Serum levels of tumor necrosis factor-alpha, interleukin-6 and interleukin-8 are not increased in dyspeptic patients with Helicobacter pylori-associated gastritis

Introduction: Helicobacter pylori ( H. pylori) is a non-invasive microorganism causing intense gastric mucosal inflammatory and immune reaction. H. pylori-induced gastric mucosal cytokine overproduction has been clearly documented previously. The stomach has a large surface area and continuous spill-over of locally produced cytokines into the blood stream is a possibility. There are few and conflicting data on circulatory proinflammatory cytokine levels in patients with H. pylori infection. Materials and methods: Forty-two dyspeptic patients were enrolled into the study. The presence of H. pylori infection was diagnosed with antral histopathologic examination. After overnight fasting; serum samples were obtained from each patient to determine circulating interleukin (IL)-6, IL-8 and tumor necrosis factor-alpha (TNF-alpha) levels. Results: H. pylori was shown in 30 cases using Giemsa stain in antral histopathologic evaluation. Twelve cases were negative for H. pylori staining. Both the age and sex distribution had an insignificant difference in both H pylori-positive and H. pylori-negative groups. The mean circulatory levels of IL-6, IL-8 and TNF-a in both groups were not different. The situation was same in respect to the serum levels of these cytokines and the degree of inflammation, H. pylori density and activation scores according to Sydney classification. Conclusion: We could not show elevated circulatory levels of IL-6, IL-8 and TNF-a in H. pylori-infected cases. We believe that H. pylori-related cytokine activation become concentrated on gastric mucosa and this pathogen-induced local inflammatory cascade does not cause changes in circulatory levels of these cytokines. Moreover, there is no correlation between the levels of serum cytokines and Sydney parameters.

Yazar Bayraktaroglu, T
Aras, AS
Aydemir, S
Davutoglu, C
Ustundag, Y
Atmaca, H
Borazan, A
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3311
Tek Biçim Adres 10.1080/09629350410001664789
Konu Başlıkları Helicobacter pylori infection
interleukin-6
interleukin-8
tumor necrosis factor-alpha
Sydney parameters
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı MEDIATORS OF INFLAMMATION
Dergi Cilt Bilgisi 13
Dergi Sayısı 1
Sayfalar 25 - 28
Yayın Yılı 2004
Eser Adı
[dc.title]
Serum levels of tumor necrosis factor-alpha, interleukin-6 and interleukin-8 are not increased in dyspeptic patients with Helicobacter pylori-associated gastritis
Yazar
[dc.contributor.author]
Bayraktaroglu, T
Yazar
[dc.contributor.author]
Aras, AS
Yazar
[dc.contributor.author]
Aydemir, S
Yazar
[dc.contributor.author]
Davutoglu, C
Yazar
[dc.contributor.author]
Ustundag, Y
Yazar
[dc.contributor.author]
Atmaca, H
Yazar
[dc.contributor.author]
Borazan, A
Yayın Yılı
[dc.date.issued]
2004
Yayıncı
[dc.publisher]
HINDAWI LTD
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Introduction: Helicobacter pylori ( H. pylori) is a non-invasive microorganism causing intense gastric mucosal inflammatory and immune reaction. H. pylori-induced gastric mucosal cytokine overproduction has been clearly documented previously. The stomach has a large surface area and continuous spill-over of locally produced cytokines into the blood stream is a possibility. There are few and conflicting data on circulatory proinflammatory cytokine levels in patients with H. pylori infection. Materials and methods: Forty-two dyspeptic patients were enrolled into the study. The presence of H. pylori infection was diagnosed with antral histopathologic examination. After overnight fasting; serum samples were obtained from each patient to determine circulating interleukin (IL)-6, IL-8 and tumor necrosis factor-alpha (TNF-alpha) levels. Results: H. pylori was shown in 30 cases using Giemsa stain in antral histopathologic evaluation. Twelve cases were negative for H. pylori staining. Both the age and sex distribution had an insignificant difference in both H pylori-positive and H. pylori-negative groups. The mean circulatory levels of IL-6, IL-8 and TNF-a in both groups were not different. The situation was same in respect to the serum levels of these cytokines and the degree of inflammation, H. pylori density and activation scores according to Sydney classification. Conclusion: We could not show elevated circulatory levels of IL-6, IL-8 and TNF-a in H. pylori-infected cases. We believe that H. pylori-related cytokine activation become concentrated on gastric mucosa and this pathogen-induced local inflammatory cascade does not cause changes in circulatory levels of these cytokines. Moreover, there is no correlation between the levels of serum cytokines and Sydney parameters.
Açıklama
[dc.description]
WOS: 000220516100004
Açıklama
[dc.description]
PubMed: 15203561
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Helicobacter pylori infection
Konu Başlıkları
[dc.subject]
interleukin-6
Konu Başlıkları
[dc.subject]
interleukin-8
Konu Başlıkları
[dc.subject]
tumor necrosis factor-alpha
Konu Başlıkları
[dc.subject]
Sydney parameters
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0962-9351
ISSN
[dc.identifier.issn]
1466-1861
İlk Sayfa Sayısı
[dc.identifier.startpage]
25
Son Sayfa Sayısı
[dc.identifier.endpage]
28
Dergi Adı
[dc.relation.journal]
MEDIATORS OF INFLAMMATION
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
13
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1080/09629350410001664789
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3311
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
11
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
10 Şubat 2024 02:13
Google Kontrol
Tıklayınız
levels pylori circulatory cytokines cytokine gastric Sydney antral patients infection groups histopathologic activation mucosal inflammatory changes Moreover pylori-negative pylori-positive difference insignificant correlation between distribution parameters staining negative Twelve evaluation inflammation elevated pylori-infected Conclusion classification believe
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

creativecommons
Bu site altında yer alan tüm kaynaklar Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.
Platforms