Cardiac autonomic activity in obstructive sleep apnea - Time-dependent and spectral analysis of heart rate variability using 24-hour holter electrocardiograms

To analyze the function of cardiac autonomic regulation in patients with obstructive sleep apnea, syndrome (OSAS), we enrolled 36 patients with OSAS and divided them according to the apnea hypopnea index (AHI) into 2 groups: Group I (n = 19) had mild OSAS (AHI <20) and Group II (n = 17) had severe OSAS (AHI greater than or equal to20). The findings were, compared with those of 24 healthy control subjects who were matched for age, sex, blood pressure, and body mass index. All participants underwent 24-hour Holter monitoring, with continuous time-dependent and spectral analysis of heart rate variability. In addition, we performed arrhythmia analysis. Frequent or repetitive ventricular arrhythmias (greater than or equal to30 premature ventricular beats/hour) were detected in 15 (42%) patients with OSAS and in 6 (25%) members of the control group. In both mild and severe OSAS, SDNN was significantly lower than in controls, and SDANN findings were similar. In mild OSAS, RMSSD values were not significantly lower than in controls, but in severe OSAS they were. The ULF VLF LF and LF/HF values of both groups of OSAS patients were significantly higher than those of controls, but their HF values were lower The mean LF/HF ratio during the same period was significantly higher in Group II than in Group I and the control group. Our results suggest that cardiac autonomic activity may be altered in patients with OSAS throughout a 24-hour period, that this alteration occurs even in the absence of hypertension, heart failure, or other disease states, and that it is linked to the severity of OSAS.

Dergi Adı TEXAS HEART INSTITUTE JOURNAL
Dergi Cilt Bilgisi 31
Dergi Sayısı 2
Sayfalar 132 - 136
Yayın Yılı 2004
Eser Adı
[dc.title]
Cardiac autonomic activity in obstructive sleep apnea - Time-dependent and spectral analysis of heart rate variability using 24-hour holter electrocardiograms
Yazar
[dc.contributor.author]
Aydin, M
Yazar
[dc.contributor.author]
Altin, R
Yazar
[dc.contributor.author]
Ozeren, A
Yazar
[dc.contributor.author]
Kart, L
Yazar
[dc.contributor.author]
Bilge, M
Yazar
[dc.contributor.author]
Unalacak, M
Yayın Yılı
[dc.date.issued]
2004
Yayıncı
[dc.publisher]
TEXAS HEART INST
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
To analyze the function of cardiac autonomic regulation in patients with obstructive sleep apnea, syndrome (OSAS), we enrolled 36 patients with OSAS and divided them according to the apnea hypopnea index (AHI) into 2 groups: Group I (n = 19) had mild OSAS (AHI <20) and Group II (n = 17) had severe OSAS (AHI greater than or equal to20). The findings were, compared with those of 24 healthy control subjects who were matched for age, sex, blood pressure, and body mass index. All participants underwent 24-hour Holter monitoring, with continuous time-dependent and spectral analysis of heart rate variability. In addition, we performed arrhythmia analysis. Frequent or repetitive ventricular arrhythmias (greater than or equal to30 premature ventricular beats/hour) were detected in 15 (42%) patients with OSAS and in 6 (25%) members of the control group. In both mild and severe OSAS, SDNN was significantly lower than in controls, and SDANN findings were similar. In mild OSAS, RMSSD values were not significantly lower than in controls, but in severe OSAS they were. The ULF VLF LF and LF/HF values of both groups of OSAS patients were significantly higher than those of controls, but their HF values were lower The mean LF/HF ratio during the same period was significantly higher in Group II than in Group I and the control group. Our results suggest that cardiac autonomic activity may be altered in patients with OSAS throughout a 24-hour period, that this alteration occurs even in the absence of hypertension, heart failure, or other disease states, and that it is linked to the severity of OSAS.
Açıklama
[dc.description]
WOS: 000221963700006
Açıklama
[dc.description]
PubMed: 15212122
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
autonomic nervous system
Konu Başlıkları
[dc.subject]
electrocardiography
Konu Başlıkları
[dc.subject]
heart rate
Konu Başlıkları
[dc.subject]
polysomnography
Konu Başlıkları
[dc.subject]
sleep apnea syndromes/complications
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1526-6702
İlk Sayfa Sayısı
[dc.identifier.startpage]
132
Son Sayfa Sayısı
[dc.identifier.endpage]
136
Dergi Adı
[dc.relation.journal]
TEXAS HEART INSTITUTE JOURNAL
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
31
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2193
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
16
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
11 Nisan 2024 02:02
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patients significantly severe controls values control 24-hour findings period higher groups cardiac autonomic ventricular analysis members similar alteration severity linked states disease failure hypertension absence occurs throughout altered activity suggest results during time-dependent subjects healthy
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