Evaluation of a New Hemostatic Agent Ankaferd Blood Stopper in Experimental Liver Laceration

Introduction: Hemorrhage is a leading cause of death after trauma. It is also the major cause of operating room deaths among patients who undergo liver surgery. Various techniques and materials have been attempted to manage bleeding, but a standard method has not been defined yet. We studied the hemostatic effects of Ankaferd Blood Stopper on liver injury in comparison with regenerated oxidized cellulose. Materials and Methods: Thirty Wistar albino rats underwent partial hepatic laceration by scissors. The animals were randomized to the treatment of resected surface with either Ankaferd Blood Stopper (ABS, n = 11) or regenerated oxidized cellulose (Surgicel, n = 9), or were left untreated (controls, n = 10). All the animals were resuscitated with lactated Ringer's solution at 3.3 ml/min/kg to a mean arterial pressure (MAP) of 100 mmHg. Survival time, total blood loss, resuscitation volume, and MAP were recorded for 30 min or until death. The rats that were alive at the end of 30 min were sacrificed with blood withdrawal from catheters. Results: Rats in the ABS and Surgicel groups survived significantly longer than rats in the control group (p =.0001). There were no significant differences between the ABS and the Surgicel groups in survival (p =.91). Application of ABS and Surgicel was associated with a significant reduction in blood loss compared to controls (p =.008), with no significant differences between active treatment groups (p =.74). The resuscitation volume was not different. Conclusions: ABS is as effective as Surgicel in achieving hemostasis following partial liver excision in an experimental rat model.

Yazar Karakaya, Kemal
Ucan, Hamdi B.
Tascilar, Oge
Emre, Ali U.
Cakmak, Guldeniz K.
Irkorucu, Oktay
Ankarali, Handan
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2575
Tek Biçim Adres 10.1080/08941930902866246
Konu Başlıkları Ankaferd Blood Stopper
hemorrhage
liver
hemostasis
trauma
rat
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı JOURNAL OF INVESTIGATIVE SURGERY
Dergi Cilt Bilgisi 22
Dergi Sayısı 3
Sayfalar 201 - 206
Yayın Yılı 2009
Eser Adı
[dc.title]
Evaluation of a New Hemostatic Agent Ankaferd Blood Stopper in Experimental Liver Laceration
Yazar
[dc.contributor.author]
Karakaya, Kemal
Yazar
[dc.contributor.author]
Ucan, Hamdi B.
Yazar
[dc.contributor.author]
Tascilar, Oge
Yazar
[dc.contributor.author]
Emre, Ali U.
Yazar
[dc.contributor.author]
Cakmak, Guldeniz K.
Yazar
[dc.contributor.author]
Irkorucu, Oktay
Yazar
[dc.contributor.author]
Ankarali, Handan
Yayın Yılı
[dc.date.issued]
2009
Yayıncı
[dc.publisher]
TAYLOR & FRANCIS INC
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Introduction: Hemorrhage is a leading cause of death after trauma. It is also the major cause of operating room deaths among patients who undergo liver surgery. Various techniques and materials have been attempted to manage bleeding, but a standard method has not been defined yet. We studied the hemostatic effects of Ankaferd Blood Stopper on liver injury in comparison with regenerated oxidized cellulose. Materials and Methods: Thirty Wistar albino rats underwent partial hepatic laceration by scissors. The animals were randomized to the treatment of resected surface with either Ankaferd Blood Stopper (ABS, n = 11) or regenerated oxidized cellulose (Surgicel, n = 9), or were left untreated (controls, n = 10). All the animals were resuscitated with lactated Ringer's solution at 3.3 ml/min/kg to a mean arterial pressure (MAP) of 100 mmHg. Survival time, total blood loss, resuscitation volume, and MAP were recorded for 30 min or until death. The rats that were alive at the end of 30 min were sacrificed with blood withdrawal from catheters. Results: Rats in the ABS and Surgicel groups survived significantly longer than rats in the control group (p =.0001). There were no significant differences between the ABS and the Surgicel groups in survival (p =.91). Application of ABS and Surgicel was associated with a significant reduction in blood loss compared to controls (p =.008), with no significant differences between active treatment groups (p =.74). The resuscitation volume was not different. Conclusions: ABS is as effective as Surgicel in achieving hemostasis following partial liver excision in an experimental rat model.
Açıklama
[dc.description]
WOS: 000266280200008
Açıklama
[dc.description]
PubMed: 19466658
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Ankaferd Blood Stopper
Konu Başlıkları
[dc.subject]
hemorrhage
Konu Başlıkları
[dc.subject]
liver
Konu Başlıkları
[dc.subject]
hemostasis
Konu Başlıkları
[dc.subject]
trauma
Konu Başlıkları
[dc.subject]
rat
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0894-1939
İlk Sayfa Sayısı
[dc.identifier.startpage]
201
Son Sayfa Sayısı
[dc.identifier.endpage]
206
Dergi Adı
[dc.relation.journal]
JOURNAL OF INVESTIGATIVE SURGERY
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
22
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1080/08941930902866246
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2575
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
320
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
11 Haziran 2024 07:42
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Tıklayınız
Surgicel significant groups treatment Ankaferd Stopper differences between regenerated partial animals cellulose volume resuscitation oxidized withdrawal sacrificed Introduction recorded Survival catheters controls experimental excision following hemostasis achieving effective Conclusions different active compared Results reduction associated
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