Prostate specific antigen levels after acute myocardial infarction

Prostate Specific Antigen (PSA), a member of kallikrein family, is a specific serine protease of prostatic tissue. In some case reports, changes in PSA levels after acute myocardial infarction (AMI) have been reported. In this study we evaluated variations in PSA levels post-AMI. Twenty-six male patients who had PSA levels within reference limits were included in the study. The diagnosis of AMI was confirmed by clinical findings, ECG (electrocardiogram) and cardiac marker studies. Serum total PSA (tPSA) and free PSA (fPSA) levels were measured at days 0 (day of admission), 1, 2 and 3 after AMI. PSA/albumin ratio was also calculated in order to evaluate the effect of dilution. A statistical analysis of the results of all patients revealed significant decrease in tPSA levels and tPSA/Albumin ratio at day 2 when compared to days 0 and 3, which showed a similar pattern. Changes of fPSA and fPSA/Albumin ratio according to days were not found significant. In only four patients we found increased levels of tPSA and increased fPSA levels in three of them. These patients displayed severe problems such as renal failure, cardiac failure, ventricular aneurysm and cerebral ischemia due to cardiac arrest. The lower tPSA levels on day 2 suggest that tPSA can be eliminated rapidly from the circulation on days 1 and 2, probably through the formation of complexes of tPSA with acute phase proteins.

Yazar Acikgoz, Serefden
Can, Murat
Dogan, Salt Mesut
Mungan, Gorkem
Aydin, Mustafa
Kelek, Serdar
Sumbuloglu, Vildan
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3179
Konu Başlıkları acute myocardial infarction
total prostate specific antigen
free prostate specific antigen
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı ACTA BIOCHIMICA POLONICA
Dergi Cilt Bilgisi 58
Dergi Sayısı 4
Sayfalar 541 - 545
Yayın Yılı 2011
Eser Adı
[dc.title]
Prostate specific antigen levels after acute myocardial infarction
Yazar
[dc.contributor.author]
Acikgoz, Serefden
Yazar
[dc.contributor.author]
Can, Murat
Yazar
[dc.contributor.author]
Dogan, Salt Mesut
Yazar
[dc.contributor.author]
Mungan, Gorkem
Yazar
[dc.contributor.author]
Aydin, Mustafa
Yazar
[dc.contributor.author]
Kelek, Serdar
Yazar
[dc.contributor.author]
Sumbuloglu, Vildan
Yayın Yılı
[dc.date.issued]
2011
Yayıncı
[dc.publisher]
ACTA BIOCHIMICA POLONICA
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Prostate Specific Antigen (PSA), a member of kallikrein family, is a specific serine protease of prostatic tissue. In some case reports, changes in PSA levels after acute myocardial infarction (AMI) have been reported. In this study we evaluated variations in PSA levels post-AMI. Twenty-six male patients who had PSA levels within reference limits were included in the study. The diagnosis of AMI was confirmed by clinical findings, ECG (electrocardiogram) and cardiac marker studies. Serum total PSA (tPSA) and free PSA (fPSA) levels were measured at days 0 (day of admission), 1, 2 and 3 after AMI. PSA/albumin ratio was also calculated in order to evaluate the effect of dilution. A statistical analysis of the results of all patients revealed significant decrease in tPSA levels and tPSA/Albumin ratio at day 2 when compared to days 0 and 3, which showed a similar pattern. Changes of fPSA and fPSA/Albumin ratio according to days were not found significant. In only four patients we found increased levels of tPSA and increased fPSA levels in three of them. These patients displayed severe problems such as renal failure, cardiac failure, ventricular aneurysm and cerebral ischemia due to cardiac arrest. The lower tPSA levels on day 2 suggest that tPSA can be eliminated rapidly from the circulation on days 1 and 2, probably through the formation of complexes of tPSA with acute phase proteins.
Açıklama
[dc.description]
WOS: 000298781000014
Açıklama
[dc.description]
PubMed: 22187678
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
acute myocardial infarction
Konu Başlıkları
[dc.subject]
total prostate specific antigen
Konu Başlıkları
[dc.subject]
free prostate specific antigen
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0001-527X
ISSN
[dc.identifier.issn]
1734-154X
İlk Sayfa Sayısı
[dc.identifier.startpage]
541
Son Sayfa Sayısı
[dc.identifier.endpage]
545
Dergi Adı
[dc.relation.journal]
ACTA BIOCHIMICA POLONICA
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
58
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3179
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
30
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
24 Şubat 2024 18:34
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levels patients cardiac failure increased significant according results revealed decrease tPSA/Albumin fPSA/Albumin Changes pattern similar showed compared Prostate displayed suggest proteins complexes formation through probably circulation rapidly eliminated arrest ischemia cerebral aneurysm ventricular problems severe
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