The Use of Thiol/Disulfide as a Novel Marker in Premature Ovarian Failure

The study aimed to compare the dynamic thiol/disulfide homeostasis between patients with premature ovarian failure (POF) and healthy women. A total of 77 women, 40 POF and 37 healthy controls, were recruited from a university hospital between December 2013 and June 2015. Blood samples were taken from patients to evaluate follicle stimulating hormone (FSH), luteinizing hormone, estradiol and thiol/disulfide levels. A new, fully automated method was used to measure plasma thiol, total thiol and disulfide levels. Disulfide levels, disulfide/native thiol and disulfide/total thiol ratios were significantly increased, native thiol/total thiol levels were significantly decreased in POF patients compared to controls (p < 0.001). FSH was negatively correlated with native thiol and native thiol/total thiol levels and positively with disulfide, disulfide/native thiol, and disulfide/total thiol levels. This is the first study demonstrating the thiol/disulfide homeostasis in women with POF and may help us understanding the pathophysiology. (C) 2016 S. Karger AG, Basel

Yazar Isik, Hatice
Sahbaz, Ahmet
Timur, Hakan
Aynioglu, Oner
Mert, Sule Atalay
Balik, Ahmet Rifat
Erel, Ozcan
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3689
Tek Biçim Adres 10.1159/000445745
Konu Başlıkları Premature ovarian failure
Oxidative stress
Thiol
Disulfide
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı GYNECOLOGIC AND OBSTETRIC INVESTIGATION
Dergi Cilt Bilgisi 82
Dergi Sayısı 2
Sayfalar 113 - 118
Yayın Yılı 2017
Eser Adı
[dc.title]
The Use of Thiol/Disulfide as a Novel Marker in Premature Ovarian Failure
Yazar
[dc.contributor.author]
Isik, Hatice
Yazar
[dc.contributor.author]
Sahbaz, Ahmet
Yazar
[dc.contributor.author]
Timur, Hakan
Yazar
[dc.contributor.author]
Aynioglu, Oner
Yazar
[dc.contributor.author]
Mert, Sule Atalay
Yazar
[dc.contributor.author]
Balik, Ahmet Rifat
Yazar
[dc.contributor.author]
Erel, Ozcan
Yayın Yılı
[dc.date.issued]
2017
Yayıncı
[dc.publisher]
KARGER
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
The study aimed to compare the dynamic thiol/disulfide homeostasis between patients with premature ovarian failure (POF) and healthy women. A total of 77 women, 40 POF and 37 healthy controls, were recruited from a university hospital between December 2013 and June 2015. Blood samples were taken from patients to evaluate follicle stimulating hormone (FSH), luteinizing hormone, estradiol and thiol/disulfide levels. A new, fully automated method was used to measure plasma thiol, total thiol and disulfide levels. Disulfide levels, disulfide/native thiol and disulfide/total thiol ratios were significantly increased, native thiol/total thiol levels were significantly decreased in POF patients compared to controls (p < 0.001). FSH was negatively correlated with native thiol and native thiol/total thiol levels and positively with disulfide, disulfide/native thiol, and disulfide/total thiol levels. This is the first study demonstrating the thiol/disulfide homeostasis in women with POF and may help us understanding the pathophysiology. (C) 2016 S. Karger AG, Basel
Açıklama
[dc.description]
WOS: 000397417000002
Açıklama
[dc.description]
PubMed: 27064983
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Premature ovarian failure
Konu Başlıkları
[dc.subject]
Oxidative stress
Konu Başlıkları
[dc.subject]
Thiol
Konu Başlıkları
[dc.subject]
Disulfide
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0378-7346
ISSN
[dc.identifier.issn]
1423-002X
İlk Sayfa Sayısı
[dc.identifier.startpage]
113
Son Sayfa Sayısı
[dc.identifier.endpage]
118
Dergi Adı
[dc.relation.journal]
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
82
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1159/000445745
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3689
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
10
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
12 Aralık 2023 06:25
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Tıklayınız
levels patients native thiol/disulfide disulfide/total disulfide/native thiol/total hormone significantly controls disulfide between healthy homeostasis understanding pathophysiology ratios increased Karger Disulfide decreased compared negatively correlated positively demonstrating luteinizing plasma university recruited December failure ovarian premature dynamic
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