Adapalene vs. metronidazole gel for the treatment of rosacea

Background Rosacea is a common, chronic dermatosis that requires long-term therapy. Oral isotretinoin and topical and/or oral antibiotics are effective, but their usage may be limited due to side-effects. Objective The goal of the study was to compare the efficacy of topical adapalene gel (0.1%) and topical metronidazole gel (0.75%) in the treatment of patients with papulopustular rosacea. Methods This study included 55 patients with papulopustular rosacea. Diagnostic efforts were focused on clinical and histological features. Patients were randomly assigned to the adapalene (n = 30) and metronidazole (n = 25) groups. Sunlight protection factor 20 cream was used to protect all patients from sunlight. The characteristics and numbers of inflammatory papules, pustules, erythema and telangiectasia were scored at baseline and after 2, 4, 8 and 12 weeks. Side-effects were recorded at each visit. Results Fifty patients, 27 in the adapalene group and 25 in the metronidzaole group, completed the study. Significant reductions in the total number of inflammatory lesions were found in the adapalene group compared with the metronidazole group. There was no significant difference in the scores of erythema and telangiectasia in the adapalene group. However, a significant reduction in erythema was seen in the metronidazole group. Conclusions Adapalene gel is well tolerated and can be used as an alternative for topical treatment of papulopustular rosacea.

Yazar Altinyazar, HC
Koca, R
Tekin, NS
Esturk, E
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2023
Tek Biçim Adres 10.1111/j.1365-4632.2004.02130.x
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı INTERNATIONAL JOURNAL OF DERMATOLOGY
Dergi Cilt Bilgisi 44
Dergi Sayısı 3
Sayfalar 252 - 255
Yayın Yılı 2005
Eser Adı
[dc.title]
Adapalene vs. metronidazole gel for the treatment of rosacea
Yazar
[dc.contributor.author]
Altinyazar, HC
Yazar
[dc.contributor.author]
Koca, R
Yazar
[dc.contributor.author]
Tekin, NS
Yazar
[dc.contributor.author]
Esturk, E
Yayın Yılı
[dc.date.issued]
2005
Yayıncı
[dc.publisher]
BLACKWELL PUBLISHING LTD
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background Rosacea is a common, chronic dermatosis that requires long-term therapy. Oral isotretinoin and topical and/or oral antibiotics are effective, but their usage may be limited due to side-effects. Objective The goal of the study was to compare the efficacy of topical adapalene gel (0.1%) and topical metronidazole gel (0.75%) in the treatment of patients with papulopustular rosacea. Methods This study included 55 patients with papulopustular rosacea. Diagnostic efforts were focused on clinical and histological features. Patients were randomly assigned to the adapalene (n = 30) and metronidazole (n = 25) groups. Sunlight protection factor 20 cream was used to protect all patients from sunlight. The characteristics and numbers of inflammatory papules, pustules, erythema and telangiectasia were scored at baseline and after 2, 4, 8 and 12 weeks. Side-effects were recorded at each visit. Results Fifty patients, 27 in the adapalene group and 25 in the metronidzaole group, completed the study. Significant reductions in the total number of inflammatory lesions were found in the adapalene group compared with the metronidazole group. There was no significant difference in the scores of erythema and telangiectasia in the adapalene group. However, a significant reduction in erythema was seen in the metronidazole group. Conclusions Adapalene gel is well tolerated and can be used as an alternative for topical treatment of papulopustular rosacea.
Açıklama
[dc.description]
WOS: 000227499700019
Açıklama
[dc.description]
PubMed: 15807740
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0011-9059
İlk Sayfa Sayısı
[dc.identifier.startpage]
252
Son Sayfa Sayısı
[dc.identifier.endpage]
255
Dergi Adı
[dc.relation.journal]
INTERNATIONAL JOURNAL OF DERMATOLOGY
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
44
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1111/j.1365-4632.2004.02130.x
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2023
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
7
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Şubat 2024 06:11
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Tıklayınız
adapalene topical metronidazole patients papulopustular rosacea erythema treatment telangiectasia inflammatory significant recorded Side-effects lesions baseline scored alternative pustules papules numbers Results difference reductions compared Significant completed sunlight metronidzaole number scores However reduction Conclusions Adapalene tolerated
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