Neurobiology of Tourette Syndrome

Tourette Syndrome (TS) is a neurodevelopmental disorder characterized by chronic motor and vocal tics. Although it is a common disorder in childhood, the etiology of Tourette Syndrome has not been fully elucidated yet. Studies, -conducted so far-have revealed differences in neurobiological structures of individuals who suffer from Tourette Syndrome. The objective of this review is to assess etiological and pathophysiological studies in the Tourette Syndrome literature. An electronical search was conducted in PubMed database using the keywords tic disorders, Tourette Syndrome, neurobiology, genetics, neuroimaging and animal models. Research and review studies published between 1985 and 2015, with a selection preference towards recent publications, were reviewed. According to the studies, genetic predisposition hypothesis is considered as a priority. However, a precise genetic disorder associated with Tourette Syndrome has not been found. The evidence from postmortem and neuroimaging studies in heterogenous patient groups and animal studies supports the pathological involvement of cortico-striato-thalamo-cortical (CSTC) circuits in Tourette Syndrome. Consequently, the most emphasized hypothesis in the pathophysiology is the dopaminergic dysfunction in these circuits. Furthermore, these findings of the animal, postmortem and neuroimaging studies have confirmed the neurodevelopmental hypothesis of Tourette Syndrome. In conclusion, more studies are needed to understand the etiology of the disorder. The data obtained from neurobiological studies of the disorder will not only shed light on the way of Tourette Syndrome, but also guide studies on its treatment options.

Dergi Adı TURK PSIKIYATRI DERGISI
Dergi Cilt Bilgisi 27
Dergi Sayısı 4
Sayfalar 275 - 285
Yayın Yılı 2016
Eser Adı
[dc.title]
Neurobiology of Tourette Syndrome
Yazar
[dc.contributor.author]
Unal, Dilek
Yazar
[dc.contributor.author]
Akdemir, Devrim
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
TURKIYE SINIR VE RUH SAGLIGI DERNEGI
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Tourette Syndrome (TS) is a neurodevelopmental disorder characterized by chronic motor and vocal tics. Although it is a common disorder in childhood, the etiology of Tourette Syndrome has not been fully elucidated yet. Studies, -conducted so far-have revealed differences in neurobiological structures of individuals who suffer from Tourette Syndrome. The objective of this review is to assess etiological and pathophysiological studies in the Tourette Syndrome literature. An electronical search was conducted in PubMed database using the keywords tic disorders, Tourette Syndrome, neurobiology, genetics, neuroimaging and animal models. Research and review studies published between 1985 and 2015, with a selection preference towards recent publications, were reviewed. According to the studies, genetic predisposition hypothesis is considered as a priority. However, a precise genetic disorder associated with Tourette Syndrome has not been found. The evidence from postmortem and neuroimaging studies in heterogenous patient groups and animal studies supports the pathological involvement of cortico-striato-thalamo-cortical (CSTC) circuits in Tourette Syndrome. Consequently, the most emphasized hypothesis in the pathophysiology is the dopaminergic dysfunction in these circuits. Furthermore, these findings of the animal, postmortem and neuroimaging studies have confirmed the neurodevelopmental hypothesis of Tourette Syndrome. In conclusion, more studies are needed to understand the etiology of the disorder. The data obtained from neurobiological studies of the disorder will not only shed light on the way of Tourette Syndrome, but also guide studies on its treatment options.
Açıklama
[dc.description]
WOS: 000390323600007
Açıklama
[dc.description]
PubMed: 28046197
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
tur
Konu Başlıkları
[dc.subject]
Tic disorders
Konu Başlıkları
[dc.subject]
Tourette Syndrome
Konu Başlıkları
[dc.subject]
neurobiology
Konu Başlıkları
[dc.subject]
genetics
Konu Başlıkları
[dc.subject]
neuroimaging
Konu Başlıkları
[dc.subject]
animal models
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1300-2163
İlk Sayfa Sayısı
[dc.identifier.startpage]
275
Son Sayfa Sayısı
[dc.identifier.endpage]
285
Dergi Adı
[dc.relation.journal]
TURK PSIKIYATRI DERGISI
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
27
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.5080/u13640
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2990
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
23
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 07:15
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Tıklayınız
studies Tourette Syndrome disorder neuroimaging animal hypothesis neurobiological neurodevelopmental postmortem review genetic circuits etiology involvement (CSTC) Consequently predisposition cortico-striato-thalamo-cortical precise patient pathological supports groups However heterogenous evidence considered associated priority Furthermore emphasized obtained options treatment
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