and RE in terms of native thiol levels and total thiol levels. Disulphide levels and disulphide/native thiol ratio was detected statistically similar between three groups. Conclusion: Our results support the oxidative imbalance theory in pathophysiology of BD. Further studies with larger sample sizes are needed for being able to understand these pathways in detail and use them as a target of treatment.

Yazar Yirun, Merve Cingi
Unal, Kubranur
Yirun, Onur
Kilic, Osman Hasan Tahsin
Erel, Ozcan
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3700
Tek Biçim Adres 10.1080/08039488.2018.1497200
Konu Başlıkları Affective disorder
oxidative stress
mood episode
oxidative markers
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı NORDIC JOURNAL OF PSYCHIATRY
Dergi Cilt Bilgisi 72
Dergi Sayısı 8
Sayfalar 572 - 577
Yayın Yılı 2018
Eser Adı
[dc.title]
Thiol/disulphide homeostasis in manic episode and remission phases of bipolar disorder
Yazar
[dc.contributor.author]
Yirun, Merve Cingi
Yazar
[dc.contributor.author]
Unal, Kubranur
Yazar
[dc.contributor.author]
Yirun, Onur
Yazar
[dc.contributor.author]
Kilic, Osman Hasan Tahsin
Yazar
[dc.contributor.author]
Erel, Ozcan
Yayın Yılı
[dc.date.issued]
2018
Yayıncı
[dc.publisher]
TAYLOR & FRANCIS LTD
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Purpose: Bipolar disorder (BD) is a chronical psychiatric disorder of which pathophysiology was demonstrated to be related with oxidative stress. Thiol-disulphide homeostasis is an indicator of oxidative balance. This study aims to investigate thiol-disulphide homeostasis in BD. Materials and methods: 27 patients in manic episode (MA), 29 patients in remission (RE) and 60 healthy participants (HC) were included to the study. Serum native thiol and total thiol levels were measured with a novel colorimetric, automated method. The disulphide levels and disulphide/native thiol ratios were also calculated from these measured parameters. Results: Native thiol levels and total thiol levels of both MA and RE groups were lower than HC. No significant difference detected between MA and RE in terms of native thiol levels and total thiol levels. Disulphide levels and disulphide/native thiol ratio was detected statistically similar between three groups. Conclusion: Our results support the oxidative imbalance theory in pathophysiology of BD. Further studies with larger sample sizes are needed for being able to understand these pathways in detail and use them as a target of treatment.
Açıklama
[dc.description]
WOS: 000457414200005
Açıklama
[dc.description]
PubMed: 30178694
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Affective disorder
Konu Başlıkları
[dc.subject]
oxidative stress
Konu Başlıkları
[dc.subject]
mood episode
Konu Başlıkları
[dc.subject]
oxidative markers
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0803-9488
ISSN
[dc.identifier.issn]
1502-4725
İlk Sayfa Sayısı
[dc.identifier.startpage]
572
Son Sayfa Sayısı
[dc.identifier.endpage]
577
Dergi Adı
[dc.relation.journal]
NORDIC JOURNAL OF PSYCHIATRY
Dergi Sayısı
[dc.identifier.issue]
8
Dergi Cilt Bilgisi
[dc.identifier.volume]
72
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1080/08039488.2018.1497200
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3700
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
16
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Şubat 2024 09:12
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Tıklayınız
levels oxidative between measured native homeostasis detected patients disulphide/native pathophysiology groups disorder Disulphide Purpose significant difference statistically theory similar needed treatment target detail pathways understand sample larger studies Further Native imbalance support results Conclusion colorimetric
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